dbPTM

OS9_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	OS9_ARATH
UniProt AC	Q8GWH3
Protein Name	Protein OS-9 homolog {ECO:0000305}
Gene Name	OS9 {ECO:0000303\|PubMed:22516478}
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	282
Subcellular Localization	Endoplasmic reticulum .
Protein Description	Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Targets the misfolded LRR receptor kinase BRI1 and the misfolded receptor-like kinase EFR..
Protein Sequence	MRITQILLCLVIVALSSSSHVWSDQIFPAHLVGTFSRNNREPKYKIEFLPEDSPFHPGDNLESMVMLDKHGNRFLCYLPKEEKATSGWTSSQQNISTVMMETQQLVKLKTPDELLQPLSEKCLFRQEGWWSYEFCHQKYVRQLHVEDENKIVQEFFLGTFDPEATAAFNQTVSDASTDASQRYHSHVYTNGTTCDLTGSPREVEVRFVCAETRAMVTSITELSTCKYALTVQCPTLCKHPLFQLEKPVSHTIHCNAIPVEEDATRNKEEQAVDESPKMIADS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
94	N-linked_Glycosylation	GWTSSQQNISTVMME CCCCCCHHHHHHCHH	-
169	N-linked_Glycosylation	PEATAAFNQTVSDAS HHHHHHHCCCCCCCC	-
190	N-linked_Glycosylation	YHSHVYTNGTTCDLT HHCEEECCCCEEECC	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of OS9_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of OS9_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of OS9_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
BRI1_ARATH	BRI1	physical	22328055
HRD3A_ARATH	AT1G18260	physical	22516478

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of OS9_ARATH

Related Literatures of Post-Translational Modification