| UniProt ID | PRY1_CAEEL | |
|---|---|---|
| UniProt AC | O62090 | |
| Protein Name | Axin-like protein pry-1 | |
| Gene Name | pry-1 {ECO:0000312|EMBL:AAL77082.1, ECO:0000312|WormBase:C37A5.9} | |
| Organism | Caenorhabditis elegans. | |
| Sequence Length | 586 | |
| Subcellular Localization | Cell membrane . Nucleus . Cytoplasm, cell cortex . Subcellular location was measured using a GFP reporter gene. Location of the pry-1:GFP fusion protein ranges from plasma membrane and cytoplasmic dots to diffuse cytoplasmic and nuclear staining. Thi | |
| Protein Description | Works in parallel with axl-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Inhibits Wnt signaling, which affects tissue specific expression of Hox genes, egl-5, lin-39 and mab-5. This in turn affects QR (postembryonic neuroblast) cell migration, vulval cell fate specification, and the development of sensory structures by the seam cell lineage. Has a role in alae V cell patterning, ray formation in the male tail and axon guidance. Does not affect B cell polarity.. | |
| Protein Sequence | METHLGWARSLEAVLSDRSALDAFQEWLIEYSSPQYLDLFFAIRAYERMALEGKPEKSQLSKSIYSKFLSSRTGNCEAIPKHFRAPIGEKLRHGTELEDRVFSHCSNFVQEFLRRQHEEFVGSEEFIEAFNKMSSTTADQLPGGSAHHSSHQNTMRRSSGTTSRKSAAQIATQLTAEALLKSKHDRHSKLGETKLEKMYPPTRQPYVCNATTSHNDSAVSSTFSGDTPEAHRMHSNRLRHIRDEQARENHGTMTLPRVEKASVDGQQWDHSSESGRRNFAMEITRKLLRHIDKVKLNDEMEKRIDDIEECRYTTIDMVNGTEPNDDLGKIDEDEELDDYLKMKMTDDSQKGSTNRSPKGPAGEPNKSGEGSKNTTLSPTNRAPAQLHNTIRVPRRKDYPRDTSASLKSHRHHQIDTNRMMSQSMCAPSYSSASSSYSRDSFAPAPTTRVNFAPGSSKSSQFYDSSGIGSMAPSAFSATSSLDYKDRRQHRKAPTPKKHSKIGKNLSNLITISYLGTDKIPVVTHVPNDGPMTLAEFKRHFALPNGAHQLFFKTECEDGSAPFQLLLIKDEHHLLPVFEGRIAAELR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of PRY1_CAEEL !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRY1_CAEEL !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRY1_CAEEL !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRY1_CAEEL !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| BAR1_CAEEL | bar-1 | genetic | 12023307 | |
| MAB5_CAEEL | mab-5 | genetic | 12023307 | |
| POP1_CAEEL | pop-1 | genetic | 12023307 | |
| DPY30_CAEEL | dpy-30 | genetic | 16845399 | |
| VMA21_CAEEL | pdcd-2 | genetic | 16845399 | |
| H2AV_CAEEL | htz-1 | genetic | 16845399 | |
| HM18_CAEEL | ceh-18 | genetic | 16845399 | |
| GEX3_CAEEL | gex-3 | genetic | 16845399 | |
| KIN20_CAEEL | kin-20 | genetic | 16845399 | |
| LIN59_CAEEL | lin-59 | genetic | 16845399 | |
| TIP60_CAEEL | mys-1 | genetic | 16845399 | |
| YM2A_CAEEL | zfp-1 | genetic | 16845399 | |
| YM2B_CAEEL | zfp-1 | genetic | 16845399 | |
| TMA7_CAEEL | F49C12.11 | genetic | 16845399 | |
| HM32_CAEEL | ceh-32 | genetic | 16845399 | |
| YP62_CAEEL | B0495.2 | genetic | 16845399 | |
| AXLP1_CAEEL | axl-1 | physical | 17601533 | |
| GSK3_CAEEL | gsk-3 | physical | 17601533 | |
| GSK3B_HUMAN | GSK3B | physical | 17601533 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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