| UniProt ID | ICP27_HHV8P | |
|---|---|---|
| UniProt AC | Q2HR75 | |
| Protein Name | mRNA export factor ICP27 homolog | |
| Gene Name | ORF57 | |
| Organism | Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus). | |
| Sequence Length | 455 | |
| Subcellular Localization | Host cytoplasm. Host nucleus. Shuttles between the nucleus and the cytoplasm. | |
| Protein Description | Early protein that promotes the accumulation and nuclear export of viral intronless RNA transcripts by interacting with mRNAs and cellular export proteins. Probably acts as a viral splicing factor that regulates viral RNA splicing. Functions as a multifunctional regulator of the expression of viral lytic genes.. | |
| Protein Sequence | MVQAMIDMDIMKGILEDSVSSSEFDESRDDETDAPTLEDEQLSEPAEPPADERIRGTQSAQGIPPPLGRIPKKSQGRSQLRSEIQFCSPLSRPRSPSPVNRYGKKIKFGTAGQNTRPPPEKRPRRRPRDRLQYGRTTRGGQCRAAPKRATRRPQVNCQRQDDDVRQGVSDAVKKLRLPASMIIDGESPRFDDSIIPRHHGACFNVFIPAPPSHVPEVFTDRDITALIRAGGKDDELINKKISAKKIDHLHRQMLSFVTSRHNQAYWVSCRRETAAAGGLQTLGAFVEEQMTWAQTVVRHGGWFDEKDIDIILDTAIFVCNAFVTRFRLLHLSCVFDKQSELALIKQVAYLVAMGNRLVEACNLLGEVKLNFRGGLLLAFVLTIPGMQSRRSISARGQELFRTLLEYYRPGDVMGLLNVIVMEHHSLCRNSECAAATRAAMGSAKFNKGLFFYPLS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of ICP27_HHV8P !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ICP27_HHV8P !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ICP27_HHV8P !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ICP27_HHV8P !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NCBP1_HUMAN | NCBP1 | physical | 18974867 | |
| THOC4_HUMAN | ALYREF | physical | 18974867 | |
| DX39B_HUMAN | DDX39B | physical | 18974867 | |
| THOC5_HUMAN | THOC5 | physical | 18974867 | |
| HPTR_HUMAN | HPR | physical | 18974867 | |
| IF4A3_HUMAN | EIF4A3 | physical | 18974867 | |
| SRSF3_HUMAN | SRSF3 | physical | 18974867 | |
| ICP27_HHV8P | ORF57 | physical | 17609285 | |
| THOC4_HUMAN | ALYREF | physical | 17609285 | |
| PAP_HHV8P | ORF59 | physical | 17609285 | |
| BRD4_HUMAN | BRD4 | physical | 25544563 | |
| BRD2_HUMAN | BRD2 | physical | 25544563 | |
| IFT81_HUMAN | IFT81 | physical | 25544563 | |
| BUD23_HUMAN | WBSCR22 | physical | 25544563 | |
| UBE2O_HUMAN | UBE2O | physical | 25544563 | |
| GTPB1_HUMAN | GTPBP1 | physical | 25544563 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
