YE38_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YE38_SCHPO
• UniProt AC: O13892
• Protein Name: Uncharacterized protein C20G4.08
• Gene Name: SPAC20G4.08, SPAC4F10.01
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1076
• Protein Sequence: MNEQDLLNSLRRDLNLPNLGKSHDGSEAVESTFPEKKESSLSAQQPHVDDQRSSLLSLLNAGLNASNQSPSNSGPKYYASHSSSTDALLQAFRDGAKPSGTASGADVKRSDSESTEATSNERPFNPVSAANLERLLMSSTGPQTPINGELKSNDSQDTAFQSSRNMPSDTSVASPDYSHSQSSSPIANYQESGNSEEPHKAEEQQQLSIYQLDNPGSGNYVWETVISPDKFETSTFAKCERNDIAIINRELDAQDNQLIHTNEDFIAYAVHREPIIRVIEISTGKSFLLHNNSPNKFVSVAWGNDSVIKNRLMAIDTTGQVLIFAVDIATSTSEIIFQLSGAQSLSDPIKSRFHWYPKSSTRFAVALSKHIIFFDLDLLNNISFPIPRSINAIQQLPCFLIDTGISAKEYDFSYDGTVFATVDKDALIKIYTVPTTFPSTPDKRPVPSEVSPIAIFTTRMERGPSKNYEKPINLRFISTPGTNNSRYLVIVYVMNQLITLFDLYSKRNIQTFRFNNRPTAATTTSFSQFSVDNERSTLLVGNPPSNSIYFFLFAKDETVSEQAPIYNSTYELILASLNTSEPVPADAKFSVIVAKKFEKAACISFTACKILESEDKYCIVVSNTDGYEYYSIPTSILDKTGKTVRSLESVQNYDADIGGTIDLTERHSTASPSTVNSGFSTPRSQATGFSKKKKDKGERFETKDKSSSVLSPSSYSASTFDAIPMDSIVSNILASLEKSVHKNYESLRSQLLEYKAANEKHTEAILSVVSSTLTENTGKILESVVEKSMQVALKEEIANSVRNALKNNLEKIESFLENSIAELQNSVREDFDKQTSSLAQLRYSIQNVAHAQKESEVKYNELNEQVKTLEGYVETVLEKFNDLKIENKVPETAPDVVPSSYPPAAESNVSVSSDTSTKDVEKQEPSSAEQPAQGIAESLRRLKEYVKAGSVKECVAEWCNMPSVAGFDVLSEISYDRMLENCSNLLLLTFIYHISLLDSVDDDRLSKRMEYISRICLNIDVNDPKVETVVHPVLTLTREALLRQSEFFSPIFKRRLVVLLRALDGKISEISVASSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	NLPNLGKSHDGSEAV CCCCCCCCCCCCHHH	25.64	24763107
26	Phosphorylation	LGKSHDGSEAVESTF CCCCCCCCHHHHHHC	28.56	25720772
39	Phosphorylation	TFPEKKESSLSAQQP HCCCHHHHCCCCCCC	45.52	29996109
40	Phosphorylation	FPEKKESSLSAQQPH CCCHHHHCCCCCCCC	27.69	29996109
66	Phosphorylation	LNAGLNASNQSPSNS HHHHCCCCCCCCCCC	34.04	25720772
69	Phosphorylation	GLNASNQSPSNSGPK HCCCCCCCCCCCCCC	34.25	25720772
71	Phosphorylation	NASNQSPSNSGPKYY CCCCCCCCCCCCCCE	49.20	25720772
73	Phosphorylation	SNQSPSNSGPKYYAS CCCCCCCCCCCCEEC	61.89	25720772
77	Phosphorylation	PSNSGPKYYASHSSS CCCCCCCCEECCCCC	13.85	21712547
78	Phosphorylation	SNSGPKYYASHSSST CCCCCCCEECCCCCH	14.04	25720772
80	Phosphorylation	SGPKYYASHSSSTDA CCCCCEECCCCCHHH	14.05	24763107
82	Phosphorylation	PKYYASHSSSTDALL CCCEECCCCCHHHHH	24.40	24763107
83	Phosphorylation	KYYASHSSSTDALLQ CCEECCCCCHHHHHH	31.65	24763107
84	Phosphorylation	YYASHSSSTDALLQA CEECCCCCHHHHHHH	33.06	21712547
85	Phosphorylation	YASHSSSTDALLQAF EECCCCCHHHHHHHH	27.52	21712547
110	Phosphorylation	SGADVKRSDSESTEA CCCCCCCCCCCCCCC	39.51	28889911
112	Phosphorylation	ADVKRSDSESTEATS CCCCCCCCCCCCCCC	34.39	29996109
114	Phosphorylation	VKRSDSESTEATSNE CCCCCCCCCCCCCCC	35.18	25720772
115	Phosphorylation	KRSDSESTEATSNER CCCCCCCCCCCCCCC	26.11	29996109
119	Phosphorylation	SESTEATSNERPFNP CCCCCCCCCCCCCCC	43.68	28889911
139	Phosphorylation	LERLLMSSTGPQTPI HHHHHHCCCCCCCCC	24.34	25720772
140	Phosphorylation	ERLLMSSTGPQTPIN HHHHHCCCCCCCCCC	45.64	25720772
144	Phosphorylation	MSSTGPQTPINGELK HCCCCCCCCCCCCCC	29.30	25720772
152	Phosphorylation	PINGELKSNDSQDTA CCCCCCCCCCCCCCH	59.50	25720772
155	Phosphorylation	GELKSNDSQDTAFQS CCCCCCCCCCCHHHH	33.92	25720772
162	Phosphorylation	SQDTAFQSSRNMPSD CCCCHHHHHCCCCCC	25.47	25720772
174	Phosphorylation	PSDTSVASPDYSHSQ CCCCCCCCCCCCCCC	19.02	27738172
184	Phosphorylation	YSHSQSSSPIANYQE CCCCCCCCCCCCCCC	26.10	27738172
668	Phosphorylation	IDLTERHSTASPSTV EECCCCCCCCCCCCC	31.71	25720772
669	Phosphorylation	DLTERHSTASPSTVN ECCCCCCCCCCCCCC	25.65	29996109
671	Phosphorylation	TERHSTASPSTVNSG CCCCCCCCCCCCCCC	21.33	28889911
673	Phosphorylation	RHSTASPSTVNSGFS CCCCCCCCCCCCCCC	42.36	28889911
674	Phosphorylation	HSTASPSTVNSGFST CCCCCCCCCCCCCCC	27.39	28889911
677	Phosphorylation	ASPSTVNSGFSTPRS CCCCCCCCCCCCCCH	36.56	28889911
680	Phosphorylation	STVNSGFSTPRSQAT CCCCCCCCCCCHHCC	40.81	29996109
681	Phosphorylation	TVNSGFSTPRSQATG CCCCCCCCCCHHCCC	22.06	28889911
913	Phosphorylation	ESNVSVSSDTSTKDV CCCEEECCCCCCCCH	42.63	21712547
915	Phosphorylation	NVSVSSDTSTKDVEK CEEECCCCCCCCHHH	40.00	21712547
916	Phosphorylation	VSVSSDTSTKDVEKQ EEECCCCCCCCHHHC	38.15	21712547
1074	Phosphorylation	ISEISVASSN----- CEEEEEECCC-----	28.40	24763107
1075	Phosphorylation	SEISVASSN------ EEEEEECCC------	36.50	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YE38_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YE38_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YE38_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCP2_SCHPO	dcp2	physical	23319050
DCP1_SCHPO	dcp1	physical	23319050
EDC3_SCHPO	edc3	physical	23319050
DHH1_SCHPO	ste13	physical	23319050
XRN1_SCHPO	exo2	physical	23319050
YE38_SCHPO	pdc1	physical	23319050
EDC3_SCHPO	edc3	physical	24862735
PAT1_SCHPO	SPBC19G7.10c	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-671; SER-673; THR-674AND SER-1075, AND MASS SPECTROMETRY.
PubMed: 18257517