EDC3_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EDC3_SCHPO
• UniProt AC: O94752
• Protein Name: Enhancer of mRNA-decapping protein 3
• Gene Name: edc3
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 454
• Subcellular Localization: Cytoplasm, P-body . Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay..
• Protein Description: Stimulates decapping of both stable and unstable mRNA during mRNA decay. Stimulates decapping presumably by preventing the DCP1-DCP2 decapping complex from adopting an inactive conformation..
• Protein Sequence: MSVADFYGSNVEVLLNNDSKARGVITNFDSSNSILQLRLANDSTKSIVTKDIKDLRILPKNEIMPKNGTKSPSTNSTKLKSAETYSSKNKWSMDCDEEFDFAANLEKFDKKQVFAEFREKDKKDPAKLLVSHNKSPNRNYHHKQNVLGPSVKDEFVDLPSAGSQINGIDAVLSSSSNGHVTPGSKKGSRETLKKKPFVDENIPAELHTTTGDILKPITPEQLSQGIALAIAKTSTDIVVENAAQLLSQFVFSVLGGHKRLSSRNHNSQPLVCILVGSHDHASAAVAAGRRLCAIGIKVVLRLLTPFNVDNRQLLMFQAAGGYIPTENFDQFLNKLTSPIELVVDVLTGFHPSIDKNSHALIQWANDLNVLILSVDIPSGYTVQKKNTAILPKWTLALGAVTTTLAQAALVKQAAGVSVFVGNLGTGSQTWAELGILESQVTGQYLAQISCTSTN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
131	Phosphorylation	DPAKLLVSHNKSPNR CHHHHEECCCCCCCC	22.70	29996109
135	Phosphorylation	LLVSHNKSPNRNYHH HEECCCCCCCCCCCC	32.50	28889911
163	Phosphorylation	VDLPSAGSQINGIDA CCCCCCCCCCCCCCE	27.83	29996109
173	Phosphorylation	NGIDAVLSSSSNGHV CCCCEEEECCCCCCC	22.90	29996109
174	Phosphorylation	GIDAVLSSSSNGHVT CCCEEEECCCCCCCC	33.36	29996109
175	Phosphorylation	IDAVLSSSSNGHVTP CCEEEECCCCCCCCC	25.17	29996109
176	Phosphorylation	DAVLSSSSNGHVTPG CEEEECCCCCCCCCC	49.10	29996109
181	Phosphorylation	SSSNGHVTPGSKKGS CCCCCCCCCCCCCCC	19.09	21712547
184	Phosphorylation	NGHVTPGSKKGSRET CCCCCCCCCCCCHHH	32.19	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EDC3_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EDC3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EDC3_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCP2_SCHPO	dcp2	physical	22085934

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.