ASB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASB1_HUMAN
• UniProt AC: Q9Y576
• Protein Name: Ankyrin repeat and SOCS box protein 1
• Gene Name: ASB1
• Organism: Homo sapiens (Human).
• Sequence Length: 335
• Protein Description: May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins..
• Protein Sequence: MAEGGSPDGRAGPGSAGRNLKEWLREQFCDHPLEHCEDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGRRKVDPEALQVFKEARSVPRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEGGSPDG ------CCCCCCCCC	24.92	-
6	Phosphorylation	--MAEGGSPDGRAGP --CCCCCCCCCCCCC	30.58	22199227
15	Phosphorylation	DGRAGPGSAGRNLKE CCCCCCCHHHHCHHH	30.59	26074081
21	Ubiquitination	GSAGRNLKEWLREQF CHHHHCHHHHHHHHH	50.85	-
46	Phosphorylation	TRLHDAAYVGDLQTL CCCCCCCHHHCHHHH	13.49	27642862
55	Phosphorylation	GDLQTLRSLLQEESY HCHHHHHHHHCHHHH	36.22	-
69	Ubiquitination	YRSRINEKSVWCCGW HHHHCCCCCEEECCE	45.91	-
161	Ubiquitination	VGRADILKALIRYGA CCHHHHHHHHHHHCC	41.29	-
280	Ubiquitination	PESRGRRKVDPEALQ CCCCCCCCCCHHHHH	50.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASB1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL5_HUMAN	CUL5	physical	16325183
RBX2_HUMAN	RNF7	physical	16325183
CUL5_HUMAN	CUL5	physical	18187417
ELOB_HUMAN	TCEB2	physical	18187417
ELOC_HUMAN	TCEB1	physical	18187417
CUL5_HUMAN	CUL5	physical	24337577
ELOB_HUMAN	TCEB2	physical	24337577
SSBP_HUMAN	SSBP1	physical	24337577
HCD2_HUMAN	HSD17B10	physical	24337577
HMGB1_HUMAN	HMGB1	physical	24337577
BASI_HUMAN	BSG	physical	24337577
CAND1_HUMAN	CAND1	physical	24337577
AT2A2_HUMAN	ATP2A2	physical	24337577
PTPS_HUMAN	PTS	physical	24337577
ELOC_HUMAN	TCEB1	physical	24337577
MRRP1_HUMAN	TRMT10C	physical	24337577
CPSM_HUMAN	CPS1	physical	24337577
SSRD_HUMAN	SSR4	physical	24337577
U5S1_HUMAN	EFTUD2	physical	24337577
ARL1_HUMAN	ARL1	physical	24337577
SMD1_HUMAN	SNRPD1	physical	24337577
PROF1_HUMAN	PFN1	physical	24337577

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330