FBL17_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBL17_ARATH
• UniProt AC: Q8W104
• Protein Name: F-box/LRR-repeat protein 17
• Gene Name: FBL17
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 593
• Subcellular Localization: Nucleus . Confined to the male germ cell nucleus of early to mid bicellular pollen.
• Protein Description: Essential protein for male fertility. Component of the SCF(ASK-cullin-F-box) E3 ubiquitin ligase complex SCF(FBL17), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Enables the switch in cell cycle control leading to male germ cell lineage formation from microspores after meiosis. Targets CDKA-1 inhibitors the degradation specifically in male germ cells (e.g. KRP6 and KRP7) and thus enables CDKA-1 activation and germ cell S-phase progression. Promotes twin sperm cell production and double fertilization..
• Protein Sequence: MQPQPHISPNTATAAISAALESQRSRKNRGSYNCGRCGQPKKGHVCLLTAPPDIPTTPIASEPVSCISAAASSSRSTVLSLTAAPSSRQTFTHLRRALSFDDVDARNSLDESDLDAASMDLDLQLDTDIVQPGRFHAVGLWEVLKRLPPSSLLMAARVCKGWRETSRKMWKAAEELRIRVPERAQIGYIGSLLQKCPRLIRLSLKIESDFDATTLACIAFSCPNLEVLEITTSGAAVNRISGDELSRFVANKRGLTSLKMEGCSNLGGFSLSSSSLSTLWLSDLHSLSKMIFNCPNLTEISLEFSRQEDDSTDLVTMVDGLGRTCTRLQNIHIASLKLSHTVVLSLTAVNFRYLRMLSLVLGINITDASVAAISSGYKNLELLDLSGSSITDTGLGMICDVLPDTLSKLLVALCPNITSSGIQFATAQLPLLELMDCGMTVSDPNSDNPTFVENPSPHKTPGYNQKMFIKHKRLKKLSLWGCSSLDALFLNCPELMDLNLNLCSNLHPESLVLQCPKLQLVYASGCQGLLTGAIRKQVSENFSAGENHMPRKRLADASKRIQALPSLYQETREDGIYAGKRRKLEKEMCTIIH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Phosphorylation	THLRRALSFDDVDAR HHHHHHHCCCCHHHH	26.16	23776212
566	Phosphorylation	KRIQALPSLYQETRE HHHHHHHHHHHHHHH	40.33	28295753
568	Phosphorylation	IQALPSLYQETREDG HHHHHHHHHHHHHCC	14.51	28295753
571	Phosphorylation	LPSLYQETREDGIYA HHHHHHHHHHCCCCC	24.67	28295753

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBL17_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBL17_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBL17_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SKP1B_ARATH	ASK2	physical	23166809
ASK11_ARATH	SK11	physical	23166809
ASK12_ARATH	SK12	physical	23166809
SKP1A_ARATH	SKP1	physical	18948957
KRP4_ARATH	KRP4	physical	18948957
KRP6_ARATH	KRP6	physical	18948957
KRP7_ARATH	ICK5	physical	18948957

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.