BRUN_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BRUN_DROME
• UniProt AC: Q9VIL0
• Protein Name: Protein brunelleschi {ECO:0000303|PubMed:19934220}
• Gene Name: brun {ECO:0000312|FlyBase:FBgn0261787}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1320
• Subcellular Localization: Cytoplasm . Golgi apparatus . Specific to spermatocytes.
• Protein Description: Cooperates with Rab11 and fwd/PI4K to mediate the flow of membrane through the Golgi, which is required to support cleavage furrow ingression, therefore promoting cytokinesis in male meiotic cells..
• Protein Sequence: MRAAVGLMLSHGAGGMEPALSRPDYEQSALHHSCLLVLLRGVGPSRARVLQRAFEKVRRVNHIRVNDSSGHPRSIWIRFVHDHPVEHNDWGDFQTHRRLLGLVTIGKFDSQIELNELCRQHESLKVRYGSTLYESRAIFFGPDEQPLETIGEVLGPPAAGGRRLQDEFTTPSNFKAQAFFYREQDSCADLESRIGDFASALFWVLESRRLERSREKADKVSLLLAPFEKRDFVGLDMESRNNRKRCVGRVMKNLADLSLQAGLVDDALSLYHNANETLRSVGDSLWVGATEEGLCAASAMLLYPQMRETETLHRNSSLQEAGTSPLKNTPEKWRASDATKKISASDATANNVDSNQPQQRVTSNSSSCSSVSSLVTTATNSSASDTPTTSSSSTSTISAAPIPGHQRNGDLPGNILKAEEISNYYRKAIINYSKYRHAATIETEAALKASRICIEQNRPLDVAMFLQNILYINLSMSEAERVKRFEVITDLYQQIGYQRKAAFFQRLAALKHVQQGSQAPDWNQSYRLMLGSFTGYRLCLDPLEVIENAAGWPALQIDLVQTLITAARRLGHSALATRHMTFLLQTQWDNMSPTEQSEMAVQLQNLSAQCEGSPVPLVLENGTVIPPANLTDLPYCIDLQVKDLPAHLRPQRIKVAKADSGPFLFTPIHFNSVDRRDKKKDKNKIAFQWVQNDLSEVTVRLRNPLPFELPVTDMRLLTNGVVFESLPQTLVLQPHVPTYVALHGTPIETGQLDLQGYSTHTLGVKSNCRLKHMRGRSFPPNYVVDVIPALPRISVKTSLPQTATFSNMNSADIVVTSASLTLYNGESSSCTITITNESATLPLEHLEFSINSNVEQELQQKIFRIDEEAIKAHLPVPPQGTIEIIVDVFAEADFVCPQPPASLHSAAAPGDYGASSLTHYSSVSTSGHASLPSRVGSPHHRRNEPQNSSFRSTISGGPPSLAALTLHPGGGGGVGPSSLGSQYNQHIEAQVRFKYSGGDALTAGYCRQCAVSFNLELLPSVQITSWDVLPAEVASQFYLVLDISNLTAQEMSLNYTDTKNILIEAKESCRVPIPVDRCSLEKVVAARAAEVAENLERELCFRTQLLSFNDALSKLCSIHIAERVKIKWLLTGTDIQGIASLRGIVLSQSMVDLTAVSPLEWAISFQDTLVQPHNEIVCTVGQRSLLSIQLANQSLQPLRNLVLSIKFYQDYLNGMENYNLETRVAISGPNRIAIPLLEKQEQKEHTCSVIFFTPGRFKASIECTSNPQKQSEQPSSLLTRSCPAEAESVGQSVMFSSSYDEQQAHVWKFIPPIEVTVVEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
316	Phosphorylation	TETLHRNSSLQEAGT CCCCCCCCCHHHCCC		19429919
317	Phosphorylation	ETLHRNSSLQEAGTS CCCCCCCCHHHCCCC		19429919
323	Phosphorylation	SSLQEAGTSPLKNTP CCHHHCCCCCCCCCC		25749252
324	Phosphorylation	SLQEAGTSPLKNTPE CHHHCCCCCCCCCCH		25749252
329	Phosphorylation	GTSPLKNTPEKWRAS CCCCCCCCCHHHHCC		25749252
336	Phosphorylation	TPEKWRASDATKKIS CCHHHHCCHHCCCCC		22817900
660	Phosphorylation	IKVAKADSGPFLFTP EEEEECCCCCCCCCC		22817900
666	Phosphorylation	DSGPFLFTPIHFNSV CCCCCCCCCCCCCCC		21082442
672	Phosphorylation	FTPIHFNSVDRRDKK CCCCCCCCCCCCCCC		19429919
937	Phosphorylation	SLPSRVGSPHHRRNE CCCCCCCCCCCCCCC		21082442
1113	Phosphorylation	LSFNDALSKLCSIHI HCHHHHHHHHHHHHH		22668510

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BRUN_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BRUN_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BRUN_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.