CTBP_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTBP_ARATH
• UniProt AC: O23702
• Protein Name: C-terminal binding protein AN
• Gene Name: AN
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 636
• Subcellular Localization: Cytoplasm . Golgi apparatus, trans-Golgi network . Was thought initially to be located in nucleus (PubMed:11889033 and PubMed:11889034) but the large dot-like structures are now believed to represent non-physiological aggregates.
• Protein Description: Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex (By similarity). Required for cortical microtubules (MTs) arrangement that confers cell shape. Regulates the width of leaves by controlling the polar elongation of leaf cells. Involved in the regulation of trichome branching. Seems to not be able to regulate gene transcription. Regulates epidermal cell divisions and elongation in a non-cell-autonomous manner (regulated by subepidermal cells), but regulates epidermal cell polarity, shape, trichome branching and elongation in a cell-autonomous manner. Negatively regulates growth in the petiole elongation. Prevents lipid peroxidation as a result of abiotic stress response. Is involved in the SUB-dependent signaling mechanism and may act in a membrane trafficking event around the trans-Golgi network..
• Protein Sequence: MSKIRSSATMPHRDQPSPASPHVVTLNCIEDCALEQDSLAGVAGVEYVPLSRIADGKIESATAVLLHSLAYLPRAAQRRLRPHQLILCLGSADRAVDSTLAADLGLRLVHVDTSRAEEIADTVMALILGLLRRTHLLSRHALSASGWLGSLQPLCRGMRRCRGMVLGIVGRSVSARYLASRSLAFKMSVLYFDVPEGDEERIRPSRFPRAARRMDTLNDLLAASDVISLHCALTNDTVQILNAECLQHIKPGAFLVNTGSCQLLDDCAVKQLLIDGTIAGCALDGAEGPQWMEAWVKEMPNVLILPRSADYSEEVWMEIREKAISILHSFFLDGVIPSNTVSDEEVEESEASEEEEQSPSKHEKLAIVESTSRQQGESTLTSTEIVRREASELKESLSPGQQHVSQNTAVKPEGRRSRSGKKAKKRHSQQKYMQKTDGSSGLNEESTSRRDDIAMSDTEEVLSSSSRCASPEDSRSRKTPLEVMQESSPNQLVMSSKKFIGKSSELLKDGYVVALYAKDLSGLHVSRQRTKNGGWFLDTLSNVSKRDPAAQFIIAYRNKDTVGLRSFAAGGKLLQINRRMEFVFASHSFDVWESWSLEGSLDECRLVNCRNSSAVLDVRVEILAMVGDDGITRWID

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSKIRSSATMPHR --CCCCCCCCCCCCC	28.00	19880383
7	Phosphorylation	-MSKIRSSATMPHRD -CCCCCCCCCCCCCC	20.22	19880383
20	Phosphorylation	RDQPSPASPHVVTLN CCCCCCCCCCEEEEE	20.94	29654922
372	Phosphorylation	LAIVESTSRQQGEST EEEEEECCCCCCCCC	37.05	25561503
381	Phosphorylation	QQGESTLTSTEIVRR CCCCCCCCHHHHHHH	33.42	19880383
382	Phosphorylation	QGESTLTSTEIVRRE CCCCCCCHHHHHHHH	27.44	19880383
383	Phosphorylation	GESTLTSTEIVRREA CCCCCCHHHHHHHHH	25.21	19880383
391	Phosphorylation	EIVRREASELKESLS HHHHHHHHHHHHHCC	38.41	27643528
396	Phosphorylation	EASELKESLSPGQQH HHHHHHHHCCCCCCC	32.34	27643528
398	Phosphorylation	SELKESLSPGQQHVS HHHHHHCCCCCCCCC	35.94	25368622
405	Phosphorylation	SPGQQHVSQNTAVKP CCCCCCCCCCCCCCC	18.65	27643528
408	Phosphorylation	QQHVSQNTAVKPEGR CCCCCCCCCCCCCCC	25.78	27643528
439	Phosphorylation	YMQKTDGSSGLNEES HHHHCCCCCCCCCCC	24.84	29654922
440	Phosphorylation	MQKTDGSSGLNEEST HHHCCCCCCCCCCCC	53.48	29654922
446	Phosphorylation	SSGLNEESTSRRDDI CCCCCCCCCCCCCCC	26.04	25561503
447	Phosphorylation	SGLNEESTSRRDDIA CCCCCCCCCCCCCCC	29.54	25561503
448	Phosphorylation	GLNEESTSRRDDIAM CCCCCCCCCCCCCCC	34.30	25561503
456	Phosphorylation	RRDDIAMSDTEEVLS CCCCCCCCCHHHHHH	32.15	23776212
458	Phosphorylation	DDIAMSDTEEVLSSS CCCCCCCHHHHHHCC	27.09	23776212
463	Phosphorylation	SDTEEVLSSSSRCAS CCHHHHHHCCCCCCC	33.09	23776212
464	Phosphorylation	DTEEVLSSSSRCASP CHHHHHHCCCCCCCC	28.33	23776212
465	Phosphorylation	TEEVLSSSSRCASPE HHHHHHCCCCCCCCC	20.58	23776212
466	Phosphorylation	EEVLSSSSRCASPED HHHHHCCCCCCCCCC	33.07	23776212
470	Phosphorylation	SSSSRCASPEDSRSR HCCCCCCCCCCCCCC	32.23	23776212
488	Phosphorylation	LEVMQESSPNQLVMS HHHHHHCCCCCEECC	27.41	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CTBP_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CTBP_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTBP_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTBP_ARATH	AN	physical	17972097
CTBP_ARATH	AN	physical	11889033
CTBP_ARATH	AN	physical	21798944
CESA7_ARATH	IRX3	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.