| UniProt ID | GBRG1_HUMAN | |
|---|---|---|
| UniProt AC | Q8N1C3 | |
| Protein Name | Gamma-aminobutyric acid receptor subunit gamma-1 | |
| Gene Name | GABRG1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 465 | |
| Subcellular Localization |
Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein. Cell membrane Multi-pass membrane protein. |
|
| Protein Description | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.. | |
| Protein Sequence | MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNQKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 50 | N-linked_Glycosylation | DDEDLTVNKTWVLAP CCCCCEECEEEEECC | 30.70 | UniProtKB CARBOHYD | |
| 127 | N-linked_Glycosylation | FDSRLKFNSTMKVLM HCCCCCCCCHHEEEE | 34.68 | UniProtKB CARBOHYD | |
| 179 | Phosphorylation | NDGRVLYTLRLTINA CCCEEEEEEEEEECC | 10.97 | 24719451 | |
| 218 | Phosphorylation | YPKNEIEYKWKKPSV CCCCCEEEEECCCCC | 28.01 | - | |
| 232 | Phosphorylation | VEVADPKYWRLYQFA CEECCHHHHHEEEEE | 10.93 | 23607784 | |
| 236 | Phosphorylation | DPKYWRLYQFAFVGL CHHHHHEEEEEEEEE | 7.94 | 23607784 | |
| 245 | N-linked_Glycosylation | FAFVGLRNSTEITHT EEEEEECCCCEEEEE | 59.32 | UniProtKB CARBOHYD | |
| 303 | Phosphorylation | KDAVPARTSLGITTV CCCCCCCCCCCCEEE | 30.34 | 22210691 | |
| 304 | Phosphorylation | DAVPARTSLGITTVL CCCCCCCCCCCEEEE | 21.03 | 22210691 | |
| 312 | Phosphorylation | LGITTVLTMTTLSTI CCCEEEECHHHHHHH | 14.24 | 22210691 | |
| 314 | Phosphorylation | ITTVLTMTTLSTIAR CEEEECHHHHHHHHH | 21.25 | 22210691 | |
| 318 | Phosphorylation | LTMTTLSTIARKSLP ECHHHHHHHHHHCCC | 23.05 | 22210691 | |
| 441 | Phosphorylation | IRIAKIDSYSRIFFP EEEEEECCCCCCHHH | 28.60 | 23312004 | |
| 442 | Phosphorylation | RIAKIDSYSRIFFPT EEEEECCCCCCHHHH | 9.75 | 23312004 | |
| 443 | Phosphorylation | IAKIDSYSRIFFPTA EEEECCCCCCHHHHH | 23.89 | 23312004 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GBRG1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GBRG1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GBRG1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GBRG1_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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