| UniProt ID | S45A2_HUMAN | |
|---|---|---|
| UniProt AC | Q9UMX9 | |
| Protein Name | Membrane-associated transporter protein | |
| Gene Name | SLC45A2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 530 | |
| Subcellular Localization |
Melanosome membrane Multi-pass membrane protein . |
|
| Protein Description | Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity).. | |
| Protein Sequence | MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEAPLTEVAKGIPPQQTPQDPPLSSDGMYEYGSIEKVKNGYVNPELAMQGAKNKNHAEQTRRAMTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEFLIYERGVEVGCWGLCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPNVYSTLVLCSLFGVMSSTLYTVPFNLITEYHREEEKERQQAPGGDPDNSVRGKGMDCATLTCMVQLAQILVGGGLGFLVNTAGTVVVVVITASAVALIGCCFVALFVRYVD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 | Phosphorylation | AGRHIYKSLADDGPF HHHHHHHHHCCCCCC | 16.30 | 25850435 | |
| 24 | Phosphorylation | ADDGPFDSVEPPKRP CCCCCCCCCCCCCCC | 28.85 | 27251275 | |
| 105 | Phosphorylation | RWGRRRPYILTLGVM HCCCCCCHHHHHHHH | 13.52 | 25072903 | |
| 108 | Phosphorylation | RRRPYILTLGVMMLV CCCCHHHHHHHHHHH | 16.35 | 25072903 | |
| 120 | Phosphorylation | MLVGMALYLNGATVV HHHHHHHHHCCHHHH | 6.65 | 25072903 | |
| 125 | Phosphorylation | ALYLNGATVVAALIA HHHHCCHHHHHHHHH | 19.53 | 25072903 | |
| 278 | Phosphorylation | IEKVKNGYVNPELAM EEEECCCCCCHHHHH | 13.37 | - | |
| 305 | Phosphorylation | RRAMTLKSLLRALVN HHHHHHHHHHHHHHC | 35.43 | 24719451 | |
| 356 | N-linked_Glycosylation | GDPYSAHNSTEFLIY CCCCCCCCCCEEEEE | 50.79 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of S45A2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of S45A2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of S45A2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| G3PT_HUMAN | GAPDHS | physical | 26186194 | |
| SQOR_HUMAN | SQRDL | physical | 28514442 | |
| UBB_HUMAN | UBB | physical | 28514442 | |
| ATG9A_HUMAN | ATG9A | physical | 28514442 | |
| CYHR1_HUMAN | CYHR1 | physical | 28514442 | |
| MINY1_HUMAN | FAM63A | physical | 28514442 | |
| PCX3_HUMAN | PCNXL3 | physical | 28514442 | |
| AT2B2_HUMAN | ATP2B2 | physical | 28514442 | |
| M1IP1_HUMAN | MID1IP1 | physical | 28514442 | |
| T2EA_HUMAN | GTF2E1 | physical | 28514442 | |
| AMFR_HUMAN | AMFR | physical | 28514442 | |
| CSCL1_HUMAN | TMEM63A | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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