PRRT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRRT2_HUMAN
• UniProt AC: Q7Z6L0
• Protein Name: Proline-rich transmembrane protein 2
• Gene Name: PRRT2
• Organism: Homo sapiens (Human).
• Sequence Length: 340
• Subcellular Localization: Cell membrane . Cell junction, synapse, presynaptic cell membrane . Cell junction, synapse . Cell projection, axon . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Cell junction, synapse, postsynaptic cell membrane, postsynaptic densi
• Protein Description: As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation..
• Protein Sequence: MAASSSEISEMKGVEESPKVPGEGPGHSEAETGPPQVLAGVPDQPEAPQPGPNTTAAPVDSGPKAGLAPETTETPAGASETAQATDLSLSPGGESKANCSPEDPCQETVSKPEVSKEATADQGSRLESAAPPEPAPEPAPQPDPRPDSQPTPKPALQPELPTQEDPTPEILSESVGEKQENGAVVPLQAGDGEEGPAPEPHSPPSKKSPPANGAPPRVLQQLVEEDRMRRAHSGHPGSPRGSLSRHPSSQLAGPGVEGGEGTQKPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIASCVINLGVYK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAASSSEISEM ----CCCCHHHHHHH	25.51	24719451
5	Phosphorylation	---MAASSSEISEMK ---CCCCHHHHHHHC	27.54	24719451
28	Phosphorylation	PGEGPGHSEAETGPP CCCCCCCCCCCCCCC	44.40	-
53	N-linked_Glycosylation	EAPQPGPNTTAAPVD CCCCCCCCCCCCCCC	56.85	UniProtKB CARBOHYD
74	Phosphorylation	LAPETTETPAGASET CCCCCCCCCCCCCCC	19.15	-
88	Phosphorylation	TAQATDLSLSPGGES CCCCCCCCCCCCCCC	29.61	24076635
90	Phosphorylation	QATDLSLSPGGESKA CCCCCCCCCCCCCCC	20.37	18510355
95	Phosphorylation	SLSPGGESKANCSPE CCCCCCCCCCCCCCC	40.10	24076635
100	Phosphorylation	GESKANCSPEDPCQE CCCCCCCCCCCCHHC	31.00	24076635
202	Phosphorylation	GPAPEPHSPPSKKSP CCCCCCCCCCCCCCC	49.58	20886841
205	Phosphorylation	PEPHSPPSKKSPPAN CCCCCCCCCCCCCCC	56.98	20886841
208	Phosphorylation	HSPPSKKSPPANGAP CCCCCCCCCCCCCCC	39.59	20886841
233	Phosphorylation	DRMRRAHSGHPGSPR HHHHHHHCCCCCCCC	37.50	-
238	Phosphorylation	AHSGHPGSPRGSLSR HHCCCCCCCCCCCCC	18.84	25332170
240	Methylation	SGHPGSPRGSLSRHP CCCCCCCCCCCCCCC	49.37	-
242	Phosphorylation	HPGSPRGSLSRHPSS CCCCCCCCCCCCCCH	25.17	25332170
244	Phosphorylation	GSPRGSLSRHPSSQL CCCCCCCCCCCCHHC	30.18	25332170
248	Phosphorylation	GSLSRHPSSQLAGPG CCCCCCCCHHCCCCC	25.29	25332170
249	Phosphorylation	SLSRHPSSQLAGPGV CCCCCCCHHCCCCCC	33.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRRT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRRT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRRT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDUV3_HUMAN	NDUFV3	physical	26186194
CALL5_HUMAN	CALML5	physical	26186194
NDUB9_HUMAN	NDUFB9	physical	26186194
NDUB8_HUMAN	NDUFB8	physical	26186194
TBRG4_HUMAN	TBRG4	physical	26186194
NDUS4_HUMAN	NDUFS4	physical	26186194
DDI1_HUMAN	DDI1	physical	26186194
LCLT1_HUMAN	LCLAT1	physical	26186194
NDUS4_HUMAN	NDUFS4	physical	28514442
NDUB8_HUMAN	NDUFB8	physical	28514442
DDI1_HUMAN	DDI1	physical	28514442
NDUB9_HUMAN	NDUFB9	physical	28514442
LCLT1_HUMAN	LCLAT1	physical	28514442
NDUV3_HUMAN	NDUFV3	physical	28514442
TBRG4_HUMAN	TBRG4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 128200: Episodic kinesigenic dyskinesia 1 (EKD1)
• 602066: Convulsions, familial infantile, with paroxysmal choreoathetosis (ICCA)
• 605751: Seizures, benign familial infantile 2 (BFIS2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.