| UniProt ID | NRPD1_ARATH | |
|---|---|---|
| UniProt AC | Q9LQ02 | |
| Protein Name | DNA-directed RNA polymerase IV subunit 1 | |
| Gene Name | NRPD1 | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 1453 | |
| Subcellular Localization | Nucleus . Follows a punctate localization pattern. | |
| Protein Description | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Largest and catalytic component of RNA polymerase IV which mediates 24-nt short-interfering RNAs (siRNA) accumulation. Implicated in siRNA-directed heterochromatin formation through the action of DCL3 and AGO4, and subsequent DNA methylation-dependent silencing of targeted sequences. Essential component of a self-reinforcing loop coupling de novo DNA methylation to siRNA production. Required for intercellular but not intracellular RNA interference (RNAi) leading to systemic post-transcriptional gene silencing. Involved in the maintenance of post-transcriptional RNA silencing.. | |
| Protein Sequence | MEDDCEELQVPVGTLTSIGFSISNNNDRDKMSVLEVEAPNQVTDSRLGLPNPDSVCRTCGSKDRKVCEGHFGVINFAYSIINPYFLKEVAALLNKICPGCKYIRKKQFQITEDQPERCRYCTLNTGYPLMKFRVTTKEVFRRSGIVVEVNEESLMKLKKRGVLTLPPDYWSFLPQDSNIDESCLKPTRRIITHAQVYALLLGIDQRLIKKDIPMFNSLGLTSFPVTPNGYRVTEIVHQFNGARLIFDERTRIYKKLVGFEGNTLELSSRVMECMQYSRLFSETVSSSKDSANPYQKKSDTPKLCGLRFMKDVLLGKRSDHTFRTVVVGDPSLKLNEIGIPESIAKRLQVSEHLNQCNKERLVTSFVPTLLDNKEMHVRRGDRLVAIQVNDLQTGDKIFRSLMDGDTVLMNRPPSIHQHSLIAMTVRILPTTSVVSLNPICCLPFRGDFDGDCLHGYVPQSIQAKVELDELVALDKQLINRQNGRNLLSLGQDSLTAAYLVNVEKNCYLNRAQMQQLQMYCPFQLPPPAIIKASPSSTEPQWTGMQLFGMLFPPGFDYTYPLNNVVVSNGELLSFSEGSAWLRDGEGNFIERLLKHDKGKVLDIIYSAQEMLSQWLLMRGLSVSLADLYLSSDLQSRKNLTEEISYGLREAEQVCNKQQLMVESWRDFLAVNGEDKEEDSVSDLARFCYERQKSATLSELAVSAFKDAYRDVQALAYRYGDQSNSFLIMSKAGSKGNIGKLVQHSMCIGLQNSAVSLSFGFPRELTCAAWNDPNSPLRGAKGKDSTTTESYVPYGVIENSFLTGLNPLESFVHSVTSRDSSFSGNADLPGTLSRRLMFFMRDIYAAYDGTVRNSFGNQLVQFTYETDGPVEDITGEALGSLSACALSEAAYSALDQPISLLETSPLLNLKNVLECGSKKGQREQTMSLYLSEYLSKKKHGFEYGSLEIKNHLEKLSFSEIVSTSMIIFSPSSNTKVPLSPWVCHFHISEKVLKRKQLSAESVVSSLNEQYKSRNRELKLDIVDLDIQNTNHCSSDDQAMKDDNVCITVTVVEASKHSVLELDAIRLVLIPFLLDSPVKGDQGIKKVNILWTDRPKAPKRNGNHLAGELYLKVTMYGDRGKRNCWTALLETCLPIMDMIDWGRSHPDNIRQCCSVYGIDAGRSIFVANLESAVSDTGKEILREHLLLVADSLSVTGEFVALNAKGWSKQRQVESTPAPFTQACFSSPSQCFLKAAKEGVRDDLQGSIDALAWGKVPGFGTGDQFEIIISPKVHGFTTPVDVYDLLSSTKTMRRTNSAPKSDKATVQPFGLLHSAFLKDIKVLDGKGIPMSLLRTIFTWKNIELLSQSLKRILHSYEINELLNERDEGLVKMVLQLHPNSVEKIGPGVKGIRVAKSKHGDSCCFEVVRIDGTFEDFSYHKCVLGATKIIAPKKMNFYKSKYLKNGTLESGGFSENP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 143 | Phosphorylation | TKEVFRRSGIVVEVN CHHHHHHCCCEEEEC | 28.72 | 28011693 | |
| 957 | Phosphorylation | HLEKLSFSEIVSTSM HHHHCCHHHHCCCCE | 24.04 | 19880383 | |
| 1328 | Phosphorylation | DGKGIPMSLLRTIFT CCCCCCHHHHHHHHH | 20.92 | 30407730 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NRPD1_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NRPD1_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NRPD1_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CLSY1_ARATH | CHR38 | physical | 21811420 | |
| RDR2_ARATH | RDR2 | physical | 21811420 | |
| RDM4_ARATH | RDM4 | physical | 21811420 | |
| CLSY2_ARATH | CHR42 | physical | 21811420 | |
| CLSY3_ARATH | chr31 | physical | 21811420 | |
| CLSY4_ARATH | chr40 | physical | 21811420 | |
| SHH1_ARATH | AT1G15215 | physical | 21811420 | |
| NRPD1_ARATH | NRPD1A | physical | 21811420 | |
| NRPD2_ARATH | NRPD2A | physical | 21811420 | |
| NRPB3_ARATH | NRPB3 | physical | 21811420 | |
| NRPD4_ARATH | NRPD4 | physical | 21811420 | |
| RPD3B_ARATH | NRPE3B | physical | 21811420 | |
| RPB5A_ARATH | NRPB5 | physical | 21811420 | |
| RPD5B_ARATH | RPB5D | physical | 21811420 | |
| RPD6A_ARATH | NRPB6A | physical | 21811420 | |
| NRPD7_ARATH | NRPD7 | physical | 21811420 | |
| NRPE7_ARATH | NRPE7 | physical | 21811420 | |
| RPB8B_ARATH | NRPB8B | physical | 21811420 | |
| RPB9A_ARATH | NRPB9A | physical | 21811420 | |
| RPB9B_ARATH | NRPB9B | physical | 21811420 | |
| NRPBA_ARATH | NRPB10 | physical | 21811420 | |
| NRPBB_ARATH | NRPB11 | physical | 21811420 | |
| NRPBC_ARATH | NRPB12 | physical | 21811420 | |
| ROS1_ARATH | DML1 | genetic | 25420628 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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