dbPTM

PAP_HHV8P - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PAP_HHV8P
UniProt AC	F5HID2
Protein Name	DNA polymerase processivity factor
Gene Name	ORF59
Organism	Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus).
Sequence Length	396
Subcellular Localization	Virion tegument. Host nucleus.
Protein Description	Plays an essential role in the viral lytic DNA replication by acting as the polymerase accessory subunit. Stimulates the viral DNA polymerase activity and appears to function with it as a holoenzyme. Increases the processivity of the viral polymerase, probably by acting as a sliding clamp that prevents dissociation of the polymerase from the active template (By similarity)..
Protein Sequence	MPVDFHYGVRVDVTLLSKIRRVNEHIKSATKTGVVQVHGSACTPTLSVLSSVGTAGVLGLRIKNALTPLVGHTEGSGDVSFSFRNTSVGSGFTHTRELFGANVLDAGIAFYRKGEACDTGAQPQFVRTTISYGDNLTSTVHKSVVDQKGILPFHDRMEAGGRTTRLLLCGKTGAFLLKWLRQQKTKEDQTVTVSVSETLSIVTFSLGGVSKIIDFKPETKPVSGWDGLKGKKSVDVGVVHTDALSRVSLESLIAALRLCKVPGWFTPGLIWHSNEILEVEGVPTGCQSGDVKLSVLLLEVNRSVSAEGGESSQKVPDSIPDSRRQPELESPDSPPLTPVGPFGPLEDASEDAASVTSCPPAAPTKDSTKRPHKRRSDSSQSRDRGKVPKTTFNPLI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of PAP_HHV8P !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PAP_HHV8P !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PAP_HHV8P !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PAP_HHV8P !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBP_HUMAN	TBP	physical	25544563
SURF6_HUMAN	SURF6	physical	25544563
SRRM1_HUMAN	SRRM1	physical	25544563
PHF8_HUMAN	PHF8	physical	25544563

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PAP_HHV8P

Related Literatures of Post-Translational Modification