CTDS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTDS1_HUMAN
• UniProt AC: Q9GZU7
• Protein Name: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
• Gene Name: CTDSP1
• Organism: Homo sapiens (Human).
• Sequence Length: 261
• Subcellular Localization: Nucleus . Colocalizes with RNA polymerase II.
• Protein Description: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells..
• Protein Sequence: MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDSSAVIT -------CCCCCEEE	11.56	22814378
3	Phosphorylation	-----MDSSAVITQI -----CCCCCEEEEC	20.92	29083192
4	Phosphorylation	----MDSSAVITQIS ----CCCCCEEEECC	23.45	29083192
8	Phosphorylation	MDSSAVITQISKEEA CCCCCEEEECCHHHH	17.16	29083192
11	Phosphorylation	SAVITQISKEEARGP CCEEEECCHHHHCCC	24.97	29083192
22	Acetylation	ARGPLRGKGDQKSAA HCCCCCCCCCHHHHH	53.53	30587915
26	Acetylation	LRGKGDQKSAASQKP CCCCCCHHHHHHCCC	46.96	30587921
27	Phosphorylation	RGKGDQKSAASQKPR CCCCCHHHHHHCCCC	24.35	28857561
30	Phosphorylation	GDQKSAASQKPRSRG CCHHHHHHCCCCHHC	38.15	28857561
32	Ubiquitination	QKSAASQKPRSRGIL HHHHHHCCCCHHCCH	39.64	-
41	O-linked_Glycosylation	RSRGILHSLFCCVCR CHHCCHHHHEEEEEC	21.50	25081999
44	S-palmitoylation	GILHSLFCCVCRDDG CCHHHHEEEEECCCC	1.74	28440748
45	S-palmitoylation	ILHSLFCCVCRDDGE CHHHHEEEEECCCCC	2.25	28440748
47	S-palmitoylation	HSLFCCVCRDDGEAL HHHEEEEECCCCCCC	2.17	28440748
74	Phosphorylation	NGAIPKQTPVQYLLP CCCCCCCCCHHHHCC	31.39	22199227
78	Phosphorylation	PKQTPVQYLLPEAKA CCCCCHHHHCCHHHC	15.50	26657352
83	Ubiquitination	VQYLLPEAKAQDSDK HHHHCCHHHCCCCCC	15.56	29967540
84	Ubiquitination	QYLLPEAKAQDSDKI HHHCCHHHCCCCCCE	44.94	21906983
180	Phosphorylation	RARLFRESCVFHRGN HHHHHHHHCCEECCC	16.01	24719451
188	Phosphorylation	CVFHRGNYVKDLSRL CCEECCCHHHHHHHH	16.23	24719451
245	Phosphorylation	LPFFEQLSRVDDVYS HHHHHHHCCCCHHHH	29.92	-
251	Phosphorylation	LSRVDDVYSVLRQPR HCCCCHHHHHHCCCC	10.47	28796482
252	Phosphorylation	SRVDDVYSVLRQPRP CCCCHHHHHHCCCCC	17.96	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CTDS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CTDS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTDS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDCA3_HUMAN	CDCA3	physical	16189514
RPB1_HUMAN	POLR2A	physical	12721286
SNAI1_HUMAN	SNAI1	physical	19004823
CDCA3_HUMAN	CDCA3	physical	25416956
CTDS2_HUMAN	CTDSP2	physical	26186194
CTDSL_HUMAN	CTDSPL	physical	26186194
TBB8_HUMAN	TUBB8	physical	26186194
TBB1_HUMAN	TUBB1	physical	26186194
HEAT6_HUMAN	HEATR6	physical	26186194
DUSTY_HUMAN	DSTYK	physical	26186194
TBA4A_HUMAN	TUBA4A	physical	26186194
TBA1A_HUMAN	TUBA1A	physical	26186194
CDCA3_HUMAN	CDCA3	physical	26186194
F118B_HUMAN	FAM118B	physical	26186194
REST_HUMAN	REST	physical	25197063
CDCA3_HUMAN	CDCA3	physical	27880917
TAB2_HUMAN	TAB2	physical	27880917
CDCA3_HUMAN	CDCA3	physical	28514442
CTDS2_HUMAN	CTDSP2	physical	28514442
CTDSL_HUMAN	CTDSPL	physical	28514442
TBB1_HUMAN	TUBB1	physical	28514442
DUSTY_HUMAN	DSTYK	physical	28514442
F118B_HUMAN	FAM118B	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
TBA1A_HUMAN	TUBA1A	physical	28514442
TIM10_HUMAN	TIMM10	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.