HPTR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HPTR_HUMAN
• UniProt AC: P00739
• Protein Name: Haptoglobin-related protein
• Gene Name: HPR
• Organism: Homo sapiens (Human).
• Sequence Length: 348
• Subcellular Localization: Secreted . Secreted into blood plasma and associated with subtypes of high density lipoproteins (HDL).
• Protein Description: Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron..
• Protein Sequence: MSDLGAVISLLLWGRQLFALYSGNDVTDISDDRFPKPPEIANGYVEHLFRYQCKNYYRLRTEGDGVYTLNDKKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYHQVDIGLIKLKQKVLVNERVMPICLPSKNYAEVGRVGYVSGWGQSDNFKLTDHLKYVMLPVADQYDCITHYEGSTCPKWKAPKSPVGVQPILNEHTFCVGMSKYQEDTCYGDAGSAFAVHDLEEDTWYAAGILSFDKSCAVAEYGVYVKVTSIQHWVQKTIAEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDLGAVIS ------CCHHHHHHH	41.35	24043423
9	Phosphorylation	SDLGAVISLLLWGRQ CHHHHHHHHHHHHHH	13.33	24043423
21	Phosphorylation	GRQLFALYSGNDVTD HHHHHHHHCCCCCCC	15.88	24043423
22	Phosphorylation	RQLFALYSGNDVTDI HHHHHHHCCCCCCCC	31.78	24043423
27	Phosphorylation	LYSGNDVTDISDDRF HHCCCCCCCCCCCCC	30.40	24043423
30	Phosphorylation	GNDVTDISDDRFPKP CCCCCCCCCCCCCCC	35.95	24043423
67	Phosphorylation	RTEGDGVYTLNDKKQ EECCCCEEECCCHHH	15.84	21253578
72	Glycation	GVYTLNDKKQWINKA CEEECCCHHHHHHHH	45.87	-
112	Acetylation	LGGHLDAKGSFPWQA HCCCCCCCCCCCCCE	55.54	7666893
211	Phosphorylation	VMPICLPSKNYAEVG EECEECCCCCCEEEC	22.15	24719451
328	Phosphorylation	KSCAVAEYGVYVKVT CCCEEEECEEEEEEE	11.36	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HPTR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HPTR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HPTR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ICP27_HHV8P	ORF57	physical	18974867

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.