ABHDB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABHDB_HUMAN
• UniProt AC: Q8NFV4
• Protein Name: Protein ABHD11 {ECO:0000305}
• Gene Name: ABHD11 {ECO:0000312|HGNC:HGNC:16407}
• Organism: Homo sapiens (Human).
• Sequence Length: 315
• Protein Sequence: MRAGQQLASMLRWTRAWRLPREGLGPHGPSFARVPVAPSSSSGGRGGAEPRPLPLSYRLLDGEAALPAVVFLHGLFGSKTNFNSIAKILAQQTGRRVLTVDARNHGDSPHSPDMSYEIMSQDLQDLLPQLGLVPCVVVGHSMGGKTAMLLALQRPELVERLIAVDISPVESTGVSHFATYVAAMRAINIADELPRSRARKLADEQLSSVIQDMAVRQHLLTNLVEVDGRFVWRVNLDALTQHLDKILAFPQRQESYLGPTLFLLGGNSQFVHPSHHPEIMRLFPRAQMQTVPNAGHWIHADRPQDFIAAIRGFLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	RAGQQLASMLRWTRA CHHHHHHHHHHHHHH	27.26	46157015
39	Phosphorylation	ARVPVAPSSSSGGRG CCCCCCCCCCCCCCC	32.87	21406692
40	Phosphorylation	RVPVAPSSSSGGRGG CCCCCCCCCCCCCCC	27.71	21406692
41	Phosphorylation	VPVAPSSSSGGRGGA CCCCCCCCCCCCCCC	37.02	21406692
42	Phosphorylation	PVAPSSSSGGRGGAE CCCCCCCCCCCCCCC	47.41	21406692
57	Phosphorylation	PRPLPLSYRLLDGEA CCCCCCEEEECCCCC	16.98	113327985
80 (in isoform 5)	Ubiquitination	-	46.90	21890473
80 (in isoform 4)	Ubiquitination	-	46.90	21890473
80	Ubiquitination	HGLFGSKTNFNSIAK HHHHCCCCCHHHHHH	46.90	19608861
80	Acetylation	HGLFGSKTNFNSIAK HHHHCCCCCHHHHHH	46.90	19608861
80 (in isoform 5)	Acetylation	-	46.90	-
80 (in isoform 4)	Acetylation	-	46.90	-
87 (in isoform 3)	Acetylation	-	36.26	-
87 (in isoform 2)	Acetylation	-	36.26	-
87	Succinylation	TNFNSIAKILAQQTG CCHHHHHHHHHHHHC	36.26	19608861
87	Ubiquitination	TNFNSIAKILAQQTG CCHHHHHHHHHHHHC	36.26	21890473
87 (in isoform 1)	Ubiquitination	-	36.26	21890473
87 (in isoform 2)	Ubiquitination	-	36.26	21890473
87 (in isoform 3)	Ubiquitination	-	36.26	21890473
87	Succinylation	TNFNSIAKILAQQTG CCHHHHHHHHHHHHC	36.26	-
87	Acetylation	TNFNSIAKILAQQTG CCHHHHHHHHHHHHC	36.26	19608861
193 (in isoform 4)	Ubiquitination	-	4.37	21890473
196	Phosphorylation	IADELPRSRARKLAD HHHHCCHHHHHHHHH	28.49	24825855
200	Ubiquitination	LPRSRARKLADEQLS CCHHHHHHHHHHHHH	47.22	2190698
200 (in isoform 1)	Ubiquitination	-	47.22	21890473
221	Phosphorylation	AVRQHLLTNLVEVDG HHHHHHHHHHEEECC	32.63	68730483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABHDB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABHDB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABHDB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
PGM1_HUMAN	PGM1	physical	26344197
NDKM_HUMAN	NME4	physical	27499296
ABHDB_HUMAN	ABHD11	physical	27499296
BOLA3_HUMAN	BOLA3	physical	27499296
DHRS4_HUMAN	DHRS4	physical	27499296
HOGA1_HUMAN	HOGA1	physical	27499296
BOLA1_HUMAN	BOLA1	physical	27499296
ACAD8_HUMAN	ACAD8	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
MIA40_HUMAN	CHCHD4	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-87, AND MASS SPECTROMETRY.
PubMed: 19608861