BLM_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BLM_DROME
• UniProt AC: Q9VGI8
• Protein Name: Bloom syndrome protein homolog
• Gene Name: Blm
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1487
• Subcellular Localization: Nucleus.
• Protein Description: Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity).; ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. Participates in DNA replication and repair. Negatively regulates sister chromatid exchange (SCE). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction..
• Protein Sequence: MSKKPVAQRKQLTLSSFIGLDGNSQSQPKSRAASVRSKPPAVYNPIFLDASSSDDETTEISSQSNNGTIATKKSSRDPRTAKLKKHTYLDLSVSPLAKLSAKKYARDSPKKPTSLDLSVSPLAELLAKKSDRDSPKKPVQNENSYTYRGLSESPVENKSIGDTLRKPPQKERKTSIVWLSDSPEKKVTQNERKILDSPLQRFSFEDFPNKENGNRHHLLTLPDSPPPPQPVKKPEKTMWQNETKTIQDKDSPANPLVSNNLASISTLLDSSRAPNTYKGSSRNLFEDSPEKSGSGEQGYKLGSAKENEIPTKPATASLERNSVTSSPSPAAPLKPRYSVAFDNSLADYLKDLAQNDNFSIDPNKQNTETLKSTLGFFRNTYVELMEKYCSLIDQIPAMHFNEIAGFQPNTFLKLKVMRQKFKARTQLVQNSLDKKESQLKAEQEALEKEEIEMQAEQAQQTVLSSSSPEKSRPIMPLPKVQEIKDEKIPNRNQLIHDLCGEPDNFSPPSSPRDTQLIPKRQQLINDLCGEPDDFSPPSKQNDPHLLRKCEELVHDLCEEPDDYLAQSMMLDGDLEEEQLNGPTQGTTTSGMDDDEDDLEGLLAEIEDEHQKMQGRRSEFNGYSYKELEAVKVKEKHKETPINISLDDDGFPEYDEAMFEQMHSQAAANKSRVSSAGPSTSKSVVPTKQTSALHSQKLSGNFHANVHNDGITGEFDGQKFEHSTRLMHGLSYSFGLKSFRPNQLQVINATLLGNDCFVLMPTGGGKSLCYQLPAILTEGVTIVISPLKSLIFDQINKLASLDICAKSLSGEQKMADVMAIYRDLESQPPMVKLLYVTPEKISSSARFQDTLDTLNSNNYISRFVIDEAHCVSQWGHDFRPDYKKLGVLKKRFPNVPTIALTATATPRVRLDILAQLNLKNCKWFLSSFNRSNLRYRVLPKKGVSTLDDISRYIRSKPQHFSGIIYCLSRKECDETSKKMCKDGVRAVSYHAGLTDTDRESRQKDWLTGKMRVICATVAFGMGIDKPDVRFVLHYSLPKSIEGYYQEAGRAGRDGDVADCILYYNYSDMLRIKKMLDSDKALQYNVKKIHVDNLYRIVGYCENLTDCRRAQQLDYFGEHFTSEQCLENRETACDNCINKRAYKAVDALEHARKAARAVKDLCSGRSRFTLLHIADVLKGSKIKKIIDFNHHKTPHHGVLKDWDKNDVHRLLRKMVIDGFLREDLIFTNDFPQAYLYLGNNISKLMEGTPNFEFAVTKNAKEAKAAVGSVSDGATSSTADGQSGMREIHERCYTDLLDLCRTIASQRNVTMASIMNIQALKSMAETLPITEKDMCSIPHVTKANFDKYGAKLLEITSNYASEKLLMQAVLDEEEEQAAAKQRPSTSGWNNESVDWDMAVASQGNANTSGASGFNSFRAGKRKKIYKSGASKRYKTSTTSPAARKTTSARGRGGRAGAKRAESSASSASGWKSKKTGNSFGFDLMPLPGSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	NPIFLDASSSDDETT CCEEEECCCCCCCCC	30.00	22817900
52	Phosphorylation	PIFLDASSSDDETTE CEEEECCCCCCCCCC	39.23	22817900
53	Phosphorylation	IFLDASSSDDETTEI EEEECCCCCCCCCCC	46.73	22817900
92	Phosphorylation	KHTYLDLSVSPLAKL CCEEEECCCHHHHHH	21.88	22817900
94	Phosphorylation	TYLDLSVSPLAKLSA EEEECCCHHHHHHHH	15.72	22817900
108	Phosphorylation	AKKYARDSPKKPTSL HHHHCCCCCCCCCCC	32.82	22817900
113	Phosphorylation	RDSPKKPTSLDLSVS CCCCCCCCCCCCCHH	51.29	18327897
118	Phosphorylation	KPTSLDLSVSPLAEL CCCCCCCCHHHHHHH	21.88	22817900
120	Phosphorylation	TSLDLSVSPLAELLA CCCCCCHHHHHHHHH	15.72	22817900
130	Phosphorylation	AELLAKKSDRDSPKK HHHHHHCCCCCCCCC	36.85	22817900
134	Phosphorylation	AKKSDRDSPKKPVQN HHCCCCCCCCCCCCC	39.24	22817900
151	Phosphorylation	SYTYRGLSESPVENK CCCCCCCCCCCCCCC	38.56	19429919
153	Phosphorylation	TYRGLSESPVENKSI CCCCCCCCCCCCCCH	30.76	19429919
175	Phosphorylation	PQKERKTSIVWLSDS CCCCCCCEEEEECCC	20.41	22817900
180	Phosphorylation	KTSIVWLSDSPEKKV CCEEEEECCCCCCCC	21.96	22817900
182	Phosphorylation	SIVWLSDSPEKKVTQ EEEEECCCCCCCCCH	31.42	25749252
197	Phosphorylation	NERKILDSPLQRFSF HHHHHCCCCHHHCCC	24.86	19429919
203	Phosphorylation	DSPLQRFSFEDFPNK CCCHHHCCCCCCCCC	29.89	22817900
224	Phosphorylation	HLLTLPDSPPPPQPV EEEECCCCCCCCCCC	37.05	19429919
245	Phosphorylation	MWQNETKTIQDKDSP CCCCCCCCCCCCCCC	31.15	28490779
251	Phosphorylation	KTIQDKDSPANPLVS CCCCCCCCCCCCCCC	31.49	19429919
258	Phosphorylation	SPANPLVSNNLASIS CCCCCCCCCCHHHHH	27.90	19429919
288	Phosphorylation	SRNLFEDSPEKSGSG CCCCCCCCCCCCCCC	27.97	19429919
326	Phosphorylation	ERNSVTSSPSPAAPL HHCCCCCCCCCCCCC	21.74	22817900
328	Phosphorylation	NSVTSSPSPAAPLKP CCCCCCCCCCCCCCC	29.17	22817900
467	Phosphorylation	QTVLSSSSPEKSRPI HHHHHCCCCCCCCCC	38.74	30478224
506	Phosphorylation	CGEPDNFSPPSSPRD CCCCCCCCCCCCHHH	42.00	22817900
509	Phosphorylation	PDNFSPPSSPRDTQL CCCCCCCCCHHHCCC	57.25	22817900
510	Phosphorylation	DNFSPPSSPRDTQLI CCCCCCCCHHHCCCC	29.72	22817900
535	Phosphorylation	CGEPDDFSPPSKQND CCCCCCCCCCHHCCC	42.78	22817900
617	Phosphorylation	QKMQGRRSEFNGYSY HHHCCCCCCCCCCCH	45.22	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BLM_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BLM_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BLM_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OTU_DROME	otu	physical	15710747
PANG1_DROME	pan	physical	15710747
PANG2_DROME	pan	physical	15710747
DORS_DROME	dl	physical	15710747
COPG_DROME	gammaCOP	physical	15710747
LIMK1_DROME	LIMK1	physical	15710747
SPS1_DROME	SelD	physical	15710747
RAD54_DROME	okr	genetic	10454573
KU70_DROME	Irbp	genetic	8608940
KU70_DROME	Irbp	genetic	11283371
OTP_DROME	otp	physical	25242320

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52; SER-53; SER-92;SER-94; SER-108; THR-113; SER-118; SER-120; SER-130; SER-151; SER-153;SER-180; SER-182; SER-197; SER-203; SER-328; SER-506; SER-509; SER-510AND SER-535, AND MASS SPECTROMETRY.
PubMed: 18327897