EEA1_MOUSE - dbPTM
EEA1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EEA1_MOUSE
UniProt AC Q8BL66
Protein Name Early endosome antigen 1
Gene Name Eea1
Organism Mus musculus (Mouse).
Sequence Length 1411
Subcellular Localization Cytoplasm. Early endosome membrane
Peripheral membrane protein.
Protein Description Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking..
Protein Sequence MFRRILQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYQAVHDAGNDSGHGGEAGLALTRDDITLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKSDGLVTDSSAELQALEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEEKSLRAAAEQKVTHLTEDLNKQTTVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSEHAHLEATINQLRSELAKGPQEVAVYVQEIQKLKGSINELTQKNQNLTEKLQKKDLDYTHLEEKHNEESASRKTLQASLHQRDLDCQQLQARLTASESSLQRAQGELSEKAEAAQKLREELREVESTRQHLKVEVKQLQQQREEKEQHGLQLQGEVSQLHCKLLETERQLGEAHGRLKEQRQLSSEKLMEKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLEKSKQQHQEQQALQQSATAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKGKESVSLLEKEREDLYAKIQAGEGETAVLNQLQEKNHALQQQLTQLTEKLKNQSESHKQAEENLHDQVQEQKAHLRAAQDRVLSLETSVSELSSQLNESKEKVSQLDIQIKAKTELLLSAEAAKAAQRADLQNHLDTAQHALQDKQQELNKVSVQLDQLTAKFQEKQEHCIQLESHLKDHKEKHLSLEQKVEDLEGHIKKLEADALEVKASKEQALQSLQQQRQLSTDLELRNAELSRELQEQEEVVSCTKLDLQNKSEILENIKQTLTKKEEENVVLKQEFEKLSQDSKTQHKELGDRMQAAVTELTAVKAQKDALLAELSTTKEKLSKVSDSLKNSKSEFEKENQKGKAAVLDLEKACKELKHQLQVQAESALKEQEDLKKSLEKEKETSQQLKIELNSVKGEVSQAQNTLKQKEKDEQQLQGTINQLKQSAEQKKKQIEALQGEVKNAVSQKTVLENKLQQQSSQAAQELAAEKGKLSALQSNYEKCQADLKQLQSDLYGKESELLATRQDLKSVEEKLTLAQEDLISNRNQIGNQNKSIQELQAAKASLEQDSAKKEALLKEQSKALEDAQREKSVKEKELVAEKSKLAEMEEIKCRQEKEITKLNEELKSHKQESIKEITNLKDAKQLLIQQKLELQGRVDSLKAALEQEKESQQLMREQVKKEEEKRKEEFSEKEAKLHSEIKEKEAGMKKHEENEAKLTMQVTTLNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKALELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMSCGKCFSVTVRRHHCRQCGNIFCAECSTKNALTPSSKKPVRVCDACFNDLQG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationFRRILQRTPGRVGSQ
CHHHHHCCCCCCCCC		19.6823984901
15PhosphorylationRTPGRVGSQGSDLDS
CCCCCCCCCCCCCCC		28.6319060867
18PhosphorylationGRVGSQGSDLDSSAT
CCCCCCCCCCCCCCC		27.6219060867
22PhosphorylationSQGSDLDSSATPINT
CCCCCCCCCCCCCCE		29.2123984901
23PhosphorylationQGSDLDSSATPINTV
CCCCCCCCCCCCCEE		35.5123984901
25PhosphorylationSDLDSSATPINTVDV
CCCCCCCCCCCEEEC		27.0123984901
29PhosphorylationSSATPINTVDVNNES
CCCCCCCEEECCCCC		20.8523984901
36PhosphorylationTVDVNNESSSEGFIC
EEECCCCCCCCCCCC		41.0929899451
49PhosphorylationICPQCMKSLGSADEL
CCHHHHHHCCCHHHH		15.8728833060
52PhosphorylationQCMKSLGSADELFKH
HHHHHCCCHHHHHHH		37.5323984901
70PhosphorylationVHDAGNDSGHGGEAG
HHHCCCCCCCCCCHH		36.3722067460
100UbiquitinationQDLQASLKEEKWYSE
HHHHHHHHHCHHCHH		62.4222790023
115UbiquitinationELKKELEKYQGLQQQ
HHHHHHHHHHCCCHH		56.3422790023
134PhosphorylationDGLVTDSSAELQALE
CCCCCCCHHHHHHHH		28.6829899451
177PhosphorylationTEIADIKSKYDEEKS
HHHHHHHHHCCHHHH		36.4624719451
179PhosphorylationIADIKSKYDEEKSLR
HHHHHHHCCHHHHHH		35.3624719451
204PhosphorylationTEDLNKQTTVIQDLK
HHHHHHCCCHHHHHH		25.3327717184
205PhosphorylationEDLNKQTTVIQDLKT
HHHHHCCCHHHHHHH		17.0827717184
211AcetylationTTVIQDLKTELLQRP
CCHHHHHHHHHHCCC		48.5223954790
228UbiquitinationEDVAVLKKELVQVQT
CCHHHHHHHHHHHHH		52.7122790023
235PhosphorylationKELVQVQTLMDNMTL
HHHHHHHHHHHCCCH		25.78-
241PhosphorylationQTLMDNMTLERERES
HHHHHCCCHHHHHHH		31.55-
248PhosphorylationTLERERESEKLKDEC
CHHHHHHHHHHHHHH		46.37-
310MalonylationKNQNLTEKLQKKDLD
HCHHHHHHHHHCCCC		51.4826320211
396MalonylationQHLKVEVKQLQQQRE
HHHHHHHHHHHHHHH		31.6126320211
485MalonylationELQHQLEKSKQQHQE
HHHHHHHHHHHHHHH		72.1126320211
583AcetylationQLTQLTEKLKNQSES
HHHHHHHHHHHHHHH		60.5723954790
618PhosphorylationAAQDRVLSLETSVSE
HHHHHHHHHHHCHHH		22.6929899451
720PhosphorylationDHKEKHLSLEQKVED
HHHHHHCCHHHHHHH		29.5822817900
760PhosphorylationLQQQRQLSTDLELRN
HHHHHHHHHHHHHHH		16.1329514104
864MalonylationTTKEKLSKVSDSLKN
CCHHHHHHHHHHHHC		57.0826320211
870MalonylationSKVSDSLKNSKSEFE
HHHHHHHHCCHHHHH		64.2326320211
882AcetylationEFEKENQKGKAAVLD
HHHHHHHHHHHHHHH		74.1619865939
895AcetylationLDLEKACKELKHQLQ
HHHHHHHHHHHHHHH		71.5819865949
952AcetylationNTLKQKEKDEQQLQG
HHHHHHHHHHHHHHH		73.8623954790
973AcetylationQSAEQKKKQIEALQG
HHHHHHHHHHHHHHH		64.6423954790
995UbiquitinationQKTVLENKLQQQSSQ
HHHHHHHHHHHHHHH		37.9922790023
1045PhosphorylationKESELLATRQDLKSV
CHHHHHHHHHHHHHH		28.9119367708
1162MalonylationIKEITNLKDAKQLLI
HHHHCCHHHHHHHHH		58.6826320211
1165AcetylationITNLKDAKQLLIQQK
HCCHHHHHHHHHHHH		52.1723236377
1165SuccinylationITNLKDAKQLLIQQK
HCCHHHHHHHHHHHH		52.1723954790
1165MalonylationITNLKDAKQLLIQQK
HCCHHHHHHHHHHHH		52.1726320211
1181PhosphorylationELQGRVDSLKAALEQ
HHCCHHHHHHHHHHH		28.9830482847
1197UbiquitinationKESQQLMREQVKKEE
HHHHHHHHHHHHHHH		39.5327667366
1254UbiquitinationNENLGTVKKEWQSSQ
HHCCCHHHHHHHHHH		44.8322790023
1265PhosphorylationQSSQRRVSELEKQTD
HHHHHHHHHHHHHHH		34.3530387612
1312UbiquitinationEIEKLQTKALELQRK
HHHHHHHHHHHHHHH		37.7022790023
1317UbiquitinationQTKALELQRKLDNTT
HHHHHHHHHHHHCHH		30.9627667366
1354UbiquitinationRKWAEDNEVQNCMSC
HHHCCCCCCCHHHHC		58.7827667366
1359UbiquitinationDNEVQNCMSCGKCFS
CCCCCHHHHCCCCEE		4.9427667366
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EEA1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EEA1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EEA1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EEA1_HUMANEEA1physical
20360068
ABL1_HUMANABL1physical
26496610
RASK_HUMANKRASphysical
26496610
OAS3_HUMANOAS3physical
26496610
RBCC1_HUMANRB1CC1physical
26496610
IL24_HUMANIL24physical
26496610
WWP2_HUMANWWP2physical
26496610
CAMP2_HUMANCAMSAP2physical
26496610
APC4_HUMANANAPC4physical
26496610
CNDG2_HUMANNCAPG2physical
26496610
PSPC1_HUMANPSPC1physical
26496610
ASF1B_HUMANASF1Bphysical
26496610
NEUL_HUMANNLNphysical
26496610
BEGIN_HUMANBEGAINphysical
26496610
E41L5_HUMANEPB41L5physical
26496610
BCORL_HUMANBCORL1physical
26496610
FN3K_HUMANFN3Kphysical
26496610
OSBL1_HUMANOSBPL1Aphysical
26496610
IRGQ_HUMANIRGQphysical
26496610
NPHP4_HUMANNPHP4physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EEA1_MOUSE

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Related Literatures of Post-Translational Modification

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