RB27B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RB27B_HUMAN
• UniProt AC: O00194
• Protein Name: Ras-related protein Rab-27B
• Gene Name: RAB27B
• Organism: Homo sapiens (Human).
• Sequence Length: 218
• Subcellular Localization: Membrane; Lipid-anchor.
• Protein Description: May be involved in targeting uroplakins to urothelial apical membranes..
• Protein Sequence: MTDGDYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYNAQGPNGSSGKAFKVHLQLWDTAGQERFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCENPDIVLIGNKADLPDQREVNERQARELADKYGIPYFETSAATGQNVEKAVETLLDLIMKRMEQCVEKTQIPDTVNGGNSGNLDGEKPPEKKCIC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTDGDYDYL ------CCCCCHHHH	49.00	-
2	Acetylation	------MTDGDYDYL ------CCCCCHHHH	49.00	-
6	Phosphorylation	--MTDGDYDYLIKLL --CCCCCHHHHHHHH	16.41	27642862
8	Phosphorylation	MTDGDYDYLIKLLAL CCCCCHHHHHHHHHH	12.23	27642862
18	Phosphorylation	KLLALGDSGVGKTTF HHHHHCCCCCCCEEE	33.31	28060719
29	Phosphorylation	KTTFLYRYTDNKFNP CEEEEEEECCCCCCC	12.61	29083192
30	Phosphorylation	TTFLYRYTDNKFNPK EEEEEEECCCCCCCC	24.89	29083192
33	Ubiquitination	LYRYTDNKFNPKFIT EEEECCCCCCCCEEE	49.69	33845483
40	Phosphorylation	KFNPKFITTVGIDFR CCCCCEEEEEEEECC	20.68	29083192
41	Phosphorylation	FNPKFITTVGIDFRE CCCCEEEEEEEECCC	16.36	29083192
53	Phosphorylation	FREKRVVYNAQGPNG CCCCEEEEECCCCCC	11.26	25003641
61	Phosphorylation	NAQGPNGSSGKAFKV ECCCCCCCCCCEEEE	42.42	25003641
75	Phosphorylation	VHLQLWDTAGQERFR EEEEEECCCCHHHHH	22.55	28857561
83	Phosphorylation	AGQERFRSLTTAFFR CCHHHHHHHHHHHHH	27.62	28450419
85	Phosphorylation	QERFRSLTTAFFRDA HHHHHHHHHHHHHHH	19.82	23186163
86	Phosphorylation	ERFRSLTTAFFRDAM HHHHHHHHHHHHHHH	27.10	23186163
122	Phosphorylation	SQLQANAYCENPDIV HHHHHHHHCCCCCEE	10.49	27642862
154	Ubiquitination	QARELADKYGIPYFE HHHHHHHHHCCCCEE	39.51	29967540
192	Phosphorylation	MEQCVEKTQIPDTVN HHHHHHHHCCCCCCC	20.44	28270605
197	Phosphorylation	EKTQIPDTVNGGNSG HHHCCCCCCCCCCCC	15.54	28270605
203	Phosphorylation	DTVNGGNSGNLDGEK CCCCCCCCCCCCCCC	32.12	25159151
210	Ubiquitination	SGNLDGEKPPEKKCI CCCCCCCCCCCCCCC	71.98	33845483
216	Geranylgeranylation	EKPPEKKCIC----- CCCCCCCCCC-----	5.94	-
218	Methylation	PPEKKCIC------- CCCCCCCC-------	6.81	-
218	Geranylgeranylation	PPEKKCIC------- CCCCCCCC-------	6.81	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RB27B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RB27B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RB27B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYTL4_HUMAN	SYTL4	physical	11956164
SYTL1_HUMAN	SYTL1	physical	11980908
SYTL2_HUMAN	SYTL2	physical	11980908
MELPH_HUMAN	MLPH	physical	11980908
SYTL5_HUMAN	SYTL5	physical	25416956
SYTL1_HUMAN	SYTL1	physical	28514442
SYTL2_HUMAN	SYTL2	physical	28514442
SYTL4_HUMAN	SYTL4	physical	28514442
SYTL5_HUMAN	SYTL5	physical	28514442
CC186_HUMAN	CCDC186	physical	28514442
SYTL3_HUMAN	SYTL3	physical	28514442
RAE1_HUMAN	CHM	physical	28514442
BDH2_HUMAN	BDH2	physical	28514442
GLCM_HUMAN	GBA	physical	28514442
SCRB2_HUMAN	SCARB2	physical	28514442
RAE2_HUMAN	CHML	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.