dbPTM

ARF6_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARF6_DROME
UniProt AC	P40946
Protein Name	ADP-ribosylation factor 6 {ECO:0000305}
Gene Name	Arf51F {ECO:0000312\|FlyBase:FBgn0013750}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	175
Subcellular Localization	Golgi apparatus.
Protein Description	GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). Promotes cell movement and remodeling of the actin cytoskeleton during compound eye morphogenesis. [PubMed: 21976699]
Protein Sequence	MGKLLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARTELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLSEGLIWLTSNHKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
2	Myristoylation	------MGKLLSKIF ------CCHHHHHHH	-
38	Phosphorylation	YKLKLGQSVTTIPTV EEEECCCCEEECCCC	27794539
55	Ubiquitination	NVETVTYKNVKFNVW EEEEEEEECEEEEEE	31113955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ARF6_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ARF6_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARF6_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAHH_DROME	Ahcy13	physical	15710747
DCN1L_DROME	CG7427	physical	15710747
PCNA_DROME	PCNA	physical	15710747
NFS1_DROME	CG12264	physical	15710747
RNH2A_DROME	CG13690	physical	15710747
BRUN_DROME	bru	physical	15710747
APLP_DROME	Rfabg	physical	15710747
RG190_DROME	RhoGAPp190	physical	15710747
RLIP_DROME	Rlip	physical	15710747
AMN_DROME	amn	genetic	23223291

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ARF6_DROME

Related Literatures of Post-Translational Modification