| UniProt ID | SNF22_SCHPO | |
|---|---|---|
| UniProt AC | O94421 | |
| Protein Name | SWI/SNF chromatin-remodeling complex subunit snf22 | |
| Gene Name | snf22 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 1680 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Helicase. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.. | |
| Protein Sequence | MFAVQGNQKFPKGLTKDNIQSLYQQWQVMRNQGATEENNPEFAQISSILRMVQRAHYARMQQMRNQSSEFPDAENTNLRKQQDTLPTTGFNNLPEGKAGMQTLPGRPASNGPTPPNPGNGNVGLNNPSYMNSQASPNIMNAPLQRDTSVPPAPSMVHPHTNTNANSNNLKVYANQLSQQNTSNPTYHNAYDMASMMKNGSRMNNSFPPTTPYPPANDTTVNSSLPHSFASPSSTFEQPHTVQSRAPSVDTTSSSHSFSARNIPANVSMQQQMGRRGSIPVNPSTFSASSPPSGSMLASPYNGYQNDAASFAHSKLPSSANPNTPFNSTATVDVGAAGSHFPYPQPSNLDAINAKTYFQSSSNSPAPYVYRNNLPPSATSFQPSSSRSPSVDPNTVKSAQHIPRMSPSPSASALKTQSHVPSAKVPPTSKLNHAQLAMLKSQIVAYNCLNSPNGQVPPAVQQAIFGRVYGASNEVSPSMPFQQNVPQMSSVKKDTPTRDANMRTSKAPYIQNIPNQFQRRAYSATIPVKNESLAKPSVSPMPLQQSTGKTEVAKRAQFPTNVNYSSCVDPRTYVKTPIPFSKFSSSENLSLIPSLLPPSISWDDVFLSSEIAIACSIANRIDFLEKENRPKSVNKKILQQDKSKSMIELRCLRLLEKQRSLRETINSVIPHSDSLAAGNLRLMFRNVKRQTMQEANLVLALAEKQKTEHAMRQKEKLLTHLRSIMLHRKSIVTKVDKQNKAKTQRCKDIINFHAHLEKEEKKRIERSARQRLQALRADDEAAYLQLLDKAKDTRITHLLKQTDQYLENLTRAVRIQQSNIHSGNTSGKGSNSAELEAPISEEDKNLDYFKVAHRIHEEVEQPKIFVGGTLKDYQLKGLEWMLSLYNNNLNGILADEMGLGKTIQTIAFITYLIEKKNQQGPFLIIVPLSTLTNWIMEFEKWAPSVKKIAYKGPPQLRKTLQSQIRSSNFNVLLTTFEYIIKDRPLLSRIKWVHMIIDEGHRIKNTQSKLTSTLSTYYHSQYRLILTGTPLQNNLPELWALLNFVLPKIFNSIKSFDEWFNTPFANTGGQDKIGLNEEEALLIIKRLHKVLRPFLFRRLKKDVEKELPDKVEKVIKCPLSGLQLKLYQQMKKHGMLFVDGEKGKTGIKGLQNTVMQLKKICNHPFIFEDVERAIDPSGTNVDLLWRAAGKFELLDRILPKLFLTGHKTLMFFQMTQIMTIMEDYLRSKNWKYLRLDGSTKSDDRCSLLAQFNDPKSDVYIFMLSTRAGGLGLNLQTADTVIIFDTDWNPHQDLQAQDRAHRIGQTKEVRILRLITEKSIEENILSRAQYKLDLDGKVIQAGKFDNKSTPEEREAFLRSLLEHDGDDDHDLTYGELQDDELNELISRTDEELVLFKKLDKERAATDIYGKGKPLERLLTVNELPDFYKVEVDSFAVQSSSELEDQYLERKRRRRNSISYTELTLDELNTVDDPSSTLMPRKRGRPRKKTNSGSSLSTPLSQESSLARSGRKNTPSYKQKALRRYCMEIFERLYNLQSEDGRFVNGLFLYPPNRKLYPDYYIIIKRPIALGKIKRNIKNDRYGDVGELIADFMLMFNNAYTYNEEHSIVYEDAKLMEKTLKEVIEDLEKNNSLHAYEEEALNEEQASLVFLENSEAELPLDSGIVSAEDDKVITYEDSSSSYSE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 247 | Phosphorylation | TVQSRAPSVDTTSSS CCCCCCCCCCCCCCC | 31.47 | 29996109 | |
| 289 | Phosphorylation | PSTFSASSPPSGSML HHHCCCCCCCCCCCC | 40.31 | 27738172 | |
| 405 | Phosphorylation | AQHIPRMSPSPSASA HHCCCCCCCCCCHHH | 24.41 | 29996109 | |
| 407 | Phosphorylation | HIPRMSPSPSASALK CCCCCCCCCCHHHHH | 24.95 | 29996109 | |
| 536 | Phosphorylation | NESLAKPSVSPMPLQ CCCCCCCCCCCCCCC | 34.22 | 29996109 | |
| 538 | Phosphorylation | SLAKPSVSPMPLQQS CCCCCCCCCCCCCCC | 21.59 | 29996109 | |
| 1435 | Phosphorylation | VDSFAVQSSSELEDQ ECEEEECCCHHHHHH | 29.27 | 21712547 | |
| 1437 | Phosphorylation | SFAVQSSSELEDQYL EEEECCCHHHHHHHH | 51.99 | 21712547 | |
| 1453 | Phosphorylation | RKRRRRNSISYTELT HHHHHHCCCCEEEEC | 15.88 | 25720772 | |
| 1455 | Phosphorylation | RRRRNSISYTELTLD HHHHCCCCEEEECHH | 26.31 | 25720772 | |
| 1456 | Phosphorylation | RRRNSISYTELTLDE HHHCCCCEEEECHHH | 11.54 | 25720772 | |
| 1457 | Phosphorylation | RRNSISYTELTLDEL HHCCCCEEEECHHHH | 20.09 | 25720772 | |
| 1460 | Phosphorylation | SISYTELTLDELNTV CCCEEEECHHHHCCC | 26.40 | 29996109 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SNF22_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SNF22_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SNF22_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SNF22_SCHPO | snf22 | physical | 18622392 | |
| SOL1_SCHPO | sol1 | physical | 18622392 | |
| SNF5_SCHPO | snf5 | physical | 18622392 | |
| SSR1_SCHPO | ssr1 | physical | 18622392 | |
| ARP9_SCHPO | arp9 | physical | 18622392 | |
| SNF59_SCHPO | snf59 | physical | 18622392 | |
| SSR2_SCHPO | ssr2 | physical | 18622392 | |
| ARP42_SCHPO | arp42 | physical | 18622392 | |
| SSR3_SCHPO | ssr3 | physical | 18622392 | |
| SSR4_SCHPO | ssr4 | physical | 18622392 | |
| SNF30_SCHPO | snf30 | physical | 18622392 | |
| TAF14_SCHPO | tfg3 | physical | 18622392 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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