RN123_MOUSE - dbPTM
RN123_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RN123_MOUSE
UniProt AC Q5XPI3
Protein Name E3 ubiquitin-protein ligase RNF123
Gene Name Rnf123
Organism Mus musculus (Mouse).
Sequence Length 1314
Subcellular Localization Cytoplasm .
Protein Description Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle..
Protein Sequence MASKGTGMSFSRKSYRLTSDAEKSRVTGIVQEKLLSDYLYRIFSPPDRGPAAATSRKPLNFHNLPEHVDQLLQVDSEDNESQGQVEGRLGPSTVVLDHTGGFEGLLLVDDDLLGVIGHSNFGTIRSTTCVYKGKWVYEVLISSQGLMQIGWCTINCRFNQEEGVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSLGTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVAGFRPLQDPPFADLVRAQRLLGCFQAVLSVELDPVEGRLVETESSEWQLQGQPTVLLTLAHIFHHFAPLLRKVYLVEAVLMSFLLGVVEKGTPEQAQSVVHQILDLLWLFMEDYEVQDCLKQLMMSLLRLYRFSPIVPDLGLQIHYLRLTMSILRHEKSRKFLLSNVLFDMLRSVVFFYIKSPLRVEEAGLKELIPTTWWPHRSSRESRDGKEAREETTEERQRRRAYERGCQRLKKRIEVVEELQVQILKLLLDNKDDNGGEASRYIFLTKFRKFLQENASGRGNTPVLCPPEYMVCFLHRLVSALRFYWDEYKASNPRASFSEEAYIPPQIFYNGKVDYFDLQRLGGLLSHLRKTLKDDLASKANIVIDPLELQAATMDDLDEDEEPAPSAAQRPMQALAIGGALPLPRPGWLSSPTLGRANRFLSTAAVSLMTPRRLLSTMEKVKVRSLNVEQRTREDIEGSHWNEGLLLGRPPEEPEQPLTENSLLEVLDGTVMMYNLSVHQQLGKMVGVSDDVNEYAMALRDTEDKLRRCPKRRKDILAELTKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYWLLRVCLRTIEHGDRTGSLFAFMPEFYLSVAINSYSALKNYFGPVHSMEELPGYEETLTRLAAILAKHFADPRIVGTDIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQRPWAQTNWILVRLWRGCGFGYRYTRLPHLLKTKPEDANLPSLQKPCPSTLLQQHMADLLRQGSDVAPSFLNSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLLRVLEMTITLVPEIFLDWSRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGLESVDHYPILVAVTGILVRLLVHGPTSETEQATSVLLADPCFQLRSICYLLGQPEPLAPGTTLPAPDRKRFSLQSYTDYISAEELAQVEQMLAHLTAASAQAAAASLPTNEEDLCPICYAHPISAVFQPCGHKSCKACINQHLMNNKDCFFCKATIVSVEDWDKAANTSAMSSAA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MASKGTGMS
------CCCCCCCCC		31.11-
6Phosphorylation--MASKGTGMSFSRK
--CCCCCCCCCCCCC		33.1929895711
9PhosphorylationASKGTGMSFSRKSYR
CCCCCCCCCCCCEEE		22.7829176673
11PhosphorylationKGTGMSFSRKSYRLT
CCCCCCCCCCEEECC		31.3429176673
14PhosphorylationGMSFSRKSYRLTSDA
CCCCCCCEEECCCHH		17.8629899451
16DimethylationSFSRKSYRLTSDAEK
CCCCCEEECCCHHHH		38.28-
16MethylationSFSRKSYRLTSDAEK
CCCCCEEECCCHHHH		38.2854541313
18PhosphorylationSRKSYRLTSDAEKSR
CCCEEECCCHHHHHH		18.6329899451
19PhosphorylationRKSYRLTSDAEKSRV
CCEEECCCHHHHHHH		39.1425338131
33UbiquitinationVTGIVQEKLLSDYLY
HCHHHHHHHHHHHHH		37.3222790023
33 (in isoform 2)Ubiquitination-37.3222790023
180 (in isoform 2)Ubiquitination-40.0222790023
180UbiquitinationYDGNRVRKWNVTTTN
ECCCCEEEEEEEECC		40.0222790023
450 (in isoform 2)Ubiquitination-49.9422790023
450UbiquitinationRVEEAGLKELIPTTW
CHHHHCHHHHCCCCC		49.9422790023
511UbiquitinationQVQILKLLLDNKDDN
HHHHHHHHHCCCCCC		5.5827667366
515 (in isoform 2)Ubiquitination-67.1522790023
515UbiquitinationLKLLLDNKDDNGGEA
HHHHHCCCCCCCCCH		67.1522790023
530 (in isoform 2)Ubiquitination-45.3722790023
530UbiquitinationSRYIFLTKFRKFLQE
HHHHHHHHHHHHHHH		45.3722790023
533 (in isoform 2)Ubiquitination-54.2622790023
533UbiquitinationIFLTKFRKFLQENAS
HHHHHHHHHHHHCCC		54.2622790023
613UbiquitinationGGLLSHLRKTLKDDL
HHHHHHHHHHHHHHH		25.2127667366
617UbiquitinationSHLRKTLKDDLASKA
HHHHHHHHHHHHHHC		55.2022790023
617 (in isoform 2)Ubiquitination-55.2022790023
674PhosphorylationLPRPGWLSSPTLGRA
CCCCCCCCCCCCHHH		27.9723737553
675PhosphorylationPRPGWLSSPTLGRAN
CCCCCCCCCCCHHHH		21.5226824392
677PhosphorylationPGWLSSPTLGRANRF
CCCCCCCCCHHHHHH		43.7423737553
683Asymmetric dimethylargininePTLGRANRFLSTAAV
CCCHHHHHHHHHHHH		32.66-
683MethylationPTLGRANRFLSTAAV
CCCHHHHHHHHHHHH		32.6624129315
694PhosphorylationTAAVSLMTPRRLLST
HHHHHHHCHHHHHHC		20.9521454597
700PhosphorylationMTPRRLLSTMEKVKV
HCHHHHHHCHHHHEE		30.2421454597
701PhosphorylationTPRRLLSTMEKVKVR
CHHHHHHCHHHHEEE		29.3529176673
704 (in isoform 2)Ubiquitination-36.2122790023
704UbiquitinationRLLSTMEKVKVRSLN
HHHHCHHHHEEEECC		36.2122790023
709PhosphorylationMEKVKVRSLNVEQRT
HHHHEEEECCHHHCC		27.5529899451
710 (in isoform 2)Ubiquitination-6.12-
789 (in isoform 2)Ubiquitination-37.3522790023
789UbiquitinationALRDTEDKLRRCPKR
HHHCCHHHHHCCCHH		37.3522790023
795 (in isoform 2)Ubiquitination-69.34-
798UbiquitinationRRCPKRRKDILAELT
HCCCHHHHHHHHHHH		53.8322790023
798 (in isoform 2)Ubiquitination-53.8322790023
804 (in isoform 2)Ubiquitination-6.42-
806 (in isoform 2)Ubiquitination-64.6122790023
806UbiquitinationDILAELTKSQKVFSE
HHHHHHHHHHHHHHH		64.6122790023
808UbiquitinationLAELTKSQKVFSEKL
HHHHHHHHHHHHHHH		47.7027667366
812 (in isoform 2)Ubiquitination-36.49-
812UbiquitinationTKSQKVFSEKLDHLS
HHHHHHHHHHHHHHH		36.4927667366
814 (in isoform 2)Ubiquitination-59.0022790023
814UbiquitinationSQKVFSEKLDHLSRR
HHHHHHHHHHHHHHH		59.0022790023
820 (in isoform 2)Ubiquitination-43.95-
906UbiquitinationRLAAILAKHFADPRI
HHHHHHHHHCCCCCC		35.4922790023
906 (in isoform 2)Ubiquitination-35.4922790023
912 (in isoform 2)Ubiquitination-36.45-
992PhosphorylationRLPHLLKTKPEDANL
CCCHHHCCCCCCCCC		52.3725177544
993UbiquitinationLPHLLKTKPEDANLP
CCHHHCCCCCCCCCC		44.8427667366
995UbiquitinationHLLKTKPEDANLPSL
HHHCCCCCCCCCCCC		71.9027667366
999UbiquitinationTKPEDANLPSLQKPC
CCCCCCCCCCCCCCC		3.0627667366
1004UbiquitinationANLPSLQKPCPSTLL
CCCCCCCCCCHHHHH		54.6122790023
1004 (in isoform 2)Ubiquitination-54.6122790023
1010 (in isoform 2)Ubiquitination-4.82-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RN123_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RN123_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RN123_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBAC1_MOUSEUbac1physical
15531880
CDN1B_MOUSECdkn1bphysical
15531880
ACTG_MOUSEActg1physical
19015242
EF1A1_MOUSEEef1a1physical
19015242
FLNC_MOUSEFlncphysical
19015242
FLNB_MOUSEFlnbphysical
19015242
HS71L_MOUSEHspa1lphysical
19015242
ALBU_MOUSEAlbphysical
19015242
MYH9_MOUSEMyh9physical
19015242
DSG1A_MOUSEDsg1aphysical
19015242
UBP19_MOUSEUsp19physical
19015242
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RN123_MOUSE

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Related Literatures of Post-Translational Modification

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