GBRG2_HUMAN - dbPTM
GBRG2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GBRG2_HUMAN
UniProt AC P18507
Protein Name Gamma-aminobutyric acid receptor subunit gamma-2
Gene Name GABRG2
Organism Homo sapiens (Human).
Sequence Length 467
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane
Multi-pass membrane protein . Cell membrane
Multi-pass membrane protein . Cell projection, dendrite . Cytoplasmic vesicle membrane .
Protein Description Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel..
Protein Sequence MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
42PhosphorylationPGFTSQKSDDDYEDY
CCCCCCCCCCCHHHH		38.34-
46PhosphorylationSQKSDDDYEDYASNK
CCCCCCCHHHHHHCC		20.07-
49PhosphorylationSDDDYEDYASNKTWV
CCCCHHHHHHCCEEE		10.45-
52N-linked_GlycosylationDYEDYASNKTWVLTP
CHHHHHHCCEEEECC		37.29UniProtKB CARBOHYD
83UbiquitinationGYDNKLRPDIGVKPT
CCCCCCCCCCCCCCC		48.2730230243
128UbiquitinationWYDRRLKFNSTIKVL
HHHHHHHCCCEEEEE		11.7630230243
129N-linked_GlycosylationYDRRLKFNSTIKVLR
HHHHHHCCCEEEEEE		36.33UniProtKB CARBOHYD
133UbiquitinationLKFNSTIKVLRLNSN
HHCCCEEEEEECCCC		34.9929967540
164PhosphorylationKADAHWITTPNRMLR
CCCCEEECCCCCEEE		30.8925072903
165PhosphorylationADAHWITTPNRMLRI
CCCEEECCCCCEEEE		14.9425072903
181PhosphorylationNDGRVLYTLRLTIDA
CCCEEEEEEEEEECC		10.9724719451
194UbiquitinationDAECQLQLHNFPMDE
CCEEEEEECCCCCCC		4.9230230243
201UbiquitinationLHNFPMDEHSCPLEF
ECCCCCCCCCCCCCC		31.3030230243
220UbiquitinationYPREEIVYQWKRSSV
CCHHHHEEEEECCCC		17.8330230243
223UbiquitinationEEIVYQWKRSSVEVG
HHHEEEEECCCCCCC		27.2030230243
225PhosphorylationIVYQWKRSSVEVGDT
HEEEEECCCCCCCCC		34.7030177828
226PhosphorylationVYQWKRSSVEVGDTR
EEEEECCCCCCCCCC		26.7430177828
232PhosphorylationSSVEVGDTRSWRLYQ
CCCCCCCCCCEEEEE		22.2230177828
234PhosphorylationVEVGDTRSWRLYQFS
CCCCCCCCEEEEEEE		20.7421060948
238PhosphorylationDTRSWRLYQFSFVGL
CCCCEEEEEEEEECC		10.0321060948
247N-linked_GlycosylationFSFVGLRNTTEVVKT
EEEECCCCCEEEEEE		57.29UniProtKB CARBOHYD
253PhosphorylationRNTTEVVKTTSGDYV
CCCEEEEEECCCCEE		51.79-
253 (in isoform 3)Phosphorylation-51.79-
263UbiquitinationSGDYVVMSVYFDLSR
CCCEEEEEEEEEHHH		11.3130230243
305PhosphorylationKDAVPARTSLGITTV
CCCCCCCCCCCCEEE		30.3422210691
306PhosphorylationDAVPARTSLGITTVL
CCCCCCCCCCCEEEE		21.0322210691
314PhosphorylationLGITTVLTMTTLSTI
CCCEEEECHHHHHHH		14.2422210691
316PhosphorylationITTVLTMTTLSTIAR
CEEEECHHHHHHHHH		21.2522210691
320PhosphorylationLTMTTLSTIARKSLP
ECHHHHHHHHHHCCC		23.0522210691
366PhosphorylationFVSNRKPSKDKDKKK
HHCCCCCCCCCCCCC		57.4317875639
444PhosphorylationRIAKMDSYARIFFPT
EEEECCCHHHHHHHH		8.81-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
366SPhosphorylationKinasePRKCEQ02156
GPS
366SPhosphorylationKinasePKC-FAMILY-GPS
366SPhosphorylationKinasePKC_GROUP-PhosphoELM
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GBRG2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GBRG2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GBRAP_HUMANGABARAPphysical
11948245
DRD5_HUMANDRD5physical
10659839
GBRAP_HUMANGABARAPphysical
9892355
GBRG1_HUMANGABRG1physical
28514442
TBB1_HUMANTUBB1physical
28514442
DJC18_HUMANDNAJC18physical
28514442
BSCL2_HUMANBSCL2physical
28514442
B4GT5_HUMANB4GALT5physical
28514442
CALX_HUMANCANXphysical
28514442
GPAA1_HUMANGPAA1physical
28514442
LCLT1_HUMANLCLAT1physical
28514442
ABHEA_HUMANABHD14Aphysical
28514442
CPT1A_HUMANCPT1Aphysical
28514442
Drug and Disease Associations
Kegg Disease
H00783 Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GE
H00808 Idiopathic generalized epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile abse
OMIM Disease
607681Epilepsy, childhood absence 2 (ECA2)
611277Febrile seizures, familial, 8 (FEB8)
611277Generalized epilepsy with febrile seizures plus 3 (GEFS+3)
Kegg Drug
D00058 Gamma-Aminobutyric acid (JAN); Gammalon (TN)
D00225 Alprazolam (JP16/USP/INN); Xanax (TN)
D00267 Chlordiazepoxide (JP16/USP/INN); Libritabs (TN)
D00280 Clonazepam (JP16/USP/INN); Klonopin (TN)
D00293 Diazepam (JP16/USP/INN); Diastat (TN); Valium (TN)
D00311 Estazolam (JP16/USAN/INN); ProSom (TN)
D00329 Flurazepam (JAN/INN); Insumin (TN)
D00365 Lorazepam (JP16/USP/INN); Ativan (TN)
D00370 Temazepam (USP/INN); Restoril (TN)
D00376 Meprobamate (JAN/USP/INN); Equanil (TN); Miltown (TN)
D00387 Triazolam (JAN/USP/INN); Halcion (TN)
D00430 Secobarbital (USP/INN); Seconal (TN)
D00457 Quazepam (JAN/USP/INN); Doral (TN)
D00470 Prazepam (JP16/USAN/INN); Centrax (TN)
D00499 Pentobarbital (USP/INN); Nembutal (TN)
D00500 Pentobarbital sodium (JAN/USP); Nembutal sodium (TN)
D00506 Phenobarbital (JP16/USP/INN); Luminal (TN)
D00531 Nitrazepam (JP16/USAN/INN); Benzalin (TN); Nitrazepam (TN)
D00532 Glutethimide (JAN/INN); Doriden (TN)
D00549 Propofol (JAN/USAN/INN); Diprivan (TN)
D00550 Midazolam (JAN/USP/INN); Dormicum (TN); Buccolam (TN)
D00555 Amobarbital (JP16/INN); Isomytal (TN)
D00557 Methaqualone (JAN/USAN/INN)
D00693 Chlordiazepoxide hydrochloride (JAN/USP); Librium (TN)
D00694 Clorazepate dipotassium (JP16/USP); Tranxene (TN)
D00695 Flurazepam hydrochloride (USP); Flurazepam dihydrochloride; Dalmane (TN)
D00696 Midazolam hydrochloride (USAN); Versed (TN)
D00697 Flumazenil (JAN/USP/INN); Romazicon (TN)
D00700 Mephobarbital (JAN/USP); Methylphenobarbital (INN); Mebaral (TN)
D00701 Phenobarbital sodium (JAN/USP/INN); Luminal sodium (TN)
D00706 Zolpidem tartrate (JP16/USAN); Ambien (TN); Intermezzo (TN)
D00713 Thiamylal sodium (JP16); Surital (TN)
D00714 Thiopental sodium (JP16/USP/INN); Pentothal (TN)
D01071 Hexobarbital (JAN/INN)
D01230 Flunitrazepam (JP16/USAN/INN); Rohypnol (TN)
D01245 Bromazepam (JP16/USAN/INN); Lectopam (TN)
D01253 Clobazam (JAN/USAN/INN); Mystan (TN); Onfi (TN)
D01254 Tofisopam (JP16/INN); Emandaxin (TN)
D01268 Cloxazolam (JP16/INN); Sepazon (TN)
D01278 Oxazolam (JP16/INN); Serenal (TN)
D01279 Flutoprazepam (JP16/INN); Restas (TN)
D01286 Flutazolam (JAN/INN); Coreminal (TN)
D01292 Medazepam (JP16/INN); Pamnace (TN)
D01293 Ethyl loflazepate (JAN/INN); Meilax (TN)
D01310 Secobarbital sodium (JAN/USP); Seconal sodium (TN)
D01316 Mexazolam (JAN/INN); Melex (TN)
D01328 Clotiazepam (JP16/INN); Rize (TN)
D01354 Fludiazepam (JP16/INN); Erispan (TN)
D01372 Zopiclone (JAN/INN); Amoban (TN); Zopiclone (TN)
D01408 Flurazepam hydrochloride (JP16); Flurazepam monohydrochloride; Dalmate (TN)
D01514 Etizolam (JP16/INN); Sedekopan (TN)
D01564 Rilmazafone hydrochloride hydrate (JAN); Rilmazafone hydrochloride dihydrate; Rilmazafone hydrochlor
D01593 Nimetazepam (JAN/INN); Erimin (TN)
D01657 Lormetazepam (JAN/USAN/INN); Loramet (TN)
D01740 Barbital (JP16/INN); Barbital (TN)
D01744 Brotizolam (JP16/USAN/INN); Lendormin (TN)
D01758 Haloxazolam (JP16/INN); Somelin (TN)
D02252 Amobarbital sodium (JAN/USP); Amytal sodium (TN)
D02253 Pentobarbital calcium (JP16); Ravona (TN)
D02283 Iomazenil (123I) (JAN/INN); Benzodine (TN)
D02594 Abecarnil (INN)
D02616 Pagoclone (USAN/INN); Bextra (TN)
D02617 Ocinaplon (USAN/INN)
D02624 Eszopiclone (JAN/USAN/INN); Estorra (TN); Lunesta (TN)
D02833 Alpidem (USAN/INN)
D03155 Bretazenil (USAN/INN)
D03562 Clorazepate monopotassium (USAN)
D03737 Dextofisopam (USAN/INN)
D04257 Fospropofol disodium (USAN); Aquavan (TN); Lusedra (TN)
D04282 Gaboxadol (USAN/INN)
D04300 Ganaxolone (USAN/INN)
D04721 Levotofisopam (USAN/INN)
D04882 Medazepam hydrochloride (USAN); Nobrium (TN)
D05028 Midazolam maleate (USAN)
D06106 Thiamylal
D07326 Loprazolam (INN); Dormonoct (TN)
D07409 Pentetrazol (INN); Pentylenetetrazol; Coryvet [veterinary] (TN)
D07784 Delorazepam (INN); Dadumir (TN)
D08145 Loprazolam mesilate; Loprazolam mesylate; Loprazolam methanesulfonate; Havlane (TN)
D08283 Nordazepam (INN); Calmday (TN)
D08356 Phenobarbital diethylamine; Gratusminal (TN)
D08481 Rilmazafone (INN)
D08507 Sarmazenil (INN); Sarmazol [veterinary] (TN)
D08690 Zolpidem (INN); Sanval (TN)
D08840 Adipiplon (USAN)
D10194 Remimazolam besilate (JAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GBRG2_HUMAN

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Related Literatures of Post-Translational Modification

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