dbPTM

OSTM1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	OSTM1_MOUSE
UniProt AC	Q8BGT0
Protein Name	Osteopetrosis-associated transmembrane protein 1
Gene Name	Ostm1
Organism	Mus musculus (Mouse).
Sequence Length	338
Subcellular Localization	Lysosome membrane Single-pass type I membrane protein . Requires CLCN7 to travel to lysosomes.
Protein Description	Required for osteoclast and melanocyte maturation and function..
Protein Sequence	MARDAELARSSGWPWRWLPALLLLQLLRWRCALCALPFTSSRHPGFADLLSEQQLLEVQDLTLSLLQGGGLGPLSLLPPDLPDLEPECRELLMDFANSSAELTACMVRSARPVRLCQTCYPLFQQVAIKMDNISRNIGNTSEGPRCGGSLLTADRMQIVLMVSEFFNSTWQEANCANCLTNNGEDLSNNTEDFLSLFNKTLACFEHNLQGHTYSLLPPKNYSEVCRNCKEAYKNLSLLYSQMQKLNGLENKAEPETHLCIDVEDAMNITRKLWSRTFNCSVTCSDTVSVVAVSVFILFLPVVFYLSSFLHSEQKKRKLILPKRLKSSTSFANIQENAT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
97	N-linked_Glycosylation	ELLMDFANSSAELTA HHHHHHHCCCHHHHH	36.17	-
118	Phosphorylation	RPVRLCQTCYPLFQQ CHHHHHHHHHHHHHH	17.01	19144319
120	Phosphorylation	VRLCQTCYPLFQQVA HHHHHHHHHHHHHHH	13.32	19144319
132	N-linked_Glycosylation	QVAIKMDNISRNIGN HHHHHHHCCCCCCCC	30.54	-
139	N-linked_Glycosylation	NISRNIGNTSEGPRC CCCCCCCCCCCCCCC	36.31	-
167	N-linked_Glycosylation	LMVSEFFNSTWQEAN HHHHHHHCCCHHHHH	43.80	-
188	N-linked_Glycosylation	NNGEDLSNNTEDFLS CCCCCCCCCHHHHHH	67.74	-
198	N-linked_Glycosylation	EDFLSLFNKTLACFE HHHHHHHHHHHHHHH	41.52	-
220	N-linked_Glycosylation	YSLLPPKNYSEVCRN EECCCCCCHHHHHHH	51.87	-
234	N-linked_Glycosylation	NCKEAYKNLSLLYSQ HHHHHHHHHHHHHHH	23.37	-
267	N-linked_Glycosylation	IDVEDAMNITRKLWS EEHHHHHHHHHHHHH	33.91	-
278	N-linked_Glycosylation	KLWSRTFNCSVTCSD HHHHCCCCCEEECCC	19.28	-
325	Ubiquitination	LILPKRLKSSTSFAN CCCCHHHCCCCCCCH	46.52	27667366
326	Phosphorylation	ILPKRLKSSTSFANI CCCHHHCCCCCCCHH	43.36	25521595
327	Phosphorylation	LPKRLKSSTSFANIQ CCHHHCCCCCCCHHH	26.87	25521595
328	Phosphorylation	PKRLKSSTSFANIQE CHHHCCCCCCCHHHH	34.65	27087446
329	Phosphorylation	KRLKSSTSFANIQEN HHHCCCCCCCHHHHC	25.06	25521595
338	Phosphorylation	ANIQENAT------- CHHHHCCC-------	51.21	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of OSTM1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of OSTM1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of OSTM1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLCN7_MOUSE	Clcn7	physical	16525474
KINH_HUMAN	KIF5B	physical	26598607
DOCK7_HUMAN	DOCK7	physical	26598607
CKAP5_HUMAN	CKAP5	physical	26598607
MTMR3_HUMAN	MTMR3	physical	26598607
ARI3A_HUMAN	ARID3A	physical	26598607
RUVB1_HUMAN	RUVBL1	physical	26598607
ARNT_HUMAN	ARNT	physical	26598607
IMB1_HUMAN	KPNB1	physical	26598607
NU160_HUMAN	NUP160	physical	26598607
LRC41_HUMAN	LRRC41	physical	26598607
TCPA_HUMAN	TCP1	physical	26598607
TCPG_HUMAN	CCT3	physical	26598607
PFKAP_HUMAN	PFKP	physical	26598607
2AAA_HUMAN	PPP2R1A	physical	26598607
UBR5_HUMAN	UBR5	physical	26598607
KCC2A_HUMAN	CAMK2A	physical	26598607
CLCN7_MOUSE	Clcn7	physical	26598607

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of OSTM1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329, AND MASSSPECTROMETRY.	17242355 [Abstract]
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-118 AND TYR-120, ANDMASS SPECTROMETRY.	19144319 [Abstract]