WIPI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WIPI1_HUMAN
• UniProt AC: Q5MNZ9
• Protein Name: WD repeat domain phosphoinositide-interacting protein 1
• Gene Name: WIPI1
• Organism: Homo sapiens (Human).
• Sequence Length: 446
• Subcellular Localization: Golgi apparatus, trans-Golgi network. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Preautophagosomal structure membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Trans elements of the Golgi and peripheral endosomes. Dynamicall
• Protein Description: Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway..
• Protein Sequence: MEAEAADAPPGGVESALSCFSFNQDCTSLATGTKAGYKLFSLSSVEQLDQVHGSNEIPDVYIVERLFSSSLVVVVSHTKPRQMNVYHFKKGTEICNYSYSSNILSIRLNRQRLLVCLEESIYIHNIKDMKLLKTLLDIPANPTGLCALSINHSNSYLAYPGSLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTVIRVFSVPDGQKLYEFRRGMKRYVTISSLVFSMDSQFLCASSNTETVHIFKLEQVTNSRPEEPSTWSGYMGKMFMAATNYLPTQVSDMMHQDRAFATARLNFSGQRNICTLSTIQKLPRLLVASSSGHLYMYNLDPQDGGECVLIKTHSLLGSGTTEENKENDLRPSLPQSYAATVARPSASSASTVPGYSEDGGALRGEVIPEHEFATGPVCLDDENEFPPIILCRGNQKGKTKQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	APPGGVESALSCFSF CCCCCHHHHHHHEEE	31.91	22210691
33	Phosphorylation	CTSLATGTKAGYKLF CCHHCCCCCCCEEEE	17.23	22210691
89	Methylation	QMNVYHFKKGTEICN EEEEEEECCCCEECC	36.66	-
90	Methylation	MNVYHFKKGTEICNY EEEEEECCCCEECCE	70.85	-
143	Phosphorylation	LDIPANPTGLCALSI HCCCCCCCCEEEEEC	42.46	-
289	Phosphorylation	MFMAATNYLPTQVSD HHHHHHCCCCCCHHH	15.09	27642862
319	Phosphorylation	SGQRNICTLSTIQKL CCCCCCEEHHHHHHH	21.68	22210691
322	Phosphorylation	RNICTLSTIQKLPRL CCCEEHHHHHHHCCE	30.46	22210691
376	Phosphorylation	KENDLRPSLPQSYAA CCCCCCCCCCHHHHE	46.37	27251275
381	Phosphorylation	RPSLPQSYAATVARP CCCCCHHHHEEECCC	8.60	27642862
389	Phosphorylation	AATVARPSASSASTV HEEECCCCCCCCCCC	34.92	25850435
391	Phosphorylation	TVARPSASSASTVPG EECCCCCCCCCCCCC	30.67	29255136
392	Phosphorylation	VARPSASSASTVPGY ECCCCCCCCCCCCCC	26.42	29255136
394	Phosphorylation	RPSASSASTVPGYSE CCCCCCCCCCCCCCC	31.70	29255136
395	Phosphorylation	PSASSASTVPGYSED CCCCCCCCCCCCCCC	30.36	29255136

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WIPI1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WIPI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WIPI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATG2A_HUMAN	ATG2A	physical	20562859
LEG7_HUMAN	LGALS7	physical	20562859
PKP1_HUMAN	PKP1	physical	20562859
ANDR_HUMAN	AR	physical	15602573
ESR1_HUMAN	ESR1	physical	15602573
RACK1_HUMAN	GNB2L1	physical	26186194
CEP76_HUMAN	CEP76	physical	26186194
S10A7_HUMAN	S100A7	physical	26186194
UHRF1_HUMAN	UHRF1	physical	26186194
UHRF1_HUMAN	UHRF1	physical	28514442
RACK1_HUMAN	GNB2L1	physical	28514442
CEP76_HUMAN	CEP76	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.