DRD5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DRD5_HUMAN
• UniProt AC: P21918
• Protein Name: D(1B) dopamine receptor
• Gene Name: DRD5
• Organism: Homo sapiens (Human).
• Sequence Length: 477
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase..
• Protein Sequence: MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	N-linked_Glycosylation	-MLPPGSNGTAYPGQ -CCCCCCCCCCCCCH	58.72	10531415
222	N-linked_Glycosylation	ENCDSSLNRTYAISS HHCCCCCCHHHHHCH	35.87	UniProtKB CARBOHYD
249	Phosphorylation	IVTYTRIYRIAQVQI HHHHHHHHHHHHHHH	7.83	-
375	S-palmitoylation	VFAQLLGCSHFCSRT HHHHHHCCCHHHCCC	2.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DRD5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DRD5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DRD5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNA13_HUMAN	GNA13	physical	12623966
GNA12_HUMAN	GNA12	physical	12623966

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 606798: Benign essential blepharospasm (BEB)
• Kegg Drug
• D00059: Levodopa (JP16/USP/INN); Dopar (TN)
• D00633: Dopamine hydrochloride (JP16/USP); Actopamin (TN); Intropin (TN)
• D02676: Oxiperomide (USAN/INN)
• D03891: Dopexamine (USAN/INN)
• D03937: Ecopipam hydrochloride (USAN)
• D07870: Dopamine (INN); Medopa (TN)
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"N-linked glycosylation is required for plasma membrane localizationof D5, but not D1, dopamine receptors in transfected mammaliancells.";
Karpa K.D., Lidow M.S., Pickering M.T., Levenson R., Bergson C.;
Mol. Pharmacol. 56:1071-1078(1999).
Cited for: GLYCOSYLATION AT ASN-7, AND MUTAGENESIS OF ASN-7.
PubMed: 10531415