| UniProt ID | SYTL3_HUMAN | |
|---|---|---|
| UniProt AC | Q4VX76 | |
| Protein Name | Synaptotagmin-like protein 3 | |
| Gene Name | SYTL3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 610 | |
| Subcellular Localization |
Endomembrane system Peripheral membrane protein. |
|
| Protein Description | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity).. | |
| Protein Sequence | MAQEIDLSALKELEREAILQVLYRDQAVQNTEEERTRKLKTHLQHLRWKGAKNTDWEHKEKCCARCQQVLGFLLHRGAVCRGCSHRVCAQCRVFLRGTHAWKCTVCFEDRNVKIKTGEWFYEERAKKFPTGGKHETVGGQLLQSYQKLSKISVVPPTPPPVSESQCSRSPGRLQEFGQFRGFNKSVENLFLSLATHVKKLSKSQNDMTSEKHLLATGPRQCVGQTERRSQSDTAVNVTTRKVSAPDILKPLNQEDPKCSTNPILKQQNLPSSPAPSTIFSGGFRHGSLISIDSTCTEMGNFDNANVTGEIEFAIHYCFKTHSLEICIKACKNLAYGEEKKKKCNPYVKTYLLPDRSSQGKRKTGVQRNTVDPTFQETLKYQVAPAQLVTRQLQVSVWHLGTLARRVFLGEVIIPLATWDFEDSTTQSFRWHPLRAKAEKYEDSVPQSNGELTVRAKLVLPSRPRKLQEAQEGTDQPSLHGQLCLVVLGAKNLPVRPDGTLNSFVKGCLTLPDQQKLRLKSPVLRKQACPQWKHSFVFSGVTPAQLRQSSLELTVWDQALFGMNDRLLGGTRLGSKGDTAVGGDACSLSKLQWQKVLSSPNLWTDMTLVLH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 145 | Phosphorylation | GGQLLQSYQKLSKIS HHHHHHHHHHHHCCE | 9.19 | 27642862 | |
| 149 | Phosphorylation | LQSYQKLSKISVVPP HHHHHHHHCCEECCC | 34.67 | - | |
| 152 | Phosphorylation | YQKLSKISVVPPTPP HHHHHCCEECCCCCC | 22.31 | - | |
| 157 | Phosphorylation | KISVVPPTPPPVSES CCEECCCCCCCCCHH | 42.21 | 27251275 | |
| 167 | Phosphorylation | PVSESQCSRSPGRLQ CCCHHHHCCCCCHHH | 28.31 | 24719451 | |
| 169 | Phosphorylation | SESQCSRSPGRLQEF CHHHHCCCCCHHHHH | 18.53 | 23898821 | |
| 185 | Phosphorylation | QFRGFNKSVENLFLS CCCCCCHHHHHHHHH | 35.45 | 22617229 | |
| 201 | Phosphorylation | ATHVKKLSKSQNDMT HHHHHHHCCCCCCCC | 38.86 | 27732954 | |
| 203 | Phosphorylation | HVKKLSKSQNDMTSE HHHHHCCCCCCCCCC | 30.73 | 28985074 | |
| 208 | Phosphorylation | SKSQNDMTSEKHLLA CCCCCCCCCCHHHHH | 36.28 | 27732954 | |
| 209 | Phosphorylation | KSQNDMTSEKHLLAT CCCCCCCCCHHHHHC | 37.70 | 27732954 | |
| 225 | Phosphorylation | PRQCVGQTERRSQSD CCCCCCCCCCCCCCC | 26.07 | - | |
| 229 | Phosphorylation | VGQTERRSQSDTAVN CCCCCCCCCCCCEEE | 40.01 | 30108239 | |
| 231 | Phosphorylation | QTERRSQSDTAVNVT CCCCCCCCCCEEEEE | 37.87 | 23401153 | |
| 233 | Phosphorylation | ERRSQSDTAVNVTTR CCCCCCCCEEEEEEC | 37.44 | 30108239 | |
| 238 | Phosphorylation | SDTAVNVTTRKVSAP CCCEEEEEECCCCCC | 18.71 | 23312004 | |
| 239 | Phosphorylation | DTAVNVTTRKVSAPD CCEEEEEECCCCCCH | 24.98 | 23312004 | |
| 243 | Phosphorylation | NVTTRKVSAPDILKP EEEECCCCCCHHCCC | 36.80 | 23401153 | |
| 271 | Phosphorylation | LKQQNLPSSPAPSTI HHHCCCCCCCCCCEE | 52.71 | 27251275 | |
| 272 | Phosphorylation | KQQNLPSSPAPSTIF HHCCCCCCCCCCEEE | 24.12 | 27050516 | |
| 311 (in isoform 2) | Ubiquitination | - | 25.40 | 21906983 | |
| 346 | Phosphorylation | KKKKCNPYVKTYLLP HHHCCCCCCEEEECC | 10.69 | 28270605 | |
| 349 | Phosphorylation | KCNPYVKTYLLPDRS CCCCCCEEEECCCCC | 14.90 | 28270605 | |
| 350 | Phosphorylation | CNPYVKTYLLPDRSS CCCCCEEEECCCCCC | 10.67 | 28270605 | |
| 357 | Phosphorylation | YLLPDRSSQGKRKTG EECCCCCCCCCCCCC | 43.79 | - | |
| 369 | Phosphorylation | KTGVQRNTVDPTFQE CCCCCCCCCCCHHHH | 28.60 | 22210691 | |
| 371 (in isoform 2) | Ubiquitination | - | 34.19 | 21906983 | |
| 377 | Phosphorylation | VDPTFQETLKYQVAP CCCHHHHHHHHCCCH | 20.12 | 22210691 | |
| 379 | Ubiquitination | PTFQETLKYQVAPAQ CHHHHHHHHCCCHHH | 40.85 | 21906983 | |
| 379 (in isoform 1) | Ubiquitination | - | 40.85 | 21906983 | |
| 401 | Phosphorylation | VSVWHLGTLARRVFL HHHHHHHHHHHHHHH | 24.49 | 24043423 | |
| 439 | Ubiquitination | PLRAKAEKYEDSVPQ CHHHHHHHHHCCCCC | 59.82 | 2190698 | |
| 439 (in isoform 1) | Ubiquitination | - | 59.82 | 21906983 | |
| 440 | Phosphorylation | LRAKAEKYEDSVPQS HHHHHHHHHCCCCCC | 19.24 | 25954137 | |
| 443 | Phosphorylation | KAEKYEDSVPQSNGE HHHHHHCCCCCCCCE | 24.61 | 21712546 | |
| 447 | Phosphorylation | YEDSVPQSNGELTVR HHCCCCCCCCEEEEE | 40.51 | 25954137 | |
| 452 | Phosphorylation | PQSNGELTVRAKLVL CCCCCEEEEEEEEEC | 12.02 | 21712546 | |
| 586 | Phosphorylation | AVGGDACSLSKLQWQ CCCCCCCCCCHHHHH | 37.08 | 23312004 | |
| 597 | Phosphorylation | LQWQKVLSSPNLWTD HHHHHHHCCCCCCCC | 46.89 | 27251275 | |
| 598 | Phosphorylation | QWQKVLSSPNLWTDM HHHHHHCCCCCCCCE | 17.41 | 27251275 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SYTL3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SYTL3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SYTL3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RB27A_HUMAN | RAB27A | physical | 11773082 | |
| RAB10_HUMAN | RAB10 | physical | 11773082 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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