| UniProt ID | CLCN7_MOUSE | |
|---|---|---|
| UniProt AC | O70496 | |
| Protein Name | H(+)/Cl(-) exchange transporter 7 | |
| Gene Name | Clcn7 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 803 | |
| Subcellular Localization |
Lysosome membrane Multi-pass membrane protein . |
|
| Protein Description | Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen.. | |
| Protein Sequence | MANVSKKVSWSGRDRDDEEGAPLLRRTGQPDEETPLLNGAGPGARQSHSALFRIGQMNNVELDDELLDPEVDPPHTFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKDNIDKFTEKGGLSFSLLLWATLNSAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGILGAVFNALNYWLTMFRIRYIHRPCLQVIEAMLVAAVTATVAFVLIYSSRDCQPLQGSSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPMTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGIIVDVLSDTASNHNGFPVVEDVGDTQPARLQGLILRSQLIVLLKHKVFVERSNMGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNHNQVVGLVTRKDLARYRLGKGGLEELSLAQT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | ANVSKKVSWSGRDRD CCCCCCCCCCCCCCC | 25.14 | 23684622 | |
| 11 | Phosphorylation | VSKKVSWSGRDRDDE CCCCCCCCCCCCCCC | 19.22 | 22324799 | |
| 47 | Phosphorylation | AGPGARQSHSALFRI CCCCHHHCHHHHHHH | 17.54 | 27180971 | |
| 49 | Phosphorylation | PGARQSHSALFRIGQ CCHHHCHHHHHHHCC | 31.73 | 27180971 | |
| 79 | Ubiquitination | DPPHTFPKEIPHNEK CCCCCCCCCCCCCHH | 65.17 | 22790023 | |
| 89 | Phosphorylation | PHNEKLLSLKYESLD CCCHHHHHEEEECCC | 33.00 | 24719451 | |
| 92 | Phosphorylation | EKLLSLKYESLDYDN HHHHHEEEECCCCCC | 18.95 | 30635358 | |
| 94 | Phosphorylation | LLSLKYESLDYDNSE HHHEEEECCCCCCCC | 24.37 | 30635358 | |
| 97 | Phosphorylation | LKYESLDYDNSENQL EEEECCCCCCCCCCE | 23.47 | 30635358 | |
| 230 | Phosphorylation | KTLVIKVSGVILSVV CEEEEEECHHHHHHH | 23.49 | - | |
| 235 | Phosphorylation | KVSGVILSVVGGLAV EECHHHHHHHCCCCC | 12.02 | - | |
| 260 | Phosphorylation | SVIAAGISQGRSTSL CEEEEEECCCCCCCC | 26.18 | 21454597 | |
| 276 | Phosphorylation | RDFKIFEYFRRDTEK HHHHHHHHHCCCCCC | 7.52 | - | |
| 799 | Phosphorylation | KGGLEELSLAQT--- CCCHHHHHCCCC--- | 25.57 | 27717184 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CLCN7_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CLCN7_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CLCN7_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| OSTM1_MOUSE | Ostm1 | physical | 16525474 | |
| OSTM1_MOUSE | Ostm1 | physical | 26598607 | |
| KINH_MOUSE | Kif5b | physical | 26598607 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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