SRC33_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRC33_ARATH
• UniProt AC: Q9SEU4
• Protein Name: Serine/arginine-rich SC35-like splicing factor SCL33
• Gene Name: SCL33
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 287
• Subcellular Localization: Nucleus speckle . Nucleus, nucleoplasm . Cytoplasm . Colocalizes with spliceosome components. Follows a dynamic subcellular location during the cell cycle. Distributed throughout the cell on entry into mitosis, as the nuclear envelope breaks down. In
• Protein Description: Involved in intron recognition and spliceosome assembly. Binds to multiple 5'-GAAG-3' repeats found in its third intron, suggesting autoregulation of alternative splicing. [PubMed: 22913769 May be necessary for accurate splicing of the 3' region of introns.]
• Protein Sequence: MRGRSYTPSPPRGYGRRGRSPSPRGRYGGRSRDLPTSLLVRNLRHDCRQEDLRKSFEQFGPVKDIYLPRDYYTGDPRGFGFVQFMDPADAADAKHHMDGYLLLGRELTVVFAEENRKKPTEMRARERGGGRFRDRRRTPPRYYSRSRSPPPRRGRSRSRSGDYYSPPPRRHHPRSISPREERYDGRRSYSRSPASDGSRGRSLTPVRGKSRSLSPSPRRSISRSPRRSRSPSPKRNRSVSPRRSISRSPRRSRSPRRSRRSYTPEPARSRSQSPHGGQYDEDRSPSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MRGRSYTPSPPR ---CCCCCCCCCCCC		23776212
6	Phosphorylation	--MRGRSYTPSPPRG --CCCCCCCCCCCCC		23776212
7	Phosphorylation	-MRGRSYTPSPPRGY -CCCCCCCCCCCCCC		23776212
9	Phosphorylation	RGRSYTPSPPRGYGR CCCCCCCCCCCCCCC		23776212
14	Phosphorylation	TPSPPRGYGRRGRSP CCCCCCCCCCCCCCC		23776212
20	Phosphorylation	GYGRRGRSPSPRGRY CCCCCCCCCCCCCCC		23776212
22	Phosphorylation	GRRGRSPSPRGRYGG CCCCCCCCCCCCCCC		23776212
31	Phosphorylation	RGRYGGRSRDLPTSL CCCCCCCCCCCCHHH		25561503
144	Phosphorylation	RTPPRYYSRSRSPPP CCCCCCCCCCCCCCC		29654922
146	Phosphorylation	PPRYYSRSRSPPPRR CCCCCCCCCCCCCCC		29654922
148	Phosphorylation	RYYSRSRSPPPRRGR CCCCCCCCCCCCCCC		29654922
156	Phosphorylation	PPPRRGRSRSRSGDY CCCCCCCCCCCCCCC		25561503
158	Phosphorylation	PRRGRSRSRSGDYYS CCCCCCCCCCCCCCC		23111157
160	Phosphorylation	RGRSRSRSGDYYSPP CCCCCCCCCCCCCCC		30291188
163	Phosphorylation	SRSRSGDYYSPPPRR CCCCCCCCCCCCCCC		23111157
164	Phosphorylation	RSRSGDYYSPPPRRH CCCCCCCCCCCCCCC		23111157
165	Phosphorylation	SRSGDYYSPPPRRHH CCCCCCCCCCCCCCC		30291188
175	Phosphorylation	PRRHHPRSISPREER CCCCCCCCCCCCHHH		28011693
177	Phosphorylation	RHHPRSISPREERYD CCCCCCCCCCHHHCC		28011693
188	Phosphorylation	ERYDGRRSYSRSPAS HHCCCCCCCCCCCCC		-
190	Phosphorylation	YDGRRSYSRSPASDG CCCCCCCCCCCCCCC		-
202	Phosphorylation	SDGSRGRSLTPVRGK CCCCCCCCCCCCCCC		19376835
204	Phosphorylation	GSRGRSLTPVRGKSR CCCCCCCCCCCCCCC		19376835
238	Phosphorylation	PSPKRNRSVSPRRSI CCCCCCCCCCCCHHC		-
248	Phosphorylation	PRRSISRSPRRSRSP CCHHCCCCCCCCCCC		-
261	Phosphorylation	SPRRSRRSYTPEPAR CCCCCCCCCCCCCCC		29654922
262	Phosphorylation	PRRSRRSYTPEPARS CCCCCCCCCCCCCCC		19880383
263	Phosphorylation	RRSRRSYTPEPARSR CCCCCCCCCCCCCCC		19880383
269	Phosphorylation	YTPEPARSRSQSPHG CCCCCCCCCCCCCCC		29654922
271	Phosphorylation	PEPARSRSQSPHGGQ CCCCCCCCCCCCCCC		-
284	Phosphorylation	GQYDEDRSPSQ---- CCCCCCCCCCC----		-
286	Phosphorylation	YDEDRSPSQ------ CCCCCCCCC------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRC33_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRC33_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRC33_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRC28_ARATH	SCL28	physical	18674533
SRC30_ARATH	SCL30	physical	18674533
SL30A_ARATH	SCL30A	physical	18674533
SRC33_ARATH	SR33	physical	18674533
RU17_ARATH	U1-70K	physical	10593939
SRC33_ARATH	SR33	physical	10593939
SR45_ARATH	SR45	physical	10593939

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.