WNT16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WNT16_HUMAN
• UniProt AC: Q9UBV4
• Protein Name: Protein Wnt-16
• Gene Name: WNT16
• Organism: Homo sapiens (Human).
• Sequence Length: 365
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity)..
• Protein Sequence: MDRAALLGLARLCALWAALLVLFPYGAQGNWMWLGIASFGVPEKLGCANLPLNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCMITAAATTAPMGASPLFGYELSSGTKETAFIYAVMAAGLVHSVTRSCSAGNMTECSCDTTLQNGGSASEGWHWGGCSDDVQYGMWFSRKFLDFPIGNTTGKENKVLLAMNLHNNEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMRRREKDQRKIPIHKDDLLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTCK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25 (in isoform 2)	Phosphorylation	-	20.12	22468782
26 (in isoform 2)	Phosphorylation	-	16.20	22468782
50 (in isoform 2)	Phosphorylation	-	2.44	22468782
54	Phosphorylation	CANLPLNSRQKELCK CCCCCCCHHHHHHHH	43.71	29449344
69	Phosphorylation	RKPYLLPSIREGARL CCCCCCHHHHHHHHH	33.96	24719451
114	Phosphorylation	PLFGYELSSGTKETA CCCCEECCCCCCHHH	18.12	23286773
143	N-linked_Glycosylation	TRSCSAGNMTECSCD HCCCCCCCCCEEEEE	33.64	UniProtKB CARBOHYD
189	N-linked_Glycosylation	FLDFPIGNTTGKENK CCCCCCCCCCCCCCE	34.88	UniProtKB CARBOHYD
227	O-palmitoleoylation	DCRCHGVSGSCAVKT CCCCCCCCCCHHHHH	29.58	-
253	Phosphorylation	GHLLKDKYENSIQIS HHHHHHHCCCCCCCC	30.40	-
260	Phosphorylation	YENSIQISDKTKRKM CCCCCCCCHHHHHHH	19.37	19664994
263	Phosphorylation	SIQISDKTKRKMRRR CCCCCHHHHHHHHHH	40.86	19664994
286	Phosphorylation	IHKDDLLYVNKSPNY CCCCCEEEECCCCCC	14.85	24114839
294	S-palmitoylation	VNKSPNYCVEDKKLG ECCCCCCCCCCCCCC	3.25	29575903
299	Ubiquitination	NYCVEDKKLGIPGTQ CCCCCCCCCCCCCCC	65.35	-
310	S-palmitoylation	PGTQGRECNRTSEGA CCCCCCCCCCCCCCC	3.93	29575903
311	N-linked_Glycosylation	GTQGRECNRTSEGAD CCCCCCCCCCCCCCC	45.58	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WNT16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WNT16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
253	Phosphorylation	253 (0)	T ⇒ R;I	rs2707466	Cortical thickness	22792071
260	Phosphorylation	253 (7)	T ⇒ R;I	rs2707466	Cortical thickness	22792071
263	Phosphorylation	253 (10)	T ⇒ R;I	rs2707466	Cortical thickness	22792071

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCBP3_HUMAN	PCBP3	physical	28514442
GALNS_HUMAN	GALNS	physical	28514442
COT2_HUMAN	NR2F2	physical	28514442
CALX_HUMAN	CANX	physical	28514442
WNT5A_HUMAN	WNT5A	physical	28514442
TOR3A_HUMAN	TOR3A	physical	28514442
WLS_HUMAN	WLS	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
N42L2_HUMAN	N4BP2L2	physical	28514442
WNT11_HUMAN	WNT11	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.