ADA30_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADA30_HUMAN
• UniProt AC: Q9UKF2
• Protein Name: Disintegrin and metalloproteinase domain-containing protein 30
• Gene Name: ADAM30
• Organism: Homo sapiens (Human).
• Sequence Length: 790
• Subcellular Localization: Late endosome membrane ; Single-pass type I membrane protein .
• Protein Description: Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation. [PubMed: 27333034]
• Protein Sequence: MRSVQIFLSQCRLLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSPVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMAPYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLNCIMGSGRTGFSNCSYISFFKHISSGATCLNNIPGLGYVLKRCGNKIVEDNEECDCGSTEECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWAPPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLKPKQEKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIESKRPKAKSVKKQKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	VTIPEKLSFRGEVQG EECCHHCEECCEECE	24.78	25554490
112	Phosphorylation	YIPKDCNYMGSVKES CCCCCCCCCCCHHHH	14.80	22985185
222	N-linked_Glycosylation	RYRFVNNNLSQVIHD HHHHHCCCHHHHHHH	35.55	UniProtKB CARBOHYD
251	Acetylation	VRMRIHLKALEVWTD HHHHHHHHHHHHHHC	36.44	7710597
372	N-linked_Glycosylation	SGRTGFSNCSYISFF CCCCCCCCCCHHHHH	19.25	UniProtKB CARBOHYD
438	N-linked_Glycosylation	CKLQPGANCSIGLCC CCCCCCCCCEEEEEE	26.45	UniProtKB CARBOHYD
473	N-linked_Glycosylation	LAEYCDGNSSSCPND HHHHCCCCCCCCCCC	26.01	UniProtKB CARBOHYD
476	Phosphorylation	YCDGNSSSCPNDVYK HCCCCCCCCCCCCCC	33.15	22210691
539	Phosphorylation	QFGNCEITGIRNFKK CCCCCEEECCCCCCC	12.31	24719451
625	N-linked_Glycosylation	CFKKNCVNSSVLQFD EEECCCCCCCEEEEE	30.66	UniProtKB CARBOHYD
685	Phosphorylation	LRGAIPSSIWVVSII HCCCCCHHHHHHHHH	18.34	46159079
746	Phosphorylation	TVQEESKTKTGQEES CHHHHHCCCCCHHHH	43.02	68696175
748	Phosphorylation	QEESKTKTGQEESEA HHHHCCCCCHHHHHH	49.70	30622161
753	Phosphorylation	TKTGQEESEAKTGQE CCCCHHHHHHHHCHH	41.94	30622161
757	Phosphorylation	QEESEAKTGQEESKA HHHHHHHHCHHHHHH	51.66	30622161
777	Phosphorylation	ESKANIESKRPKAKS HHHHHHHHCCCCHHH	30.12	29449344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADA30_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADA30_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADA30_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SC11C_HUMAN	SEC11C	physical	28514442
FOXF2_HUMAN	FOXF2	physical	28514442
SEM6A_HUMAN	SEMA6A	physical	28514442
CALX_HUMAN	CANX	physical	28514442
UBP30_HUMAN	USP30	physical	28514442
MTF2_HUMAN	MTF2	physical	28514442
SPCS2_HUMAN	SPCS2	physical	28514442
ATS2_HUMAN	ADAMTS2	physical	28514442
PLXA2_HUMAN	PLXNA2	physical	28514442
MET7B_HUMAN	METTL7B	physical	28514442
LCLT1_HUMAN	LCLAT1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.