O51E2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: O51E2_HUMAN
• UniProt AC: Q9H255
• Protein Name: Olfactory receptor 51E2
• Gene Name: OR51E2
• Organism: Homo sapiens (Human).
• Sequence Length: 320
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Probable G protein-coupled receptor that is activated by the short chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure. [PubMed: 23401498 May also be activated by steroid hormones and regulate cell proliferation]
• Protein Sequence: MSSCNFTHATFVLIGIPGLEKAHFWVGFPLLSMYVVAMFGNCIVVFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREISFEACLTQMFFIHALSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTAQIGIVAVVRGSLFFFPLPLLIKRLAFCHSNVLSHSYCVHQDVMKLAYADTLPNVVYGLTAILLVMGVDVMFISLSYFLIIRTVLQLPSKSERAKAFGTCVSHIGVVLAFYVPLIGLSVVHRFGNSLHPIVRVVMGDIYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDLQAVGGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	N-linked_Glycosylation	---MSSCNFTHATFV ---CCCCCCCCEEEE	46.96	UniProtKB CARBOHYD
53	Phosphorylation	FIVRTERSLHAPMYL EEECCCCCCCHHHHH	20.48	24275569
59	Phosphorylation	RSLHAPMYLFLCMLA CCCCHHHHHHHHHHH	8.01	24275569
73	Phosphorylation	AAIDLALSTSTMPKI HHHHHHHCCCCCHHH	18.07	24275569
75	Phosphorylation	IDLALSTSTMPKILA HHHHHCCCCCHHHHH	21.23	24275569
229	Phosphorylation	RTVLQLPSKSERAKA HHHHCCCCHHHHHHH	58.36	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of O51E2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of O51E2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of O51E2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HPHL1_HUMAN	HEPHL1	physical	26186194
CALL3_HUMAN	CALML3	physical	26186194
S10A3_HUMAN	S100A3	physical	26186194
LRC15_HUMAN	LRRC15	physical	26186194
DSG4_HUMAN	DSG4	physical	26186194
DUS14_HUMAN	DUSP14	physical	26186194
EPCR_HUMAN	PROCR	physical	26186194
LRC15_HUMAN	LRRC15	physical	28514442
DSG4_HUMAN	DSG4	physical	28514442
HPHL1_HUMAN	HEPHL1	physical	28514442
S10A3_HUMAN	S100A3	physical	28514442
DUS14_HUMAN	DUSP14	physical	28514442
FA26D_HUMAN	FAM26D	physical	28514442
CALL3_HUMAN	CALML3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.