FRAT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FRAT1_HUMAN
• UniProt AC: Q92837
• Protein Name: Proto-oncogene FRAT1
• Gene Name: FRAT1
• Organism: Homo sapiens (Human).
• Sequence Length: 279
• Subcellular Localization: Cytoplasm.
• Protein Description: Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis..
• Protein Sequence: MPCRREEEEEAGEEAEGEEEEEDSFLLLQQSVALGSSGEVDRLVAQIGETLQLDAAQHSPASPCGPPGAPLRAPGPLAAAVPADKARSPAVPLLLPPALAETVGPAPPGVLRCALGDRGRVRGRAAPYCVAELATGPSALSPLPPQADLDGPPGAGKQGIPQPLSGPCRRGWLRGAAASRRLQQRRGSQPETRTGDDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGPLSAPVHEPPSPRSPRAACSDPGASGRAQLRTGDGVLVPGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88	Phosphorylation	VPADKARSPAVPLLL CCCCHHCCCCCCCCC	23.28	28450419
128	Phosphorylation	VRGRAAPYCVAELAT CCCCCCCCEEEHHHC	8.53	22210691
135	Phosphorylation	YCVAELATGPSALSP CEEEHHHCCCCCCCC	63.35	22210691
138	Phosphorylation	AELATGPSALSPLPP EHHHCCCCCCCCCCC	43.09	22210691
179	Phosphorylation	WLRGAAASRRLQQRR HHHHHHHHHHHHHHC	17.13	30206219
188	Phosphorylation	RLQQRRGSQPETRTG HHHHHCCCCCCCCCC	40.53	22817900
214	Ubiquitination	VLSGNLIKEAVRRLH HHCCHHHHHHHHHHH	42.67	-
241	Phosphorylation	RPLLGPLSAPVHEPP CCCCCCCCCCCCCCC	33.39	27080861
249	Phosphorylation	APVHEPPSPRSPRAA CCCCCCCCCCCCCHH	43.60	24719451
252	Phosphorylation	HEPPSPRSPRAACSD CCCCCCCCCCHHCCC	23.32	-
258	Phosphorylation	RSPRAACSDPGASGR CCCCHHCCCCCCCCC	41.96	28348404
279	Phosphorylation	DGVLVPGS------- CCCCCCCC-------	30.86	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
188	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
188	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
188	S	Phosphorylation	Kinase	PRKCA	P17252	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FRAT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FRAT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DVL1_HUMAN	DVL1	physical	10428961
GASP2_HUMAN	GPRASP2	physical	21988832
LAMC3_HUMAN	LAMC3	physical	21988832
K1C18_HUMAN	KRT18	physical	21988832
GRN_HUMAN	GRN	physical	21988832
PLS1_HUMAN	PLSCR1	physical	21988832
PSA3_HUMAN	PSMA3	physical	21988832
LTBP4_HUMAN	LTBP4	physical	21988832
KCNK5_HUMAN	KCNK5	physical	21988832
LMAN2_HUMAN	LMAN2	physical	21988832
TDRD7_HUMAN	TDRD7	physical	21988832
RABE2_HUMAN	RABEP2	physical	21988832
GSK3A_HUMAN	GSK3A	physical	26496610
GSK3B_HUMAN	GSK3B	physical	26496610
RASK_HUMAN	KRAS	physical	26496610
PIAS1_HUMAN	PIAS1	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88, AND MASSSPECTROMETRY.
PubMed: 19369195