RDR2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RDR2_ARATH
• UniProt AC: O82504
• Protein Name: RNA-dependent RNA polymerase 2
• Gene Name: RDR2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1133
• Subcellular Localization: Nucleus, nucleoplasm . Nucleus, nucleolus . In the nucleolus, localized in a ring or crescent around the inner periphery and to a distinctive nucleolar dot.
• Protein Description: RNA-dependent direct polymerase involved in the production of small interfering RNAs (siRNAs). Required for the biogenesis of endogenous siRNAs of 24 nucleotide which derive from heterochromatin and DNA repeats such as transposons or endogenous gene tandem repeats, such as repeats present in FWA gene. Involved in transcriptional gene silencing (TGS). Component of the RNA-directed DNA methylation (RdDM) silencing pathway that utilizes siRNAs to guide DNA methyltransferases to asymmetric cytosines. Involved in control of flowering time through RdDM of FWA locus. Required for reception of long-distance mRNA silencing in the shoot. Required for the formation of telomeric siRNAs and the RNA-dependent DNA methylation of asymmetric cytosines in telomeric (5'-CCCTAAA-3') repeats..
• Protein Sequence: MVSETTTNRSTVKISNVPQTIVADELLRFLELHLGEDTVFALEIPTTRDNWKPRDFARVQFTTLEVKSRAQLLSSQSKLLFKTHNLRLSEAYDDIIPRPVDPRKRLDDIVLTVGFPESDEKRFCALEKWDGVRCWILTEKRRVEFWVWESGDCYKIEVRFEDIIETLSCCVNGDASEIDAFLLKLKYGPKVFKRVTVHIATKFKSDRYRFCKEDFDFMWIRTTDFSGSKSIGTSTCFCLEVHNGSTMLDIFSGLPYYREDTLSLTYVDGKTFASAAQIVPLLNAAILGLEFPYEILFQLNALVHAQKISLFAASDMELIKILRGMSLETALVILKKLHQQSSICYDPVFFVKTQMQSVVKKMKHSPASAYKRLTEQNIMSCQRAYVTPSKIYLLGPELETANYVVKNFAEHVSDFMRVTFVEEDWSKLPANALSVNSKEGYFVKPSRTNIYNRVLSILGEGITVGPKRFEFLAFSASQLRGNSVWMFASNEKVKAEDIREWMGCFRKIRSISKCAARMGQLFSASRQTLIVRAQDVEQIPDIEVTTDGADYCFSDGIGKISLAFAKQVAQKCGLSHVPSAFQIRYGGYKGVIAVDRSSFRKLSLRDSMLKFDSNNRMLNVTRWTESMPCFLNREIICLLSTLGIEDAMFEAMQAVHLSMLGNMLEDRDAALNVLQKLSGENSKNLLVKMLLQGYAPSSEPYLSMMLRVHHESQLSELKSRCRILVPKGRILIGCMDEMGILEYGQVYVRVTLTKAELKSRDQSYFRKIDEETSVVIGKVVVTKNPCLHPGDIRVLDAIYEVHFEEKGYLDCIIFPQKGERPHPNECSGGDLDGDQFFVSWDEKIIPSEMDPPMDYAGSRPRLMDHDVTLEEIHKFFVDYMISDTLGVISTAHLVHADRDPEKARSQKCLELANLHSRAVDFAKTGAPAEMPYALKPREFPDFLERFEKPTYISESVFGKLYRAVKSSLAQRKPEAESEDTVAYDVTLEEAGFESFIETAKAHRDMYGEKLTSLMIYYGAANEEEILTGILKTKEMYLARDNRRYGDMKDRITLSVKDLHKEAMGWFEKSCEDEQQKKKLASAWYYVTYNPNHRDEKLTFLSFPWIVGDVLLDIKAENAQRQSVEEKTSGLVSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
329	Phosphorylation	LRGMSLETALVILKK HCCCCHHHHHHHHHH	30.50	28295753
694	Phosphorylation	VKMLLQGYAPSSEPY HHHHHCCCCCCCCCH	11.46	28295753
697	Phosphorylation	LLQGYAPSSEPYLSM HHCCCCCCCCCHHHH	38.88	28295753
698	Phosphorylation	LQGYAPSSEPYLSMM HCCCCCCCCCHHHHH	41.34	28295753
701	Phosphorylation	YAPSSEPYLSMMLRV CCCCCCCHHHHHHHH	13.83	28295753
703	Phosphorylation	PSSEPYLSMMLRVHH CCCCCHHHHHHHHCC	9.05	28295753
950	Phosphorylation	LERFEKPTYISESVF HHHCCCCCEECHHHH	44.55	23172892
951	Phosphorylation	ERFEKPTYISESVFG HHCCCCCEECHHHHH	15.81	19880383
953	Phosphorylation	FEKPTYISESVFGKL CCCCCEECHHHHHHH	17.26	23172892
955	Phosphorylation	KPTYISESVFGKLYR CCCEECHHHHHHHHH	18.89	23172892

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RDR2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RDR2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RDR2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SHH1_ARATH	AT1G15215	physical	23637343
RDR2_ARATH	RDR2	physical	23637343

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.