PAT1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAT1_SCHPO
• UniProt AC: O42958
• Protein Name: DNA topoisomerase 2-associated protein pat1
• Gene Name: SPBC19G7.10c
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 754
• Subcellular Localization: Cytoplasm . Cytoplasm, P-body .
• Protein Description: Activator of decapping that functions as a general and active mechanism of translational repression and required for P-body formation. Stabilizes the 3' terminus of mRNAs and modulates the rates of mRNA-decapping that occur following deadenylation. Might be required for promoting the formation or the stabilization of the preinitiation translation complexes. Necessary for accurate chromosome transmission during cell division (By similarity)..
• Protein Sequence: MSFFGFNTTLPKENMFPNEGQLEEDGIDFEETYDDLGNQLNEAGDELNDETFGVSAGSIGRDFDFSGTTAQASAQLEDEQYQINQQNIFAKPVKPASSELPQVSRLNGASQFPSREPASTAINKLSDLQPMASIWENIVPEKPAIIPPEVASLQDRLGAQPSEKVFSLQELEEQLLNSMTAPKPPSQPAIPIVPSEMAAQVTRENISSLDPAISAASIGNVTFGQPNIPSTTTDFAGLAAPNMVHPSQAIPNPVMQPSLVPQMPYPQNGMYNPSVAPPASLVNLFQQEQLIQNQNLDEKRQKLERDHMLMAQCAGLMTRSDKSFIARIQISQLMSEDPESDDFYYRVYSIIRGRKPSEEEASHFIQTYLGPSNNRRRGRRSENPMQKLQQQLQRLVSSAKERPKATQLSLEGALGKIAVNTVRTPRQLLNVKRPTEPASSNSSLNNFSGFSTKKDVLHAIEKVYDLLLDFEQALRKASTLETTDQEQIDTWKTTLSEKLESIWKALYINESLEASSKTRPPFISIISHPKGMRLLPRLFPHLSKEQQISILKVVVYNFDSLDIVLRGTFDVNGELPLDVVSEMSSFTQFIIPPLLTIVNELDLETINNLFSQLLNRTNAVYLIQTKIGLSFLTLFISRAEILKQSGTVNQNEKEEWENTFNVMFNRVKGHFSTVFPPPNARAYADESYPWEFLAACATAASSEQHFTLVSETRDRVLDNIITSKRAPSEIAVVRISNVNLFLNAMGLDARQLSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
162	Phosphorylation	DRLGAQPSEKVFSLQ HHHCCCCCHHCCCHH	37.66	24763107
323	Phosphorylation	LMTRSDKSFIARIQI HCCCCCHHHHHHHHH	27.20	25720772
435	Phosphorylation	LLNVKRPTEPASSNS HHCCCCCCCCCCCCC	59.64	21712547
439	Phosphorylation	KRPTEPASSNSSLNN CCCCCCCCCCCCCCC	40.54	24763107
440	Phosphorylation	RPTEPASSNSSLNNF CCCCCCCCCCCCCCC	42.72	21712547
442	Phosphorylation	TEPASSNSSLNNFSG CCCCCCCCCCCCCCC	37.84	24763107
443	Phosphorylation	EPASSNSSLNNFSGF CCCCCCCCCCCCCCC	39.09	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAT1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAT1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAT1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCP1_SCHPO	dcp1	physical	26771498
LSM1_SCHPO	lsm1	physical	26771498
DHH1_SCHPO	ste13	physical	26771498
AP1M1_SCHPO	apm1	physical	26771498
LSM2_SCHPO	lsm2	physical	26771498
LSM7_SCHPO	lsm7	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.