| UniProt ID | KCNK5_HUMAN | |
|---|---|---|
| UniProt AC | O95279 | |
| Protein Name | Potassium channel subfamily K member 5 | |
| Gene Name | KCNK5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 499 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations.. | |
| Protein Sequence | MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLGQEGLDKILEVVSDAAGQGVAITGNQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFFGGRAKRLGQFLTKRGVSLRKAQITCTVIFIVWGVLVHLVIPPFVFMVTEGWNYIEGLYYSFITISTIGFGDFVAGVNPSANYHALYRYFVELWIYLGLAWLSLFVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKALQVKGSTASKDVNIFSFLSKKEETYNDLIKQIGKKAMKTSGGGETGPGPGLGPQGGGLPALPPSLVPLVVYSKNRVPTLEEVSQTLRSKGHVSRSPDEEAVARAPEDSSPAPEVFMNQLDRISEECEPWDAQDYHPLIFQDASITFVNTEAGLSDEETSKSSLEDNLAGEESPQQGAEAKAPLNMGEFPSSSESTFTSTESELSVPYEQLMNEYNKANSPKGT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 36 | Ubiquitination | PHWKEAKKNYYTQKL CCHHHHHHHHHHHHH | 58.17 | - | |
| 38 | Phosphorylation | WKEAKKNYYTQKLHL HHHHHHHHHHHHHHH | 19.44 | 26074081 | |
| 39 | Phosphorylation | KEAKKNYYTQKLHLL HHHHHHHHHHHHHHH | 16.46 | 26074081 | |
| 40 | Phosphorylation | EAKKNYYTQKLHLLK HHHHHHHHHHHHHHH | 14.63 | 26074081 | |
| 42 | Ubiquitination | KKNYYTQKLHLLKEF HHHHHHHHHHHHHHC | 30.03 | - | |
| 47 | Ubiquitination | TQKLHLLKEFPCLGQ HHHHHHHHHCCCCCH | 64.76 | - | |
| 77 | N-linked_Glycosylation | QGVAITGNQTFNNWN CCEEEECCCCCCCCC | 29.12 | UniProtKB CARBOHYD | |
| 131 | Phosphorylation | PLCLTWISALGKFFG HHHHHHHHHHHHHHC | 14.70 | - | |
| 150 | Ubiquitination | RLGQFLTKRGVSLRK HHHHHHHHCCCCHHH | 49.67 | - | |
| 266 | Phosphorylation | RRRRRKESFESSPHS HHHHHHHHHHCCHHH | 37.03 | 26657352 | |
| 269 | Phosphorylation | RRKESFESSPHSRKA HHHHHHHCCHHHHHC | 47.35 | 27251275 | |
| 270 | Phosphorylation | RKESFESSPHSRKAL HHHHHHCCHHHHHCH | 21.31 | 25159151 | |
| 275 | Ubiquitination | ESSPHSRKALQVKGS HCCHHHHHCHHCCCC | 57.36 | - | |
| 280 | Ubiquitination | SRKALQVKGSTASKD HHHCHHCCCCCCCCC | 33.90 | - | |
| 282 | Phosphorylation | KALQVKGSTASKDVN HCHHCCCCCCCCCCC | 18.32 | - | |
| 283 | Phosphorylation | ALQVKGSTASKDVNI CHHCCCCCCCCCCCH | 43.55 | - | |
| 285 | Phosphorylation | QVKGSTASKDVNIFS HCCCCCCCCCCCHHH | 29.49 | - | |
| 286 | Ubiquitination | VKGSTASKDVNIFSF CCCCCCCCCCCHHHH | 64.33 | - | |
| 292 | Phosphorylation | SKDVNIFSFLSKKEE CCCCCHHHHHCCCHH | 22.83 | 23312004 | |
| 296 | Ubiquitination | NIFSFLSKKEETYND CHHHHHCCCHHHHHH | 67.37 | 21906983 | |
| 297 | Ubiquitination | IFSFLSKKEETYNDL HHHHHCCCHHHHHHH | 58.36 | - | |
| 300 | Phosphorylation | FLSKKEETYNDLIKQ HHCCCHHHHHHHHHH | 28.81 | 22210691 | |
| 301 | Phosphorylation | LSKKEETYNDLIKQI HCCCHHHHHHHHHHH | 15.23 | 22210691 | |
| 306 | Ubiquitination | ETYNDLIKQIGKKAM HHHHHHHHHHHHHHH | 43.06 | - | |
| 347 | Phosphorylation | SLVPLVVYSKNRVPT HHCEEEEEECCCCCC | 13.37 | - | |
| 354 | Phosphorylation | YSKNRVPTLEEVSQT EECCCCCCHHHHHHH | 43.90 | - | |
| 371 | Phosphorylation | SKGHVSRSPDEEAVA HCCCCCCCCCHHHHH | 29.24 | 17192257 | |
| 385 | Phosphorylation | ARAPEDSSPAPEVFM HHCCCCCCCCCHHHH | 37.09 | 26657352 | |
| 410 | Phosphorylation | EPWDAQDYHPLIFQD CCCCCCCCCCEEEEC | 8.02 | - | |
| 437 | Phosphorylation | SDEETSKSSLEDNLA CCHHHCHHHHHHHCC | 39.66 | 25159151 | |
| 438 | Phosphorylation | DEETSKSSLEDNLAG CHHHCHHHHHHHCCC | 39.24 | 25159151 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KCNK5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KCNK5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KCNK5_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| D00640 | Propafenone hydrochloride (JP16/USP); Rythmol (TN) | |||||
| D00740 | Procaine hydrochloride (JP16/USP); Novocain (TN) | |||||
| D08422 | Procaine (INN); Solution of novocain (TN) | |||||
| D08435 | Propafenone (INN); Propafenon hexal (TN) | |||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-371, AND MASSSPECTROMETRY. | |
