CD40L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD40L_HUMAN
• UniProt AC: P29965
• Protein Name: CD40 ligand
• Gene Name: CD40LG
• Organism: Homo sapiens (Human).
• Sequence Length: 261
• Subcellular Localization: Cell membrane ; Single-pass type II membrane protein . Cell surface .; CD40 ligand, soluble form: Secreted .
• Protein Description: Cytokine that binds to CD40/TNFRSF5. [PubMed: 1280226 Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation]
• Protein Sequence: MIETYNQTSPRSAATGLPISMKIFMYLLTVFLITQMIGSALFAVYLHRRLDKIEDERNLHEDFVFMKTIQRCNTGERSLSLLNCEEIKSQFEGFVKDIMLNKEETKKENSFEMQKGDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MIETYNQTSPR ----CCCCCCCCCCC	19.49	28796482
5	Phosphorylation	---MIETYNQTSPRS ---CCCCCCCCCCCH	7.77	28796482
26	Phosphorylation	ISMKIFMYLLTVFLI HHHHHHHHHHHHHHH	6.44	22210691
29	Phosphorylation	KIFMYLLTVFLITQM HHHHHHHHHHHHHHH	13.45	22210691
154	Phosphorylation	TMSNNLVTLENGKQL EEECCEEEEECCEEE	31.36	22210691
162	Phosphorylation	LENGKQLTVKRQGLY EECCEEEEEEECEEE	22.84	23532336
169	Phosphorylation	TVKRQGLYYIYAQVT EEEECEEEEEEEEEE	8.47	24043423
170	Phosphorylation	VKRQGLYYIYAQVTF EEECEEEEEEEEEEE	7.78	24043423
172	Phosphorylation	RQGLYYIYAQVTFCS ECEEEEEEEEEEECC	3.78	24043423
176	Phosphorylation	YYIYAQVTFCSNREA EEEEEEEEECCCCCH	13.57	24043423
179	Phosphorylation	YAQVTFCSNREASSQ EEEEEECCCCCHHCC	34.43	24043423
240	N-linked_Glycosylation	PGASVFVNVTDPSQV CCCEEEEEECCHHHC	21.36	11676606
240	N-linked_Glycosylation	PGASVFVNVTDPSQV CCCEEEEEECCHHHC	21.36	11676606

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RNF128	Q8TEB7	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD40L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD40L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HPTR_HUMAN	HPR	physical	10085035
APOA1_HUMAN	APOA1	physical	10085035
RN128_HUMAN	RNF128	physical	18641297
TNR5_HUMAN	CD40	physical	23918987
TRAF2_HUMAN	TRAF2	physical	23918987
BIRC2_HUMAN	BIRC2	physical	23918987
BIRC3_HUMAN	BIRC3	physical	23918987
TRAF1_HUMAN	TRAF1	physical	23918987

Drug and Disease Associations

• Kegg Disease
• H00080: Systemic lupus erythematosus
• H00093: Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndro
• OMIM Disease
• 308230: X-linked immunodeficiency with hyper-IgM 1 (HIGM1)
• Kegg Drug
• D05777: Ruplizumab (USAN/INN)
• D06193: Toralizumab (USAN/INN)
• DrugBank
• There are no disease associations of PTM sites.