HRD3A_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HRD3A_ARATH
• UniProt AC: Q9LM25
• Protein Name: ERAD-associated E3 ubiquitin-protein ligase component HRD3A {ECO:0000305}
• Gene Name: HRD3A {ECO:0000305}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 678
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass membrane protein .
• Protein Description: Component of the endoplasmic reticulum (ER) quality control system called ER-associated degradation (ERAD) and involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Functions as an ERAD substrate-recruiting factor that recognizes misfolded proteins for the HRD1 E3 ubiquitin ligase complex. Targets the misfolded LRR receptor kinase BRI1..
• Protein Sequence: MRILSYGIVILSLLVFSFIEFGVHARPVVLVLSNDDLNSGGDDNGVGESSDFDEFGESEPKSEEELDPGSWRSIFEPDDSTVQAASPQYYSGLKKILSAASEGNFRLMEEAVDEIEAASSAGDPHAQSIMGFVYGIGMMREKSKSKSFLHHNFAAAGGNMQSKMALAFTYLRQDMHDKAVQLYAELAETAVNSFLISKDSPVVEPTRIHSGTEENKGALRKSRGEEDEDFQILEYQAQKGNANAMYKIGLFYYFGLRGLRRDHTKALHWFLKAVDKGEPRSMELLGEIYARGAGVERNYTKALEWLTLAAKEGLYSAFNGIGYLYVKGYGVDKKNYTKAREYFEKAVDNEDPSGHYNLGVLYLKGIGVNRDVRQATKYFFVAANAGQPKAFYQLAKMFHTGVGLKKNLEMATSFYKLVAERGPWSSLSRWALEAYLKGDVGKALILYSRMAEMGYEVAQSNAAWILDKYGERSMCMGVSGFCTDKERHERAHSLWWRASEQGNEHAALLIGDAYYYGRGTERDFVRAAEAYMHAKSQSNAQAMFNLGYMHEHGQGLPFDLHLAKRYYDESLQSDAAARLPVTLALASLWLRRNYADTVLVRVVDSLPEVYPKVETWIENVVFEEGNATILTLFVCLITILYLRERQRRQVVVVADPVAADVAQPLDADVAQHLAAFPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
298	N-linked_Glycosylation	RGAGVERNYTKALEW HCCCCCCCHHHHHHH		-
335	N-linked_Glycosylation	GYGVDKKNYTKAREY ECCCCCCCHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HRD3A_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HRD3A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HRD3A_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OS9_ARATH	AT5G35080	physical	22328055

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.