ASB10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASB10_HUMAN
• UniProt AC: Q8WXI3
• Protein Name: Ankyrin repeat and SOCS box protein 10
• Gene Name: ASB10
• Organism: Homo sapiens (Human).
• Sequence Length: 467
• Subcellular Localization: Cytoplasm . Nucleus . In the ciliary body, it is detected in the cytoplasm and perinuclear region of the pigmented ciliary epithelial layer. In the retina, it is detected in the nuclei of retinal ganglion cells.
• Protein Description: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins..
• Protein Sequence: MLMSWSPEECKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MLMSWSPEECK ----CCCCCCHHHHC	22.05	24719451
6	Phosphorylation	--MLMSWSPEECKGQ --CCCCCCHHHHCCC	18.35	30177828
30	Acetylation	LCARLVEKPSRGSEE HHHHHHCCCCCCCHH	40.59	7663077
70 (in isoform 3)	Phosphorylation	-	3.38	27050516
144	Phosphorylation	RRRARPDSAPGGRTA HHHCCCCCCCCCHHH	38.76	27542207
150	Phosphorylation	DSAPGGRTALHEACA CCCCCCHHHHHHHHH	36.52	27542207
161	Phosphorylation	EACAAGHTACVHVLL HHHHHCCCCEEEEEE	22.34	27542207
440	Phosphorylation	LRSHLEGSLPQALPR HHHHHCCCCCCCCCC	27.74	30243723
457	Phosphorylation	LPPRLLRYLQLDFEG CCHHHHHHHCCCCCC	9.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASB10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASB10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASB10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSA4_HUMAN	PSMA4	physical	23901248
RM23_HUMAN	MRPL23	physical	21988832
KDM1A_HUMAN	KDM1A	physical	23455924
CUL5_HUMAN	CUL5	physical	24337577
RBX2_HUMAN	RNF7	physical	24337577
CHIP_HUMAN	STUB1	physical	24337577
AP1G1_HUMAN	AP1G1	physical	24337577
ELOB_HUMAN	TCEB2	physical	24337577
ELOC_HUMAN	TCEB1	physical	24337577
EMD_HUMAN	EMD	physical	24337577
PGAM5_HUMAN	PGAM5	physical	24337577
TXTP_HUMAN	SLC25A1	physical	24337577
ADT2_HUMAN	SLC25A5	physical	24337577
EFTU_HUMAN	TUFM	physical	24337577
MPCP_HUMAN	SLC25A3	physical	24337577
CPVL_HUMAN	CPVL	physical	24337577
HSPB1_HUMAN	HSPB1	physical	24337577
ARL1_HUMAN	ARL1	physical	24337577
TBB6_HUMAN	TUBB6	physical	24337577
RL38_HUMAN	RPL38	physical	24337577
UBC_HUMAN	UBC	physical	24337577
RS10_HUMAN	RPS10	physical	24337577
HIF1N_HUMAN	HIF1AN	physical	28514442
P52K_HUMAN	PRKRIR	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.