DCP2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCP2_SCHPO
• UniProt AC: O13828
• Protein Name: mRNA decapping complex subunit 2
• Gene Name: dcp2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 741
• Subcellular Localization: Cytoplasm, P-body . Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay.
• Protein Description: Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body..
• Protein Sequence: MSFTNATFSQVLDDLSARFILNLPAEEQSSVERLCFQIEQAHWFYEDFIRAQNDQLPSLGLRVFSAKLFAHCPLLWKWSKVHEEAFDDFLRYKTRIPVRGAIMLDMSMQQCVLVKGWKASSGWGFPKGKIDKDESDVDCAIREVYEETGFDCSSRINPNEFIDMTIRGQNVRLYIIPGISLDTRFESRTRKEISKIEWHNLMDLPTFKKNKPQTMKNKFYMVIPFLAPLKKWIKKRNIANNTTKEKNISVDVDADASSQLLSLLKSSTAPSDLATPQPSTFPQPPVESHSSFDIKQKILHLLNEGNEPKSPIQLPPVSNLPLNPPIQSSNSRLSHDNNSFDPFAYLGLDPKNPSASFPRVVSQNNMLTNKPVLNNHFQQSMYSNLLKDQNSVQHLFAASDMPSPMELPSPSTVYHQVFYPPTSTSVSSYGLGKTPQPAYGSSSPYVNGHQTQQISSLPPFQSQTQFLARNSDNSGQSYNSEGDSNSKRLLSMLSQQDTTPSSSTLSKEANVQLANLFLTPNSLETKKFSDNSQGEEISDNLHGESCNNPNANSVHSAQLLQALLHPSATETKEETPKKTSDSLSLLTLLKSGLPTPANDLQNKSQNNERKASSQVKELEVKNYSKSTDLLKKTLRIPRNDEPLEAANQFDLLKVSPQQKSEVPPKRNELSQSKLKNRKKKENSETNKNHVDMSPGFVKILKRSPLADQKKEDTQESDFKGSDDHFLSYLQSVVSSNSNGLH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
310	Phosphorylation	NEGNEPKSPIQLPPV HCCCCCCCCCCCCCC	37.64	29996109
318	Phosphorylation	PIQLPPVSNLPLNPP CCCCCCCCCCCCCCC	38.12	29996109
334	Phosphorylation	QSSNSRLSHDNNSFD CCCCCCCCCCCCCCC	27.90	29996109
339	Phosphorylation	RLSHDNNSFDPFAYL CCCCCCCCCCCCHHC	36.96	25720772
362	Phosphorylation	ASFPRVVSQNNMLTN CCCCCCCCCCCCCCC	25.08	24763107
412	Phosphorylation	MELPSPSTVYHQVFY CCCCCCCCEEEEEEC	28.59	27738172
498	Phosphorylation	SMLSQQDTTPSSSTL HHHHCCCCCCCCCCC	35.95	24763107
519	Phosphorylation	QLANLFLTPNSLETK EEEEEECCCCCCCCC	17.06	29996109
591	Phosphorylation	SLLTLLKSGLPTPAN HHHHHHHCCCCCCHH	45.60	24763107
595	Phosphorylation	LLKSGLPTPANDLQN HHHCCCCCCHHHHCC	39.82	24763107
624	Phosphorylation	ELEVKNYSKSTDLLK HHHHHCCCCCHHHHH	29.53	25720772
655	Phosphorylation	QFDLLKVSPQQKSEV HCCCEECCHHHCCCC	18.53	29996109
670	Phosphorylation	PPKRNELSQSKLKNR CCCCCHHCHHHHHHH	26.65	25720772
672	Phosphorylation	KRNELSQSKLKNRKK CCCHHCHHHHHHHHH	36.26	25720772
693	Phosphorylation	NKNHVDMSPGFVKIL HHHCCCCCHHHHHHH	19.87	24763107
703	Phosphorylation	FVKILKRSPLADQKK HHHHHHCCCCCCCCC	23.76	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCP2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCP2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCP2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCP1_SCHPO	dcp1	physical	23319050
EDC3_SCHPO	edc3	physical	23319050
DHH1_SCHPO	ste13	physical	23319050
XRN1_SCHPO	exo2	physical	23319050
HSP90_SCHPO	hsp90	physical	23319050
YE38_SCHPO	pdc1	physical	23319050
EDC3_SCHPO	edc3	physical	24862735
ATG11_SCHPO	atg11	physical	26771498
CBH1_SCHPO	cbh1	physical	26771498
PAT1_SCHPO	SPBC19G7.10c	physical	26771498
DCP1_SCHPO	dcp1	physical	26771498
RPB3_SCHPO	rpb3	physical	26771498
RNG3_SCHPO	rng3	physical	26771498
DCP1_SCHPO	dcp1	physical	22085934
YAQ9_SCHPO	SPAC18G6.09c	physical	27354705

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.