ZN684_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN684_HUMAN
• UniProt AC: Q5T5D7
• Protein Name: Zinc finger protein 684
• Gene Name: ZNF684
• Organism: Homo sapiens (Human).
• Sequence Length: 378
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MISFQESVTFQDVAVDFTAEEWQLLDCAERTLYWDVMLENYRNLISVGCPITKTKVILKVEQGQEPWMVEGANPHESSPESDYPLVDEPGKHRESKDNFLKSVLLTFNKILTMERIHHYNMSTSLNPMRKKSYKSFEKCLPPNLDLLKYNRSYTVENAYECSECGKAFKKKFHFIRHEKNHTRKKPFECNDCGKAYSRKAHLATHQKIHNGERPFVCNDCGKAFMHKAQLVVHQRLHTGEKPYECSQCGKTFTWNSSFNQHVKSHTLEKSFECKECGKTFRYSSSLYKHSRFHTGEKPYQCIICGKAFGNTSVLVTHQRIHTGEKPYSCIECGKAFIKKSHLLRHQITHTGEKPYECNRCGKAFSQKSNLIVHQKIHT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	O-linked_Glycosylation	ISVGCPITKTKVILK HCCCCCCCCCEEEEE	20.15	30379171
96	Ubiquitination	PGKHRESKDNFLKSV CCCCCCCCCHHHHHH	52.52	-
132	Phosphorylation	LNPMRKKSYKSFEKC CCCCCHHHHHHHHHH	40.61	26657352
133	Phosphorylation	NPMRKKSYKSFEKCL CCCCHHHHHHHHHHC	21.38	26657352
134	Acetylation	PMRKKSYKSFEKCLP CCCHHHHHHHHHHCC	56.62	24886863
135	Phosphorylation	MRKKSYKSFEKCLPP CCHHHHHHHHHHCCC	30.33	26657352
138	Acetylation	KSYKSFEKCLPPNLD HHHHHHHHHCCCCCC	38.78	24886869
238	Phosphorylation	VVHQRLHTGEKPYEC EEECCCCCCCCCEEC	52.18	21857030
282	Phosphorylation	ECGKTFRYSSSLYKH CCCCEEEECCHHHCC	14.55	23836654
283	Phosphorylation	CGKTFRYSSSLYKHS CCCEEEECCHHHCCC	14.81	23836654
284	Phosphorylation	GKTFRYSSSLYKHSR CCEEEECCHHHCCCC	18.54	23836654
285	Phosphorylation	KTFRYSSSLYKHSRF CEEEECCHHHCCCCC	29.76	23836654
287	Phosphorylation	FRYSSSLYKHSRFHT EEECCHHHCCCCCCC	14.49	23836654
322	Phosphorylation	VTHQRIHTGEKPYSC EEECEEECCCCCCCC	44.67	28111955
327	Phosphorylation	IHTGEKPYSCIECGK EECCCCCCCCHHCCC	27.52	-
375	Ubiquitination	SNLIVHQKIHT---- CCEEEEECCCC----	22.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN684_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN684_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN684_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
G3PT_HUMAN	GAPDHS	physical	28514442
POTEE_HUMAN	POTEE	physical	28514442
MTMR4_HUMAN	MTMR4	physical	28514442
RABL6_HUMAN	RABL6	physical	28514442
ASAH1_HUMAN	ASAH1	physical	28514442
AT2L2_HUMAN	PHYKPL	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.