NRPB3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRPB3_ARATH
• UniProt AC: Q39211
• Protein Name: DNA-directed RNA polymerases II, IV and V subunit 3
• Gene Name: NRPB3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 319
• Subcellular Localization: Nucleus.
• Protein Description: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. NRPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft. Component of RNA polymerases IV and V which mediate short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of endogenous repeated sequences, including transposable elements..
• Protein Sequence: MDGATYQRFPKIKIRELKDDYAKFELRETDVSMANALRRVMISEVPTVAIDLVEIEVNSSVLNDEFIAHRLGLIPLTSERAMSMRFSRDCDACDGDGQCEFCSVEFRLSSKCVTDQTLDVTSRDLYSADPTVTPVDFTIDSSVSDSSEHKGIIIVKLRRGQELKLRAIARKGIGKDHAKWSPAATVTFMYEPDIIINEDMMDTLSDEEKIDLIESSPTKVFGMDPVTRQVVVVDPEAYTYDEEVIKKAEAMGKPGLIEISPKDDSFIFTVESTGAVKASQLVLNAIDLLKQKLDAVRLSDDTVEADDQFGELGAHMRGG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDGATYQR -------CCCCCCCC		22223895
216	Phosphorylation	KIDLIESSPTKVFGM HHHHHHCCCCEECCC		19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NRPB3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRPB3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRPB3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CPL4_ARATH	CPL4	physical	25041272
NFYB1_ARATH	NF-YB1	physical	25490919
NFYB2_ARATH	NF-YB2	physical	25490919
NFYB3_ARATH	NF-YB3	physical	25490919
NFYB6_ARATH	NF-YB6	physical	25490919
NFYB7_ARATH	NF-YB7	physical	25490919
NRPB4_ARATH	NRPB4	physical	25490919
RPD3B_ARATH	NRPE3B	physical	8617787
NRPBB_ARATH	NRPB11	physical	8617787

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.