TPR2_ARATH - dbPTM
TPR2_ARATH - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TPR2_ARATH
UniProt AC Q9LRZ0
Protein Name Topless-related protein 2
Gene Name TPR2
Organism Arabidopsis thaliana (Mouse-ear cress).
Sequence Length 1131
Subcellular Localization Nucleus.
Protein Description Transcriptional corepressor. Negative regulator of jasmonate responses (By similarity)..
Protein Sequence MSSLSRELVFLILQFLDEEKFKESVHKLEQESGFFFNIKYFEEKALAGEWDEVEKYLSGFTKVDDNRYSMKIFFEIRKQKYLEALDRNDRAKAVEILAKDLKVFATFNEELYKEITQLLTLENFRENEQLSKYGDTKSARSIMYTELKKLIEANPLFREKLAFPSFKASRLRTLINQSLNWQHQLCKNPRPNPDIKTLFLDHSCSPSNGARALTPVNLPVAAVARPSNFVPLGVHGGPFQSNPAPAPNANALAGWMANPNPSSSVPSGVVAASPFPMQPSQVNELKHPRAPSNSLGLMDYQSADHEQLMKRLRSAQTSNEVTYPAHSHPPASLDDLPRNVVSTIRQGSVVISMDFHPSHHTLLAVGCSSGEVTLWEVGSREKVVTEPFKIWNMAACSVIFQGSIVKEPSISVTRVAWSPDGNLLGVSFTKHLIHVYAYQGSDLRQHLEIDAHVGCVNDLAFAHPNKQMCVVTCGDDKLIKVWDLSGKKLFTFEGHEAPVYSICPHQKENIQFIFSTALDGKIKAWLYDNVGSRVDYDAPGQWCTTMLYSADGSRLFSCGTSKEGDSFLVEWNESEGALKRTYLGFRKKSAGVVQFDTTRNRFLAVGEDNQIKFWNMDNTNLLTVVEAEGGLPNLPRLRFNKDGNLLAVTTADNGFKILANTDGLRTLRAFEARSFEASKASIDMKVSTSAMASSISPAIGKIEHMDAGSPARPTPIPNGIEAMSRTMEKPRNLDSVDKSKPLELTEIVDPTQCRQVTMPDSKDSVSKVARLLYTNSGVGVLALGSNGVQRLWKWIRNEQNPTGKATASVTPQHWQPNSGLLMANDVPENPEGSVPCIALSKNDSYVMSACGGKVSLFNMMTFKVMTTFMPPPPASTFLAFHPQDNNIIAIGMEDSSIHIYNVRVDEVKTKLKGHQKHITGLAFSTALNILVSSGADAQLFFWTADSWEKKKSSAIQLPPGKAPVGDTRVQFHNDQIQLLVSHETQLAIYDASKMECIHKWVPQEALSSPITSASYSCNSQLVYASFADGNIAVFDAESLRLRCRIAPSAYMPQPTPNSAPIFPQVITAHPQEPNQLAVGLSDGSVKVIEPSELSRRWGVGVAAGSDKAGTENGRPSSSSAANNSSSDQIQR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
133PhosphorylationENEQLSKYGDTKSAR
HHHHHHHHCCCHHHH		19.5019880383
205PhosphorylationLFLDHSCSPSNGARA
EEECCCCCCCCCCCC		34.0825561503
214PhosphorylationSNGARALTPVNLPVA
CCCCCCCCCCCCCEE		24.9819376835
292PhosphorylationLKHPRAPSNSLGLMD
CCCCCCCCCCCCCCC		37.7623328941
342PhosphorylationDLPRNVVSTIRQGSV
HCCCCHHHHHHCCCE		17.5223328941
681PhosphorylationSFEASKASIDMKVST
CHHHHHCEEEEEECH		23.9025561503
709PhosphorylationIEHMDAGSPARPTPI
CEECCCCCCCCCCCC		19.6730291188
714PhosphorylationAGSPARPTPIPNGIE
CCCCCCCCCCCCHHH		28.4423776212
724PhosphorylationPNGIEAMSRTMEKPR
CCHHHHHHHHCCCCC		31.4823776212
1105PhosphorylationGVGVAAGSDKAGTEN
CCEEECCCCCCCCCC		31.0719880383
1110PhosphorylationAGSDKAGTENGRPSS
CCCCCCCCCCCCCCC		31.0123776212
1116PhosphorylationGTENGRPSSSSAANN
CCCCCCCCCCCCCCC		41.3023776212
1117PhosphorylationTENGRPSSSSAANNS
CCCCCCCCCCCCCCC		30.8723776212
1118PhosphorylationENGRPSSSSAANNSS
CCCCCCCCCCCCCCC		28.4723776212
1119PhosphorylationNGRPSSSSAANNSSS
CCCCCCCCCCCCCCC		33.0923776212
1124PhosphorylationSSSAANNSSSDQIQR
CCCCCCCCCCCCCCC		30.9023776212
1125PhosphorylationSSAANNSSSDQIQR-
CCCCCCCCCCCCCC-		39.8023776212
1126PhosphorylationSAANNSSSDQIQR--
CCCCCCCCCCCCC--		33.1023776212
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TPR2_ARATH !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TPR2_ARATH !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TPR2_ARATH !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HS902_ARATHHSP81-2physical
20856808
LBD41_ARATHLBD41physical
22065421
LBD37_ARATHLBD37physical
22065421
RVE7_ARATHEPR1physical
22065421
RAVL1_ARATHTEM1physical
22065421
HSFB1_ARATHHSF4physical
22065421
IAA8_ARATHIAA8physical
22065421
TCP8_ARATHAT1G58100physical
22065421
CHR4_ARATHCHR4physical
22065421
RH13_ARATHAT3G16840physical
22065421
RAP27_ARATHRAP2.7physical
22065421
IAA10_ARATHIAA10physical
22065421
IAA2_ARATHIAA2physical
22065421
ARFQ_ARATHARF17physical
22065421
TOE2_ARATHTOE2physical
22065421
IAA1_ARATHIAA1physical
22065421
IAA11_ARATHIAA11physical
22065421
AS1_ARATHAS1physical
22065421
BZIP9_ARATHBZIP9physical
22065421
RAV1_ARATHRAV1physical
22065421
SPL1_ARATHSPL1physical
22065421
AP2_ARATHAP2physical
22065421
IAA19_ARATHIAA19physical
22065421
HFB2B_ARATHAT-HSFB2Bphysical
22065421
RAVL3_ARATHAT1G51120physical
22065421
TCP4_ARATHTCP4physical
22065421
SOC1_ARATHAGL20physical
22065421
IAA13_ARATHIAA13physical
22065421
AGL15_ARATHAGL15physical
22065421
RVE1_ARATHRVE1physical
22065421
ZFP4_ARATHZFP4physical
22065421
IAA3_ARATHSHY2physical
22065421
IAA4_ARATHATAUX2-11physical
22065421
GAT16_ARATHGATA16physical
22065421
RAVL2_ARATHAT1G50680physical
22065421
TGA5_ARATHOBF5physical
22065421
WRKY6_ARATHWRKY6physical
22065421
AI5L1_ARATHDPBF2physical
22065421
BZR1_ARATHBZR1physical
24938363
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TPR2_ARATH

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-214 AND SER-709, ANDMASS SPECTROMETRY.

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