COPG_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COPG_DROME
• UniProt AC: Q8I0G5
• Protein Name: Coatomer subunit gamma {ECO:0000250|UniProtKB:P53620, ECO:0000312|EMBL:AAN14275.1}
• Gene Name: gammaCOP {ECO:0000312|FlyBase:FBgn0028968}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 883
• Subcellular Localization: Cytoplasm . Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle, COPI-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Endoplasmic reticulum . The coatomer is cytoplasmic or polyme
• Protein Description: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. Involved in the expansion of luminal extracellular matrices and apical membrane during tubulogenesis. Required in the tracheal epithelium for luminal protein secretion and diametric tube growth. In salivary glands, required for deposition of O-glycans and luminal extracellular matrix assembly. Required for epidermal morphogenesis and cuticle development..
• Protein Sequence: MNYFSLTSHKKHRGHPSAGPSNAYQNLEKTSVLQETRTFNETPVNPRKCIHILTKILYLINQGEQLVAREATDCFFAMTKLFQSKDVVLRRMVYLGIKELSSIAEDVIIVTSSLTKDMTGKEDLYRAAAIRALCSITDNTMLQAVERYMKQCIVDKNAAVSCAALVSSLRLANTAGDVVKRWANEAQEALNSDNIMVQYHALGLLYHIRKSDRLAVSKLVNKLTRGSLKSPYAVCMLIRIACKLIEEEDIPSEELSDSPLFTFIESCLRHKSEMVIYEAAHAIVNLKNTNPRMLSPAFSILQLFCSSPKATLRFAAVRTLNKVAMTHPAAVTTCNLDLEGLITDSNRSVATLAITTLLKTGAESSVERLMKQISTFVAEISDEFKVVVVQAICALCTKYPRKHTVLMNFLSGMLREEGGLEYKTSIVDTIITIIEENADAKESGLSHLCEFIEDCEHVSLAVRILHLLGKEGPFAATPSKYIRFIYNRVILESPIVRAAAVTAMAQFGASCPALLSNILVLLGRCQMDPDDEVRDRATYYLSILNSERPELYKNYIIERENCSLALLEKSLVEHLNGDVDTRFDISIVPKAAIVKPVIANDVMLVTSSAPRPPKITREEESAARLAQLPGIQVLGPIHRSTAPIQLTESETEYTVQCIKHIFGQHVVFQFDCLNTLSDQILENVRVELTLPEGFTTRAVIPCPKLPYNDLQTTFVIVEFPPDAANSIATFGATLRFVVKDCDPNTGEPESEEGYDDEYMLEDLELTVADQIQKTRKNNFQVSWDAADSEEWLQAEDTFVLSAVTTLQDAVNTIVKILGLGAANLSENVPEGTHLHTLLCSGTFRGGAEILVRAKLALSEGVTLNLTVRSTDQDVAELITAAIG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MNYFSLTSHKKHRG -CCCCCCCCCCCCCC	27.82	22817900
606	Phosphorylation	ANDVMLVTSSAPRPP ECCEEEEECCCCCCC	17.01	21082442
607	Phosphorylation	NDVMLVTSSAPRPPK CCEEEEECCCCCCCC	19.61	21082442
608	Phosphorylation	DVMLVTSSAPRPPKI CEEEEECCCCCCCCC	32.69	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COPG_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COPG_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COPG_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.