SHC4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHC4_HUMAN
• UniProt AC: Q6S5L8
• Protein Name: SHC-transforming protein 4
• Gene Name: SHC4
• Organism: Homo sapiens (Human).
• Sequence Length: 630
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane. Colocalized with MUSK at the neuromuscular junction..
• Protein Description: Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1..
• Protein Sequence: MRERGQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVGNKGSPQPPHPALAPHLPTEDATLPSQESPTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSGPSSPETSLSRSGTAPPPQQDLVGHRATALTPDSCPLPGPGEPTLRSRQDRHFLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRKPPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEVHIDSHAEEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSKCSSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGNQRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKDNNPALLHSNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MRERGQDSLAGLVLY CCCCCHHCHHHHHHH	16.54	-
15	Phosphorylation	SLAGLVLYVGLFGHP CHHHHHHHHHHHCCC	5.74	-
37	Phosphorylation	YSRFRNESITSLDEG HHHHCCCCCCCCCCC	34.41	29507054
39	Phosphorylation	RFRNESITSLDEGSS HHCCCCCCCCCCCCC	32.30	28348404
40	Phosphorylation	FRNESITSLDEGSSG HCCCCCCCCCCCCCC	31.95	22617229
100	Phosphorylation	MKLANPATLLSLKNF CCCCCHHHHHHHCHH	29.50	24114839
103	Phosphorylation	ANPATLLSLKNFCLG CCHHHHHHHCHHHHC	40.17	24505115
127	Phosphorylation	QESRDPGSSGPSSPE CCCCCCCCCCCCCCC	37.19	25850435
128	Phosphorylation	ESRDPGSSGPSSPET CCCCCCCCCCCCCCC	61.71	25850435
131	Phosphorylation	DPGSSGPSSPETSLS CCCCCCCCCCCCCCC	63.15	25850435
132	Phosphorylation	PGSSGPSSPETSLSR CCCCCCCCCCCCCCC	29.86	29507054
135	Phosphorylation	SGPSSPETSLSRSGT CCCCCCCCCCCCCCC	38.05	25850435
136	Phosphorylation	GPSSPETSLSRSGTA CCCCCCCCCCCCCCC	23.76	25850435
159	Phosphorylation	GHRATALTPDSCPLP CCCCEEECCCCCCCC	23.68	-
196	Phosphorylation	GMNYCVRYMGCVEVL CHHHHHHHHHHHHHH	4.21	26503892
218	Phosphorylation	FGMRTQVTREAISRL CCCCHHHHHHHHHHH	16.99	26503892
374	Phosphorylation	EEREDHEYYNEIPGK HHHCCHHHHHCCCCC	14.26	22817900
375	Phosphorylation	EREDHEYYNEIPGKQ HHCCHHHHHCCCCCC	11.88	22817900
403	Phosphorylation	QATEQMAYCPIQCEK EEECCCCCCCCCEEE	8.07	-
413	Phosphorylation	IQCEKLCYLPGNSKC CCEEEEEECCCCCCC	26.77	-
424	Phosphorylation	NSKCSSVYENCLEQS CCCCCHHHHHHHHHH	11.90	25884760
448	Phosphorylation	GVQSQRDTSLLKHTC CCCCHHHHHHHHCCC	24.38	-
449	Phosphorylation	VQSQRDTSLLKHTCR CCCHHHHHHHHCCCE	35.67	24719451
465	Phosphorylation	DLFDDPCYINTQALQ ECCCCCCEECHHHHH	11.55	28152594
468	Phosphorylation	DDPCYINTQALQSTP CCCCEECHHHHHCCC	12.98	28152594
473	Phosphorylation	INTQALQSTPGSAGN ECHHHHHCCCCCCCC	37.10	-
489	Phosphorylation	RSAQPLGSPWHCGKA CCCCCCCCCCCCCCC	32.28	28555341
505	Phosphorylation	ETVQPGATAQPASSH CCCCCCCCCCCCCCC	31.57	27251275
510	Phosphorylation	GATAQPASSHSLPHI CCCCCCCCCCCCHHH	34.95	27251275
511	Phosphorylation	ATAQPASSHSLPHIK CCCCCCCCCCCHHHH	21.14	27251275
513	Phosphorylation	AQPASSHSLPHIKQQ CCCCCCCCCHHHHHH	45.61	27251275
523	Phosphorylation	HIKQQLWSEECYHGK HHHHHHHCCHHHCCH	31.91	26270265
527	Phosphorylation	QLWSEECYHGKLSRK HHHCCHHHCCHHCHH	19.52	26270265
532	Phosphorylation	ECYHGKLSRKAAESL HHHCCHHCHHHHHHH	34.91	26270265
534	Acetylation	YHGKLSRKAAESLLV HCCHHCHHHHHHHEE	48.88	8082881
538	Phosphorylation	LSRKAAESLLVKDGD HCHHHHHHHEECCCC	23.44	-
542	Acetylation	AAESLLVKDGDFLVR HHHHHEECCCCEEEE	56.83	8082891
569	Acetylation	GLQGGQAKHLLLVDP CCCCCCCEEEEEECC	27.22	8082901
596	Phosphorylation	NVGHLIRYHMDNSLP CHHHHHHHHCCCCCC	8.42	-
601	Phosphorylation	IRYHMDNSLPIISSG HHHHCCCCCCEECCC	31.12	27251275
606	Phosphorylation	DNSLPIISSGSEVSL CCCCCEECCCCCEEC	29.39	-
609	Phosphorylation	LPIISSGSEVSLKQP CCEECCCCCEECCCC	36.45	-
612	Phosphorylation	ISSGSEVSLKQPVRK ECCCCCEECCCCCCC	26.29	-
628	Phosphorylation	NNPALLHSNK----- CCCCCCCCCC-----	46.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
159	T	Phosphorylation	Kinase	ERK2	P28482	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHC4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHC4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EGFR_HUMAN	EGFR	physical	24430869
GRB2_HUMAN	GRB2	physical	24430869
NBEA_HUMAN	NBEA	physical	28514442
GARE1_HUMAN	GAREM	physical	28514442
IKKA_HUMAN	CHUK	physical	28514442
DCAM_HUMAN	AMD1	physical	28514442
SHC3_HUMAN	SHC3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.