| UniProt ID | TM109_MOUSE | |
|---|---|---|
| UniProt AC | Q3UBX0 | |
| Protein Name | Transmembrane protein 109 | |
| Gene Name | Tmem109 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 243 | |
| Subcellular Localization |
Nucleus outer membrane Multi-pass membrane protein . Endoplasmic reticulum membrane Multi-pass membrane protein . Sarcoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. [PubMed: 20060811 Can form voltage-gated calcium and potassium channels in vitro (By similarity] | |
| Protein Sequence | MAGAHSTPLWSRHLLKAVLMVLVALFLVHSASAQSHREFASPGQQKKETSADILTQIGRSLKEMLDTWLGPETMHVISETLLQVMWAISSAISVACFALSGIAAQLLSALGLDGEQLTQGLKLSPSQVQTLLLWGAAALVIYWLLSLLLGLVLALLGRILGGLKLVLFVAGFVALVRSVPDPSTRALMLLALLTLFALLSRLTGSRSSGSHLEAKVRGLERQIEELRGRQRRAAKMPRSMEEE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 41 | Phosphorylation | QSHREFASPGQQKKE HHHHHHCCCCCCCCH | 34.58 | 28464351 | |
| 46 | Acetylation | FASPGQQKKETSADI HCCCCCCCCHHHHHH | 44.69 | 19846437 | |
| 49 | Phosphorylation | PGQQKKETSADILTQ CCCCCCHHHHHHHHH | 37.79 | 28542873 | |
| 50 | Phosphorylation | GQQKKETSADILTQI CCCCCHHHHHHHHHH | 25.65 | 28464351 | |
| 215 | Ubiquitination | SGSHLEAKVRGLERQ CCCHHHHHHHHHHHH | 24.08 | 22790023 | |
| 239 | Phosphorylation | RAAKMPRSMEEE--- HHHHCCCCCCCC--- | 25.36 | 26060331 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TM109_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TM109_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TM109_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PHB_HUMAN | PHB | physical | 26496610 | |
| ROBO2_HUMAN | ROBO2 | physical | 26496610 | |
| RPN2_HUMAN | RPN2 | physical | 26496610 | |
| VDAC1_HUMAN | VDAC1 | physical | 26496610 | |
| VDAC2_HUMAN | VDAC2 | physical | 26496610 | |
| UBP11_HUMAN | USP11 | physical | 26496610 | |
| EXO1_HUMAN | EXO1 | physical | 26496610 | |
| BAP31_HUMAN | BCAP31 | physical | 26496610 | |
| PHB2_HUMAN | PHB2 | physical | 26496610 | |
| GOT1B_HUMAN | GOLT1B | physical | 26496610 | |
| RMND1_HUMAN | RMND1 | physical | 26496610 | |
| ASXL2_HUMAN | ASXL2 | physical | 26496610 | |
| TMM43_HUMAN | TMEM43 | physical | 26496610 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
