SR45_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SR45_ARATH
• UniProt AC: Q9SEE9
• Protein Name: Serine/arginine-rich splicing factor SR45
• Gene Name: SR45
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 414
• Subcellular Localization: Nucleus speckle . Nucleus, nucleoplasm . Colocalizes with spliceosome components. During interphase, present in both nuclear speckles and nucleoplasm. Nucleoplasm-speckle shuttling protein. The intranuclear distribution and mobility depend on the pho
• Protein Description: Involved in 5' and 3' splicing site selection of introns, and may bridge the 5' and 3' components of the spliceosome. Isoform 1 is required during flower petal development and isoform 2 is involved in root growth. Regulates negatively glucose and abscisic acid (ABA) signaling during early seedling development. Involved in the RNA-directed DNA methylation pathway. [PubMed: 22274613]
• Protein Sequence: MAKPSRGRRSPSVSGSSSRSSSRSRSGSSPSRSISRSRSRSRSLSSSSSPSRSVSSGSRSPPRRGKSPAGPARRGRSPPPPPSKGASSPSKKAVQESLVLHVDSLSRNVNEAHLKEIFGNFGEVIHVEIAMDRAVNLPRGHGYVEFKARADAEKAQLYMDGAQIDGKVVKATFTLPPRQKVSSPPKPVSAAPKRDAPKSDNAAADAEKDGGPRRPRETSPQRKTGLSPRRRSPLPRRGLSPRRRSPDSPHRRRPGSPIRRRGDTPPRRRPASPSRGRSPSSPPPRRYRSPPRGSPRRIRGSPVRRRSPLPLRRRSPPPRRLRSPPRRSPIRRRSRSPIRRPGRSRSSSISPRKGRGPAGRRGRSSSYSSSPSPRRIPRKISRSRSPKRPLRGKRSSSNSSSSSSPPPPPPPRKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	SPSVSGSSSRSSSRS CCCCCCCCCCCCCCC		19880383
18	Phosphorylation	PSVSGSSSRSSSRSR CCCCCCCCCCCCCCC		19880383
55	Phosphorylation	SSPSRSVSSGSRSPP CCCCCCCCCCCCCCC		29654922
56	Phosphorylation	SPSRSVSSGSRSPPR CCCCCCCCCCCCCCC		29654922
60	Phosphorylation	SVSSGSRSPPRRGKS CCCCCCCCCCCCCCC		29654922
67	Phosphorylation	SPPRRGKSPAGPARR CCCCCCCCCCCCCCC		23776212
77	Phosphorylation	GPARRGRSPPPPPSK CCCCCCCCCCCCCCC		30291188
83	Phosphorylation	RSPPPPPSKGASSPS CCCCCCCCCCCCCCC		19376835
87	Phosphorylation	PPPSKGASSPSKKAV CCCCCCCCCCCHHHH		19376835
88	Phosphorylation	PPSKGASSPSKKAVQ CCCCCCCCCCHHHHH		19376835
90	Phosphorylation	SKGASSPSKKAVQES CCCCCCCCHHHHHHH		19376835
97	Phosphorylation	SKKAVQESLVLHVDS CHHHHHHHHHHHHHH		19376835
104	Phosphorylation	SLVLHVDSLSRNVNE HHHHHHHHHCCCCCH		19376835
106	Phosphorylation	VLHVDSLSRNVNEAH HHHHHHHCCCCCHHH		19376835
182	Phosphorylation	LPPRQKVSSPPKPVS CCCCCCCCCCCCCCC		23776212
183	Phosphorylation	PPRQKVSSPPKPVSA CCCCCCCCCCCCCCC		19880383
189	Phosphorylation	SSPPKPVSAAPKRDA CCCCCCCCCCCCCCC		23776212
199	Phosphorylation	PKRDAPKSDNAAADA CCCCCCCCCCHHHHH		30291188
224	Phosphorylation	ETSPQRKTGLSPRRR CCCCCCCCCCCCCCC		23776212
225 (in isoform 2)	Phosphorylation	-		23572148
227	Phosphorylation	PQRKTGLSPRRRSPL CCCCCCCCCCCCCCC		23776212
232	Phosphorylation	GLSPRRRSPLPRRGL CCCCCCCCCCCCCCC		23776212
240	Phosphorylation	PLPRRGLSPRRRSPD CCCCCCCCCCCCCCC		19376835
245	Phosphorylation	GLSPRRRSPDSPHRR CCCCCCCCCCCCCCC		23776212
248	Phosphorylation	PRRRSPDSPHRRRPG CCCCCCCCCCCCCCC		23776212
256	Phosphorylation	PHRRRPGSPIRRRGD CCCCCCCCCCCCCCC		19376835
264	Phosphorylation	PIRRRGDTPPRRRPA CCCCCCCCCCCCCCC		23776212
272	Phosphorylation	PPRRRPASPSRGRSP CCCCCCCCCCCCCCC		25561503
274	Phosphorylation	RRRPASPSRGRSPSS CCCCCCCCCCCCCCC		29654922
278	Phosphorylation	ASPSRGRSPSSPPPR CCCCCCCCCCCCCCC		23776212
280	Phosphorylation	PSRGRSPSSPPPRRY CCCCCCCCCCCCCCC		23776212
281	Phosphorylation	SRGRSPSSPPPRRYR CCCCCCCCCCCCCCC		23776212
287	Phosphorylation	SSPPPRRYRSPPRGS CCCCCCCCCCCCCCC		23776212
289	Phosphorylation	PPPRRYRSPPRGSPR CCCCCCCCCCCCCCC		23776212
294	Phosphorylation	YRSPPRGSPRRIRGS CCCCCCCCCCCCCCC		23776212
301	Phosphorylation	SPRRIRGSPVRRRSP CCCCCCCCCCCCCCC		23776212
307	Phosphorylation	GSPVRRRSPLPLRRR CCCCCCCCCCCCCCC		30291188
315	Phosphorylation	PLPLRRRSPPPRRLR CCCCCCCCCCCCCCC		29654922
323	Phosphorylation	PPPRRLRSPPRRSPI CCCCCCCCCCCCCCC		29654922
344	Phosphorylation	PIRRPGRSRSSSISP CCCCCCCCCCCCCCC		25561503
346	Phosphorylation	RRPGRSRSSSISPRK CCCCCCCCCCCCCCC		29654922
347	Phosphorylation	RPGRSRSSSISPRKG CCCCCCCCCCCCCCC		25561503
348	Phosphorylation	PGRSRSSSISPRKGR CCCCCCCCCCCCCCC		25561503
350	Phosphorylation	RSRSSSISPRKGRGP CCCCCCCCCCCCCCC		25561503
404	Phosphorylation	SNSSSSSSPPPPPPP CCCCCCCCCCCCCCC		26658240

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SR45_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SR45_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SR45_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RU17_ARATH	U1-70K	physical	10593939
RU17_ARATH	U1-70K	physical	22563826
U2AFB_ARATH	U2AF35B	physical	22563826
U2AFA_ARATH	ATU2AF35A	physical	22563826
SR34A_ARATH	SRp34a	physical	25763493
SRC33_ARATH	SR33	physical	25763493
SR34_ARATH	SR1	physical	25763493
RSZ21_ARATH	RSZP21	physical	25763493
SR34A_ARATH	SRp34a	physical	24832081
SRC33_ARATH	SR33	physical	24832081
SR34_ARATH	SR1	physical	24832081
RSZ21_ARATH	RSZP21	physical	24832081

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.