SUB_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SUB_ARATH
• UniProt AC: Q8RWZ1
• Protein Name: Protein STRUBBELIG
• Gene Name: SUB
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 768
• Subcellular Localization: Cell membrane ; Single-pass membrane protein .
• Protein Description: Regulates the expression of transcription factors that define the cell fates. Acts in a non-cell-autonomous fashion, functions in a radial inside-out signaling process, and mediates cell morphogenesis and cell fate across clonally distinct cell layers in floral primordia, developing ovules, and root meristems. Seems to be required for the regulation of cell shape and the orientation of the mitotic division plane. Involved in root hair specification, in the formation of the outer integument and the shape of organs such as carpels and petals and is necessary for the shape and height of the stem. Non-functional SUB proteins are retained in the endoplasmic reticulum and degraded by endoplasmic reticulum-associated degradation (ERAD)..
• Protein Sequence: MSFTRWEVFFGLSVLALTMPFSAGVTNLRDVSAINNLYITLGAPSLHHWLAFGGDPCGEKWQGVVCDSSNITEIRIPGMKVGGGLSDTLADFSSIQVMDFSSNHISGTIPQALPSSIRNLSLSSNRFTGNIPFTLSFLSDLSELSLGSNLLSGEIPDYFQQLSKLTKLDLSSNILEGHLPSSMGDLASLKILYLQDNKLTGTLDVIEDLFLTDLNVENNLFSGPIPPNLLKIPNFKKDGTPFNTSIITPPPPPVVDPPPATHRAPPVPRIPPVSGVPPAPFAPFAPLQPQQHPPPSPPLVWSPPSSDNGGGDPWNSVSGQPTLQISPPSGSGSGKFWSTQRIILVVSSVAIIVLVSGLCVTLWRCCRSKIYNRYYSGARKDLQRPYFNKPPSQPTPTMGKVSREPMVKPFDGYGAGDRKYGYPMPQRAEESRRAMPPTSYYNKDVNTPQKPLQQPPRQFQSNDTASKRAAHFPPGLNSSSSATVFTIASLQQYTNNFSEENIIGEGSIGNVYRAELRHGKFLAVKKLSNTINRTQSDGEFLNLVSNVLKLKRGHILELLGYCNEFGQRLLVYEYCPNGSLQDALHLDRKLHKKLTWNVRINIALGASKALQFLHEVCQPPVVHQNFKSSKVLLDGKLSVRVADSGLAYMLPPRPTSQMAGYAAPEVEYGSYTCQSDVFSLGVVMLELLTGRRPFDRTRPRGHQTLAQWAIPRLHDIDALTRMVDPSLHGAYPMKSLSRFADIISRSLQMEPGFRPPISEIVQDLQHMI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	N-linked_Glycosylation	GVVCDSSNITEIRIP EEEECCCCCEEEECC	49.50	-
119	N-linked_Glycosylation	ALPSSIRNLSLSSNR HCCHHHHHEECCCCC	32.10	-
243	N-linked_Glycosylation	KKDGTPFNTSIITPP CCCCCCCCCCCCCCC	33.83	-
447	Phosphorylation	YYNKDVNTPQKPLQQ HCCCCCCCCCCCCCC	27.26	30291188
466	Phosphorylation	FQSNDTASKRAAHFP CCCCCHHHHHHHCCC	25.43	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SUB_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SUB_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SUB_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTBP_ARATH	AN	physical	23368817
Y3288_ARATH	AT3G02880	physical	21423366
Y5838_ARATH	BIR1	physical	21423366
SUB_ARATH	SUB	physical	21423366
Y5639_ARATH	AT5G63930	physical	21423366
MLO2_ARATH	MLO2	physical	21423366
Y5129_ARATH	AT5G10290	physical	21423366
Y5410_ARATH	AT5G24100	physical	21423366
Y3804_ARATH	AT3G28040	physical	21423366
HRD3A_ARATH	AT1G18260	physical	25251695
OS9_ARATH	AT5G35080	physical	25251695

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.