| UniProt ID | RAD54_DROME | |
|---|---|---|
| UniProt AC | O76460 | |
| Protein Name | DNA repair and recombination protein RAD54-like {ECO:0000303|PubMed:9315669} | |
| Gene Name | okr {ECO:0000312|EMBL:AAF51168.1, ECO:0000312|FlyBase:FBgn0002989} | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 784 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54.. | |
| Protein Sequence | MRRSLAPSQRGPLRPESRHSFTPPLLKKNKRSCQQELEREQELDRRRLGALRDASNTSELPLPIRFTANSEYELAIAKVLARKFKVPMDNYVPDYGGKRVLGVRRCISRRPLHDPMACNALVLFHPPAYTEHERMGMDPTKVLVHVVVDPLLSNILRPHQREGVRFMYECVEGKRGNFNGCIMADEMGLGKTLQCVTLVWTLLRQGPECKPTINKAIVVSPSSLVKNWEKEFTKWLHGRLLCLPMEGGTKENTIRALEQFSMTSARLGTPVLLISYETFRIYAEILCKYEVGMVICDEGHRLKNSDNLTYQALMGLKTKRRVLLSGTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAIEKTQELIGLVDQCIIRRTNQILTKYLPVKFEMVICAKLTAIQLELYTNFLKSDQVRRSLADCNEKASLTALADITTLKKICSHPDLIYEKLTAREKGFENSQNVLPSNYKPKDLNPELSGKFMLLDFMLAAIRAEGNDKVVLISNYTQTLDLFEQLARKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDSFLFMLSSKAGGCGLNLIGANRLFMFDPDWNPANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKSLSSTIIDNNESAEKHFTRDDLKDLFTFDANILSDTHDKLKCKRCVQNIQMKPPPEDTDCTSHLSQWYHCSNNRGLPDNILAQAWMDCKCVSFVFHHRSQAQEIVPSAEEEATDQPEEKPESRKRSSTPASDDSADEDFRGF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 20 | Phosphorylation | LRPESRHSFTPPLLK CCCCCCCCCCHHHHH | 29.70 | 22817900 | |
| 22 | Phosphorylation | PESRHSFTPPLLKKN CCCCCCCCHHHHHCC | 27.32 | 22817900 | |
| 197 | Phosphorylation | GKTLQCVTLVWTLLR CHHHHHHHHHHHHHH | 24.18 | 22668510 | |
| 201 | Phosphorylation | QCVTLVWTLLRQGPE HHHHHHHHHHHHCCC | 14.40 | 22668510 | |
| 212 | Phosphorylation | QGPECKPTINKAIVV HCCCCCCCCCEEEEE | 23.76 | 22668510 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RAD54_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RAD54_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RAD54_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| YC17_DROME | CG16817 | physical | 15710747 | |
| DRICE_DROME | Ice | physical | 15710747 | |
| UBCD2_DROME | UbcD2 | physical | 15710747 | |
| ATR_DROME | mei-41 | genetic | 10559962 | |
| LOK_DROME | lok | genetic | 12361566 | |
| BRCA2_DROME | Brca2 | genetic | 18266476 | |
| BLM_DROME | Blm | genetic | 10454573 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20 AND THR-22, AND MASSSPECTROMETRY. | |
